Evodia Rutaecarpa Extract
Also known as: Wu-Zhu-Yu, Evodia, Evodia rutaecarpa
Overview
Evodia rutaecarpa is a plant utilized in traditional Chinese medicine primarily for its fruit, which contains several bioactive compounds such as evodiamine, rutaecarpine, and dehydroevodiamine. This extract is commonly employed in managing various digestive system conditions, including diarrhea, dysentery, nausea, vomiting, and abdominal pain. It has also been recognized for its potential anti-inflammatory and anti-cancer properties. Characterized by a high concentration of indole quinazoline alkaloids, Evodia is increasingly researched, although more rigorous human clinical trials are essential to validate its efficacy and safety profile. Current evidence, primarily from systematic reviews, meta-analyses, and animal studies, suggests moderate to high research quality supporting its therapeutic effects.
Benefits
Evodiamine (EVO) has demonstrated significant benefits in treating digestive diseases such as colorectal cancer, gastric ulcers, and ulcerative colitis, showing anti-proliferative effects on cancer cells in animal studies. Additionally, a biomimetic mixture derived from Evodia has been proven to effectively inhibit inflammation in human skin, demonstrating superiority over bisabolol from chamomile. The extract exhibits anti-inflammatory activity by inhibiting the release of inflammatory mediators and also shows vasodilatory and anti-thrombotic effects, suggesting its potential applications in vascular health. Although the observed benefits mainly arise from non-human models, the notable anti-inflammatory effects in human studies warrant further investigation in clinical settings to establish its practical applications.
How it works
Evodiamine exerts its therapeutic effects through interaction with a variety of biological pathways, including TGF-β, PI3K-AKT, Wnt, and NF-κB, among others. The extract influences gastrointestinal function and inflammation by modulating signaling pathways that are crucial for cellular responses. Evodia also enhances calcium signaling, which may aid in regulating gastrointestinal disorders. These interactions suggest a multifaceted mechanism by which Evodia rutaecarpa impacts the digestive, immune, and vascular systems in the body.
Side effects
The overall safety profile of Evodia rutaecarpa extract remains unclear, as comprehensive human clinical studies are lacking. Commonly reported side effects in animal studies have not been significantly documented. However, caution is advised for individuals with liver or kidney conditions due to potential interactions with medications, particularly those metabolized by cytochrome P450 enzymes. Although rare or uncommon side effects (<5%) have not been well-documented, users should be aware of the potential risks. Pregnant or breastfeeding women should approach Evodia use cautiously due to insufficient safety data in these populations. Safety assessments underline the need for carefully monitored studies to fully elucidate any adverse effects associated with routine consumption.
Dosage
No established minimum effective dose exists for Evodia rutaecarpa extract. Optimal dosage ranges vary widely across studies, with results differing based on concentrations and formulations used. As current evidence does not define clear dosage guidelines, more human clinical trials are essential to ascertain safe and effective dosage recommendations. The extract is available in various forms, including granules, tablets, and liquid formulations, with modern pharmaceutical techniques enhancing stability and bioavailability. Users are encouraged to consider individual health conditions and consult healthcare providers for tailored advice regarding timing, dosage, and absorption factors.
FAQs
Is Evodia rutaecarpa safe to use?
The safety profile of Evodia rutaecarpa is not fully established, demanding further research to confirm its safety across diverse populations.
What is the best time to take Evodia extract?
Timing for Evodia extract administration relies on the specific condition being treated and the formulation used.
What benefits can I expect from Evodia rutaecarpa?
Expected benefits include anti-inflammatory, anti-cancer, and digestive support effects, pending confirmation from clinical trials.
Are there common misconceptions about Evodia?
A common misconception is that Evodia rutaecarpa is entirely safe and effective; further research is essential for validating these claims.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/39018943/ – This systematic review reveals that evodiamine has promising effects on digestive diseases, indicating its interaction with multiple biological pathways for anti-cancer and anti-inflammatory actions. Research is primarily based on animal models.
- https://pubmed.ncbi.nlm.nih.gov/16423507/ – This study assessed the anti-inflammatory activity of Evodia in human skin, showing significant efficacy in reducing erythema, indicating its potential for topical applications.
- https://www.rxlist.com/supplements/evodia.htm – A review article summarizing various therapeutic effects of Evodia rutaecarpa, noting interaction with biological pathways and the necessity for more detailed studies on its safety and efficacy.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1397247/full – This analysis emphasizes the diverse therapeutic effects of Evodia rutaecarpa, highlighting its role in gastrointestinal health and urges further research in human clinical contexts.
- https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010284/appendices – The review presents pooled data from various studies on Evodia, focusing on its potential benefits and articulating the imperative for detailed human investigations.
Supplements Containing Evodia Rutaecarpa Extract
ThermoGain
MuscleTech
Intensify Xtreme
FitLife Brands
Pro Thermogenic Diablo Electric Lime
ANS Performance
Pro Thermogenic Diablo Pineapple Passionfruit
ANS Performance
Jetfuel Superburn
GAT
Shock'd Lemon Ice
SirenLabs
Shock'd Grape
SirenLabs
Shock'd Strawberry
SirenLabs
Shock'd Strawberry
SirenLabs
Pyroxamine
Myokem
Intensify Xtreme
NDS