Evnol Suprabio
Also known as: Tocotrienols, Tocopherols, Vitamin E, Bioenhanced tocotrienols, EVNol SupraBio
Overview
EVNol SupraBio is a patented bioenhanced full spectrum tocotrienols/tocopherol complex derived from sustainably produced virgin red palm oil, known for its potent antioxidant properties. As a vital source of vitamin E, it exhibits hepatoprotective effects primarily in managing conditions such as non-alcoholic fatty liver disease (NAFLD) and end-stage liver disease (ESLD). The SupraBio delivery system significantly enhances the absorption of tocotrienols into human plasma, facilitating its therapeutic effects. Research on EVNol SupraBio is relatively mature with several clinical studies supporting its efficacy; however, further independent evaluations are needed to validate its claims.
Benefits
EVNol SupraBio has demonstrated several evidence-backed benefits, particularly in patients with NAFLD and ESLD. A clinical study showed that 66.7% of NAFLD patients experienced significant improvements, with 50% achieving complete remission after 12 months of supplementation (p < 0.05). Additionally, supplementation in ESLD patients (200mg, twice daily) resulted in nearly 50% of patients exhibiting reduced MELD scores, indicating liver protective effects. The tocotrienols also have potential anti-inflammatory effects and can help lower triglyceride accumulation. While benefits have been documented, particularly in liver health, more research is warranted to explore effects on other conditions.
How it works
The liver benefits from EVNol SupraBio primarily through the antioxidant properties of tocotrienols, which reduce lipid peroxidation and inflammation. By inhibiting NF-κB expression and regulating key enzymes involved in fatty acid metabolism, such as fatty acid synthase and carnitine palmitoyltransferase, tocotrienols help mitigate liver damage. This formulation ensures enhanced bioavailability, achieving up to 300% more absorption in human plasma compared to standard forms.
Side effects
EVNol SupraBio is generally regarded as safe, with no significant adverse effects reported in clinical trials. While common and uncommon side effects were not observed, caution is advised for specific populations, particularly those with bleeding disorders, as high doses of vitamin E may impart anticoagulant effects. Additionally, pregnant or breastfeeding women should consult healthcare providers before use due to limited safety data. Long-term effects remain largely unstudied; thus, ongoing monitoring is advisable. Overall, more comprehensive assessments of drug interactions and rare side effects are warranted.
Dosage
The recommended dosage for managing NAFLD is 50mg of d-mixed-tocotrienol (EVNol SupraBio) taken twice daily. For patients with ESLD, a dosage of 200mg twice daily has been utilized successfully in clinical studies. While optimal dosage can vary based on individual needs, it's important to note that long-term supplementation appears necessary to achieve sustained benefits. The SupraBio system significantly enhances absorption, suggesting that adherence to the recommended form is essential. There are no defined maximum safe doses, but individuals should be cautious about potential bleeding risks associated with high vitamin E intake.
FAQs
How long should I take EVNol SupraBio?
Long-term supplementation is suggested for sustained benefits, particularly for liver health.
Are there any side effects?
No significant side effects have been reported in the studies, although caution is advised in specific populations.
Is EVNol SupraBio safe for everyone?
Generally considered safe, but it's advisable to consult with a healthcare provider for those with bleeding disorders.
When should I take EVNol SupraBio?
It is recommended to take it twice daily as part of a long-term regimen.
What can I expect from taking EVNol SupraBio?
Users can expect significant improvements in liver health, especially for NAFLD and ESLD patients.
Research Sources
- https://nutraceuticalbusinessreview.com/hepatoprotective-effects-of-tocopherols-and-tocotrienols-in-fatty-liver-disease-114312 – This study reviews the hepatoprotective effects of tocopherols and tocotrienols, highlighting significant clinical findings related to fatty liver disease management using tocotrienol supplementation.
- https://magistralbr.caldic.com/storage/product-files/15081801.pdf – This document provides a summary of various studies on tocotrienols, including their bioavailability and health benefits, particularly in liver health.
- https://www.hpcimedia.com/images/PDF/EVNol_Excelvite.pdf – The report details the development and advantages of the EVNol SupraBio delivery system, demonstrating its enhanced absorption and efficacy in human subjects.
