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Eurycomanone

Also known as: Eurycomanone, Tongkat Ali extract, Eurycoma longifolia extract

Overview

Eurycomanone is a quassinoid compound found primarily in the root extract of *Eurycoma longifolia*, a plant commonly known as Tongkat Ali. This bioactive compound is often associated with supplements aimed at enhancing male fertility and testosterone levels. Traditionally, *Eurycoma longifolia* has been used to improve male libido and fertility. Eurycomanone is believed to play a key role in testosterone steroidogenesis and spermatogenesis. While research suggests potential benefits, further rigorous clinical trials are needed to fully understand its efficacy and safety in humans. It is available in various forms, including capsules and powders, derived from *Eurycoma longifolia* root extracts.

Benefits

Eurycomanone, primarily through *Eurycoma longifolia* extracts, has shown potential in increasing testosterone production. Animal studies suggest it inhibits aromatase, reducing the conversion of testosterone to estrogen. Human studies indicate that *Eurycoma longifolia* supplementation is associated with increased testosterone levels. One study reported a 15% increase in testosterone and a 34% increase in free testosterone in young males after two weeks of supplementation. It may also enhance fertility by increasing spermatogenesis, although more research is needed to confirm this effect. These benefits are primarily observed in males, especially those with hypogonadism or low testosterone levels. The evidence is based on limited human trials, so more rigorous clinical trials are needed.

How it works

Eurycomanone is believed to enhance testosterone production through its action on the hypothalamic-pituitary-gonadal axis. It inhibits aromatase, an enzyme that converts testosterone to estrogen, thereby increasing testosterone levels. This interaction with the endocrine system specifically affects testosterone and estrogen balance. Eurycomanone targets steroidogenesis enzymes, particularly aromatase, to modulate hormone production. While the exact absorption and bioavailability mechanisms are not fully understood, it is effective when ingested as part of *Eurycoma longifolia* extracts.

Side effects

While generally considered safe, comprehensive data on the long-term use and potential interactions of eurycomanone are still needed. Common side effects are not well-documented, but rare cases of gastrointestinal issues have been associated with *Eurycoma longifolia* extracts. Uncommon side effects may include potential interactions with certain medications, such as beta-blockers. Rare side effects, observed in acute toxicity studies in mice, indicate toxicity with high doses of specific fractions of *Eurycoma longifolia*. Drug interactions may occur with medications like propranolol, affecting bioavailability. Caution is advised for individuals with pre-existing medical conditions or those taking specific medications. Pregnant or breastfeeding women should avoid it due to a lack of safety data.

Dosage

While a specific minimum effective dose for eurycomanone is not established, *Eurycoma longifolia* extracts are commonly used at doses around 600 mg per day. Typical dosage ranges for *Eurycoma longifolia* extracts are between 200-600 mg daily. The maximum safe dose is not well-defined, but higher doses may increase the risk of adverse effects. There are no specific timing recommendations for administration. It is often consumed as a capsule or powder supplement. Bioavailability may vary based on the form and preparation of the extract. No specific cofactors are required for its effectiveness.

FAQs

Should I consult a healthcare provider before taking Eurycomanone?

Yes, it is advisable to consult a healthcare provider before starting supplementation, especially if you are taking other medications or have pre-existing health conditions.

Is Eurycomanone safe to use?

While generally considered safe, more research is needed to fully understand potential side effects and interactions. Follow recommended dosages and be aware of any adverse reactions.

What results can I expect from taking Eurycomanone?

Potential benefits include an increase in testosterone levels and improved fertility, but individual results may vary. It is not a guaranteed treatment for low testosterone or fertility issues.

How should I take Eurycomanone?

No specific timing is recommended, but consistency is key. Follow the dosage instructions on the product label or as advised by your healthcare provider.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/36013514/ – This systematic review and meta-analysis included nine studies and found a significant increase in total testosterone levels in men receiving *Eurycoma longifolia* supplementation. The meta-analysis focused on five RCTs, supporting the potential use of *Eurycoma longifolia* for enhancing testosterone production, but the authors noted that more research is needed for clinical practice.
https://pubmed.ncbi.nlm.nih.gov/23419023/ – This study investigated the effect of *Eurycoma longifolia* supplementation on stress hormones and mood state in moderate stressed subjects. The results indicated that *Eurycoma longifolia* can modulate stress hormone levels and improve certain mood state parameters. This suggests a potential role for *Eurycoma longifolia* in managing stress and improving overall well-being.
https://onlinelibrary.wiley.com/doi/10.1111/and.14001 – This randomized controlled trial examined the effects of *Eurycoma longifolia* supplementation in 32 young males over two weeks. The study found significant increases in both testosterone and free testosterone levels. However, the authors noted the limitations of the small sample size and short duration, suggesting the need for further research with larger cohorts and longer intervention periods.
https://pubmed.ncbi.nlm.nih.gov/23810842/ – This in vitro and animal study investigated the effects of eurycomanone on rat testicular cells. The study found that eurycomanone increases testosterone production by inhibiting aromatase. While the animal model limits direct applicability to humans, the study supports potential mechanisms of action for eurycomanone in testosterone production.
https://magistralbr.caldic.com/storage/product-files/445511096.pdf – This document provides information on the acute toxicity of *Eurycoma longifolia* extracts in mice. The study showed that high doses of certain fractions of *Eurycoma longifolia* can be toxic. This highlights the importance of adhering to recommended dosages and being aware of potential adverse effects at high concentrations.