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Fadogia agrestis extract

Also known as: Fadogia, Fadogia agrestis (Schweinf. Ex Hiern), Fadogia agrestis

Overview

Fadogia agrestis is a plant used in traditional African medicine, known for its analgesic, anti-inflammatory, and purported aphrodisiac properties. As a supplement, it is primarily marketed to enhance sexual performance and increase testosterone levels. The plant contains alkaloids, saponins, and trace amounts of anthraquinones and flavonoids. Research on Fadogia agrestis is limited, with most studies conducted on rats, highlighting the need for human trials to validate its effects and safety. The available evidence suggests potential benefits in boosting testosterone and improving sexual behavior, but these findings have not been consistently replicated or confirmed in human populations. Therefore, caution is advised when considering its use as a supplement.

Benefits

Animal studies, primarily in rats, suggest that Fadogia agrestis extract may increase serum testosterone levels in a dose-dependent manner. These studies also report a significant increase in sexual behavior parameters, such as mount frequency and intromission frequency. Additionally, there is some evidence suggesting it may help manage erectile dysfunction by enhancing nitric oxide and cGMP pathways. However, it is crucial to note that these benefits have only been demonstrated in male rats, and there is a lack of human trials to confirm these effects. The clinical significance and applicability of these findings to humans remain uncertain.

How it works

Fadogia agrestis is thought to stimulate testosterone production by increasing luteinizing hormone levels. It may also enhance the NO/cGMP pathway, which is crucial for erectile function. The exact mechanisms of action and molecular targets are not fully understood, and further research is needed to elucidate the specific biological pathways involved. The absorption and bioavailability of Fadogia agrestis in humans are also not well-studied, making it difficult to determine optimal dosing and timing for supplementation.

Side effects

Due to the limited number of human studies, the side effects of Fadogia agrestis are not well-established. Animal studies have indicated potential adverse effects on testicular function at higher doses. Common, uncommon, and rare side effects in humans are currently unknown. Drug interactions and contraindications are also not well-documented. Caution is advised, especially for individuals with pre-existing health conditions or those taking other medications. Further research is needed to fully understand the safety profile of Fadogia agrestis and to identify any potential risks associated with its use.

Dosage

The minimum effective dose of Fadogia agrestis, based on rat studies, is approximately 18 mg/kg body weight. However, optimal dosage ranges for humans have not been established. The maximum safe dose is also unknown. There are no established guidelines for timing considerations or form-specific recommendations. Due to the lack of human data, it is difficult to provide specific dosing recommendations. It is essential to consult with a healthcare professional before using Fadogia agrestis to determine a safe and appropriate dosage.

FAQs

Is Fadogia agrestis a proven testosterone booster?

The evidence supporting Fadogia agrestis as a testosterone booster is primarily based on animal studies. Human trials are lacking, so its effectiveness in humans is uncertain.

Are there any known side effects of taking Fadogia agrestis?

Due to the lack of human studies, the side effects are not well-established. Animal studies suggest potential adverse effects on testicular function at high doses.

How should I take Fadogia agrestis?

There are no established guidelines for timing or administration due to the lack of human data. Consult with a healthcare professional for personalized advice.

What results can I expect from taking Fadogia agrestis?

Expected results are uncertain due to the limited research in humans. Animal studies show potential benefits, but these have not been confirmed in human trials.

Is Fadogia agrestis safe for everyone?

Caution is advised due to the lack of human data. Individuals with pre-existing health conditions or those taking other medications should consult a healthcare professional before use.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/18023305/ – This animal study investigated the effects of Fadogia agrestis on testicular function in rats over 28 days. The key finding was that higher doses of the extract led to adverse effects on the rats' testicular function, indicating potential risks associated with high dosages. This study provides insight into potential risks but lacks human relevance.
https://pubmed.ncbi.nlm.nih.gov/35969364/ – This animal study explored the impact of Fadogia agrestis on erectile dysfunction in male Wistar rats. The study found that the extract improved erectile function by enhancing nitric oxide and cGMP pathways. While these results suggest potential benefits, they require validation through human trials to confirm their applicability.
https://pubmed.ncbi.nlm.nih.gov/16281088/ – This animal study assessed the aphrodisiac potential of Fadogia agrestis in male albino rats over a 5-day period. The study reported increased testosterone levels and improved sexual behavior in the rats. Although the results demonstrate potential aphrodisiac effects, human confirmation is necessary to validate these findings.
https://pubmed.ncbi.nlm.nih.gov/30170324/ – This study investigated the effects of Fadogia agrestis on reproductive hormones and testicular function in male rats. The findings indicated that while the extract may increase testosterone levels, it also has the potential to cause testicular damage at higher doses. This highlights the importance of further research to determine safe and effective dosages for human use.
https://advancedmolecularlabs.com/blogs/news/testosterone-booster-research-update-fodagia-agrestis-is-it-the-real-deal – This blog post summarizes the current research on Fadogia agrestis as a testosterone booster. It highlights that most studies are animal-based and that human trials are needed to confirm its effectiveness and safety. The post emphasizes the importance of caution when considering Fadogia agrestis as a supplement due to the limited evidence.