NEM Eggshell Membrane, Elastin, Glycosaminoglycans
Also known as: NEM, eggshell membrane, ESM (eggshell membrane), egg membrane extract, Elastin, Glycosaminoglycans, GAGs, NEM (Natural Eggshell Membrane)
Overview
NEM (Natural Eggshell Membrane) is a supplement derived from the inner lining of eggshells, composed primarily of fibrous proteins like collagen type I and elastin, glycosaminoglycans (GAGs) such as dermatan sulfate, chondroitin sulfate, and hyaluronic acid, and hexosamines like glucosamine. It is primarily used to alleviate joint pain and stiffness, particularly in individuals with osteoarthritis (OA), and is also being investigated for its potential benefits in bone health. NEM contains bioactive components that support the integrity of joint and connective tissues. Research suggests that NEM supplementation can lead to significant reductions in pain and stiffness, with a rapid onset of benefits typically observed within 10 to 30 days. While the quality of evidence is good for joint pain and stiffness in OA, further research is needed to fully establish its efficacy for bone health. NEM is orally bioavailable, allowing its components to be absorbed and distributed to connective tissues, making it a convenient option for those seeking joint support.
Benefits
NEM supplementation has demonstrated significant benefits in reducing pain and stiffness associated with osteoarthritis (OA). Studies show that a daily dose of 500 mg of NEM can reduce pain by approximately 40.6% within 10 days and 66.4% within 30 days (p < 0.001). Similarly, stiffness can be reduced by 22.2% at 10 days and 59.7% at 30 days (p < 0.001). A network meta-analysis ranked NEM highest for reducing stiffness, indicating its superior efficacy compared to other supplements. Furthermore, NEM supplementation has been associated with a reduction in analgesic consumption, suggesting it can help manage pain without relying solely on medication. Preliminary evidence also suggests potential benefits for maintaining bone density, although more research is needed to confirm these findings. These benefits are primarily observed in adults with knee OA, with moderate to large effect sizes and clinically meaningful reductions in pain and stiffness.
How it works
NEM's mechanism of action involves both immunomodulation and tissue support. It downregulates pro-inflammatory cytokines such as IL-1β and TNF-α, which reduces inflammation in the joints. Additionally, NEM provides anabolic elements like collagen, elastin, and glycosaminoglycans (GAGs) that are essential for maintaining the integrity of joint and connective tissues. These components are absorbed and distributed to connective tissues, supporting their structure and function. By targeting both inflammation and tissue repair, NEM helps to alleviate pain and stiffness while promoting overall joint health. The supplement primarily affects the musculoskeletal and immune systems, with known molecular targets including cytokines and extracellular matrix components.
Side effects
NEM is generally considered very safe, with no serious adverse events reported in clinical trials. The most commonly reported side effects are mild and transient gastrointestinal symptoms, which occur in rare cases (1-5%). These may include stomach upset or mild discomfort. There are no known significant drug interactions associated with NEM supplementation. Contraindications are not well-established, but caution is advised for individuals with egg allergies due to the eggshell origin of the supplement. While NEM is considered safe for adults, there is insufficient data to establish its safety for children, pregnant women, or lactating women. Therefore, it is recommended that these populations avoid NEM supplementation until more data are available. Overall, NEM has a favorable safety profile, but individuals should be aware of the potential for mild GI side effects and exercise caution if they have egg allergies.
Dosage
The minimum effective dose of NEM is 500 mg per day, which is also the optimal dosage range. Clinical trials have shown that 500 mg taken once daily is well-tolerated and effective for reducing joint pain and stiffness. While the maximum safe dose has not been definitively established, studies have found that up to 500 mg/day is safe. NEM can be taken at any time of day, with or without food. It is available in oral capsules or powder form, and no specific cofactors are required for absorption. Standard oral administration is sufficient for NEM to be absorbed and utilized by the body. There are no identified required cofactors that enhance its effectiveness. It is important to adhere to the recommended dosage and consult with a healthcare professional if you have any concerns.
FAQs
Is NEM safe for long-term use?
Yes, NEM is considered safe for long-term use, with no serious adverse events reported in clinical trials. However, monitoring for any potential side effects is always recommended.
How quickly can I expect to see results with NEM?
Many users report a reduction in joint pain and stiffness within 10–30 days of starting NEM supplementation. Consistent daily use is recommended for optimal results.
Can NEM cure osteoarthritis?
No, NEM is not a cure for osteoarthritis. It provides symptomatic relief by reducing pain and stiffness and may potentially slow disease progression, but it does not reverse the underlying condition.
Are there any side effects associated with NEM?
NEM is generally well-tolerated. Mild gastrointestinal symptoms are possible but rare. Individuals with egg allergies should exercise caution due to the eggshell origin of the supplement.
How should I take NEM?
NEM is typically taken once daily, with or without food. Follow the dosage instructions on the product label or as directed by your healthcare provider. Consistency is key for best results.
Research Sources
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1556133/full – This network meta-analysis evaluated the efficacy of various dietary supplements for knee osteoarthritis. The study included multiple RCTs and found that NEM ranked highest for reducing stiffness, with significant pain reduction also observed. The robust methodology supports the findings, although heterogeneity among included studies and small sample sizes in some trials were noted as limitations.
- https://www.iomcworld.org/open-access/nem-brand-eggshell-membrane-in-the-treatment-of-pain-and-stiffnessassociated-with-knee-osteoarthritis-an-open-label-clin.pdf – This open-label clinical study investigated the effects of NEM supplementation on pain and stiffness in individuals with knee osteoarthritis. The study found that 500 mg of NEM per day reduced pain and stiffness significantly over 30 days, with no reported adverse events. While the open-label design and small sample size are limitations, the results are consistent with other RCTs, suggesting NEM's potential for managing OA symptoms.
- https://pubmed.ncbi.nlm.nih.gov/38872992/ – This article discusses the potential benefits of eggshell membrane for bone health. The systematic review included preclinical and clinical studies, revealing preliminary evidence for bone health benefits. However, the authors noted that more clinical data is needed to confirm these findings, indicating that while promising, the evidence is not yet conclusive.
- https://www.scirp.org/journal/paperinformation?paperid=63996 – This open-label, single-center RCT examined the effects of NEM on knee osteoarthritis. The study found that 500 mg of NEM per day reduced pain by 40.6% at 10 days and 66.4% at 30 days, with stiffness also significantly reduced. The absence of adverse events further supports NEM's safety profile, although the open-label design and small sample size limit the strength of the conclusions.