Get Your Personalized Supplement StackSupplement Stack Quiz

Eleuthero Root Powder

Also known as: Eleutherococcus senticosus, Acanthopanax senticosus, Siberian ginseng

Overview

Eleuthero (*Eleutherococcus senticosus*), also known as Siberian ginseng, is an adaptogenic herb native to regions of Japan, China, Russia, and Korea. Despite its common name, it is not related to true ginseng. It has been traditionally used to enhance the body's resilience to various stressors, including physical, environmental, and emotional challenges. The plant contains active compounds called eleutherosides, which are believed to contribute to its adaptogenic properties. Eleuthero is available in various forms, including capsules, tablets, liquid extracts, and powders. It is often used to improve energy levels, cognitive function, athletic performance, and immune system function. While some studies suggest potential benefits, more robust human research is needed to confirm these effects.

Benefits

Eleuthero has shown potential benefits in several areas, although the evidence is often limited and requires further validation through rigorous human studies. A specific eleuthero extract (Elagen) has demonstrated effectiveness in reducing the frequency, severity, and duration of genital herpes outbreaks. Studies have also indicated that eleuthero may help lower blood sugar levels in individuals with type 2 diabetes. Additionally, some research suggests that eleuthero can enhance immune response and possess anti-inflammatory properties. Animal studies have shown improvements in cognitive function and memory, but these findings need to be replicated in human trials. While some evidence suggests that eleuthero may improve physical performance, more human trials are necessary to confirm this benefit. Overall, the clinical significance of eleuthero's benefits remains uncertain due to the limited number of high-quality human studies.

How it works

Eleuthero is believed to exert its adaptogenic effects through multiple biological pathways. It modulates the immune system, exhibits anti-inflammatory properties, and provides antioxidant activity. The active compounds, such as eleutherosides B and E, interact with various molecular targets, influencing the brain, immune system, and hormone regulation. These interactions contribute to the plant's ability to enhance the body's resistance to stress. However, the precise mechanisms of action are not fully understood, and further research is needed to elucidate the specific molecular targets and pathways involved. Limited information is available regarding the absorption and bioavailability of eleuthero compounds in humans.

Side effects

Eleuthero is generally considered safe for short-term use (up to 3 months) at recommended doses. Common side effects include diarrhea, stomach upset, and headache. Less common side effects may include increased blood pressure, increased bleeding risk, and elevated blood sugar levels. Rare side effects, such as breast tenderness, palpitations, tachycardia, and uterine bleeding at higher-than-normal doses, have also been reported. Eleuthero may interact with diabetes medications, anticoagulant/antiplatelet drugs, immunosuppressants, and medications metabolized by CYP2D6 and CYP3A4. It should be used with caution in patients with heart conditions and avoided during pregnancy and breastfeeding due to a lack of safety data. Children and teenagers should use eleuthero under supervision, and it is possibly safe for teenagers (ages 12-17) for up to 6 weeks. Long-term safety data is lacking, and caution is advised.

Dosage

The minimum effective dose of eleuthero is not well-established, but doses of 400 mg per day have been used in some studies. Typical dosage ranges from 400 mg to 1200 mg per day, often divided into multiple doses. There is no established maximum safe dose, but exceeding recommended doses may increase the risk of side effects. Dosing timing can vary depending on the condition being treated. Eleuthero is often used as an extract containing specific percentages of eleutherosides. Limited information is available on absorption factors. No specific cofactors are identified as necessary for its effectiveness. Consult with a healthcare provider for personalized dosage recommendations.

FAQs

Is eleuthero safe?

Eleuthero is generally safe for short-term use, but long-term safety data is lacking. Use with caution if you have heart conditions or are taking medications. Avoid during pregnancy and breastfeeding.

When should I take eleuthero?

Dosing timing varies by condition. For upper respiratory infections, it is recommended to take it within 72 hours of onset. Consult a healthcare provider for specific guidance.

What are the expected benefits of eleuthero?

Potential benefits include improved immune function, reduced fatigue, and enhanced cognitive function. However, these are based on limited human evidence and may not be experienced by everyone.

Is eleuthero the same as ginseng?

No, eleuthero is often confused with true ginseng, but it is a distinct plant with different constituents and effects. It is also known as Siberian ginseng, but it is not related to true ginseng.

Research Sources

https://www.medicalnewstoday.com/articles/319084 – This article provides a general overview of eleuthero, including its potential benefits, uses, and side effects. It highlights its traditional use as an adaptogen and its potential to improve energy, cognitive function, and immune response. The article also notes the need for more research to confirm these effects.
https://www.ncbi.nlm.nih.gov/sites/books/NBK501806/ – This resource from the National Center for Biotechnology Information provides detailed information on eleuthero, including its chemical constituents, pharmacological effects, and safety profile. It emphasizes the importance of eleutherosides in its adaptogenic properties and discusses its potential interactions with various body systems. The resource also highlights the need for more robust human studies to fully understand its benefits and risks.
https://pubmed.ncbi.nlm.nih.gov/30000865/ – This study investigates the effects of eleuthero on immune function and inflammation. It provides evidence for its anti-inflammatory effects on macrophages and its ability to improve immune response. The findings suggest that eleuthero may have potential as an immunomodulatory agent, but further research is needed to confirm these effects in humans.
https://www.webmd.com/vitamins/ai/ingredientmono-985/eleuthero – This WebMD article offers a consumer-friendly overview of eleuthero, including its uses, dosage, side effects, and interactions. It provides practical information for individuals considering using eleuthero as a supplement. The article also emphasizes the importance of consulting with a healthcare provider before using eleuthero, especially if you have any underlying health conditions or are taking medications.
https://www.va.gov/WHOLEHEALTHLIBRARY/docs/Adaptogens.pdf – This document from the Department of Veterans Affairs provides information on adaptogens, including eleuthero. It discusses their role in helping the body adapt to stress and their potential benefits for various health conditions. The document also highlights the importance of using adaptogens under the guidance of a healthcare provider.