Etas
Also known as: Asparagus stem extract, ETAS, ETAS (Asparagus officinalis extract)
Overview
ETAS is a standardized extract from the stem of *Asparagus officinalis*, known for its culinary and medicinal applications. Rich in bioactive compounds, ETAS is primarily recognized for its potential cognitive benefits, making it a focus in dietary supplements and functional food ingredients. Emerging research indicates that ETAS may support cognitive health, particularly in populations with mild cognitive impairment and normal aging, demonstrating improvements in cognitive function metrics like MMSE and FAB scores. Although currently limited, existing studies show promise, warranting further investigation through larger-scale trials to substantiate its efficacy and safety in mainstream usage.
Benefits
ETAS supplementation has been associated with significant improvements in cognitive function metrics, particularly in the Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB). Studies indicate reductions in symptoms of anxiety and depression, as measured by the Hospital Anxiety and Depression Scale (HADS). Beneficial effects are particularly noted in individuals with mild cognitive impairment (MCI) and normal aging. Improvements observed in cognitive performance over a 12-month supplementation period suggest a potential clinical relevance, although most evidence stems from small-scale studies necessitating more robust research designs.
How it works
While the exact mechanisms of ETAS remain unclear, it is believed to promote cognitive health through neuroprotective effects and the modulation of stress-related proteins like heat-shock protein 70 (HSP70). ETAS may also engage with the nervous and immune systems, assisting in maintaining normal CD4/CD8 ratios, which could have implications for cognitive stability.
Side effects
ETAS is generally regarded as safe, with no significant adverse effects documented in available studies. While common side effects are absent, some subjects have reported transient discomforts such as nausea, satiety, and abdominal pain, which are not definitively linked to ETAS supplementation. There are currently no well-documented drug interactions or contraindications; however, safety guidance for specific populations like pregnant women, children, or individuals with severe health conditions remains undefined. As the research base expands, clarity on potential long-term effects and interactions may become available.
Dosage
The minimum recommended dose of ETAS for cognitive support is 1,000 mg per day, although optimal dosages have not been extensively established. The studies primarily utilized an encapsulated form of the extract for supplementation, taken daily for consistency. There is currently no determined maximum safe dose or upper limit known, underscoring the need for further research to establish comprehensive dosing guidelines.
FAQs
How should ETAS be taken?
ETAS is typically taken as a dietary supplement, with daily intake recommended to support cognitive health.
Is ETAS safe?
ETAS is generally considered safe based on available research, but long-term effects and interactions with medications have not been extensively studied.
What results can I expect from ETAS?
Potential benefits include cognitive enhancements and reduced symptoms of anxiety and depression, particularly in older adults or those with mild cognitive impairment.
Can ETAS cure cognitive decline?
ETAS is not a cure for cognitive decline but may help in slowing its progression and improving cognitive function.
Are there any known side effects?
Common side effects have not been reported, though transient nausea and abdominal discomfort have been noted occasionally.
Research Sources
- https://jppres.com/jppres/pdf/vol12/jppres23.1742_12.1.154.pdf – This pilot randomized controlled trial examined the effects of ETAS on cognitive performance. Over 12 months and involving thirty subjects, significant improvements in MMSE, FAB, and HADS scores were observed, though the study's small sample limits generalizability.
- https://pubmed.ncbi.nlm.nih.gov/15051593/ – This publication provides overview insights into various studies surrounding cognitive enhancement supplements. While not directly focused on ETAS, it contextualizes the extract within the broader category of dietary supplements aimed at improving cognitive function.
- https://pubmed.ncbi.nlm.nih.gov/29508691/ – A related study discusses the mechanisms through which dietary supplements can impact cognitive health, offering insights that may complement the understanding of ETAS's action within the nervous system.
- https://www.edresearch.edu.au/sites/default/files/2023-05/aero-supporting-students-significantly-behind-literacy-numeracy.pdf – This document outlines enriching educational practices and the importance of cognitive support, indirectly referencing the significance of cognitive supplementation, like ETAS, in supporting the learning process.
- https://academic.oup.com/pmj/article/98/1158/285/6958842?login=false – This article reviews various intervention strategies for cognitive decline, placing extracts like ETAS within the context of effective dietary solutions that warrant further multi-center RCT evaluation.
