Echinamide
Also known as: Echinacea, Coneflower
Overview
Echinacea is a popular herbal supplement derived from the Echinacea genus, primarily *Echinacea purpurea*, *Echinacea angustifolia*, and *Echinacea pallida*. Native to North America, it's widely used to prevent and treat upper respiratory tract infections (URTIs), such as the common cold. Echinacea preparations vary, including extracts, pressed juices, and dried powders. Research on Echinacea is extensive, with studies examining its efficacy in preventing URTIs. While some studies show significant benefits, others report mixed results. Systematic reviews and meta-analyses provide the most robust insights, suggesting a potential clinical benefit in reducing the incidence and duration of URTIs.
Benefits
Echinacea is primarily known for its potential to reduce the incidence and duration of upper respiratory tract infections (URTIs). A meta-analysis indicated a risk ratio of 0.78 [95% CI 0.68-0.88] for preventing URTIs, suggesting a moderate protective effect. Another study reported a relative risk of 0.75 [95% CI 0.69–0.81] for preventing respiratory tract infections. Some evidence suggests it may also alleviate the severity of cold symptoms. These benefits are most pronounced in healthy individuals using Echinacea preventatively or at the onset of symptoms. However, the quality of evidence varies, and results can be inconsistent across different studies and preparations.
How it works
Echinacea is believed to modulate the immune system, potentially through the activation of macrophages and enhancement of cytokine production. It interacts with the immune system, possibly enhancing its function to combat infections. While specific molecular targets are not well-defined, it may influence various immune-related pathways. The bioavailability of Echinacea compounds varies depending on the preparation method, affecting its absorption and effectiveness. This immune modulation helps the body respond more effectively to upper respiratory tract infections.
Side effects
Echinacea is generally considered safe for short-term use. Common side effects include mild gastrointestinal complaints. Uncommon side effects include allergic reactions, which can manifest as skin rashes or itching. Serious adverse effects are rare. Echinacea may interact with immunosuppressants and other medications, so caution is advised. It is contraindicated in individuals with autoimmune diseases unless under medical supervision. Pregnant or breastfeeding women should exercise caution and consult a healthcare provider before use. Overall, Echinacea has a good safety profile when used appropriately, but awareness of potential side effects and interactions is important.
Dosage
Dosage varies widely depending on the specific Echinacea preparation. A typical range is 300-1200 mg per day, but it's essential to follow the manufacturer's instructions. For prevention, continuous use is common, while for treatment, it's often started at the onset of symptoms. Ethanolic extracts and pressed juices are frequently used forms. High doses are generally not recommended due to potential side effects. Bioavailability can be influenced by the extraction method used. There are no specifically identified required cofactors.
FAQs
Does Echinacea cure colds?
Echinacea may help prevent or shorten the duration of colds, but it is not a cure. It works by modulating the immune system to better fight off infections.
Is Echinacea safe?
Echinacea is generally safe for short-term use. However, individuals with autoimmune conditions should consult a healthcare provider before use.
When should I take Echinacea?
Start taking Echinacea at the first sign of cold symptoms or use it preventatively during cold and flu season for best results.
What results can I expect from taking Echinacea?
Echinacea may reduce the frequency and severity of upper respiratory tract infections, but individual results can vary.
Research Sources
- https://www.researchgate.net/publication/331884296_Echinacea_for_the_prevention_and_treatment_of_upper_respiratory_tract_infections_A_systematic_review_and_meta-analysis – This systematic review and meta-analysis found that Echinacea preparations may reduce the incidence of URTIs, although results varied across studies. The review highlights the heterogeneity in Echinacea products and study designs, contributing to the variability in observed effects.
- https://www.mdpi.com/2079-6382/13/4/364 – This randomized controlled trial (RCT) found that Echinacea reduced the incidence of respiratory tract infections in children, with significant reductions in antibiotic use. The study suggests that Echinacea could be a valuable tool in reducing antibiotic prescriptions for respiratory infections in pediatric populations.
- https://pubmed.ncbi.nlm.nih.gov/31126553/ – This study examined the effects of different Echinacea preparations on artificially induced rhinovirus infections, showing mixed results regarding efficacy. The research indicates that the effectiveness of Echinacea may depend on the specific preparation and the timing of administration in relation to the viral infection.
- https://www.cancerresearchuk.org/about-cancer/treatment/complementary-alternative-therapies/individual-therapies/echinacea – This resource provides general information about Echinacea, including its uses, potential benefits, and side effects. It serves as a reliable source for understanding the basic properties and applications of Echinacea in complementary and alternative medicine.
- https://www.researchgate.net/publication/353580564_A_systematic_review_on_the_effects_of_Echinacea_supplementation_on_cytokine_levels_Is_there_a_role_in_COVID-19 – This systematic review explores the effects of Echinacea supplementation on cytokine levels, investigating its potential role in COVID-19. The review aims to determine whether Echinacea can modulate the immune response in a way that could be beneficial in the context of viral infections.
Supplements Containing Echinamide

Patented Echinamide Clinical Strength Triple-Standardized
Natural Factors

Echinamide Echinacea & Goldenseal Extract Tincture
Natural Factors

Echinamide Throat Spray Formula With Propolis
Natural Factors

Patented Echinamide Active Defense Honey Lemon Syrup
Natural Factors

Patented Echinamide Clinical Strength Triple-Standardized Potency
Natural Factors

Echinamide
Natural Factors

Pure Food Horseradish Respiratory Support
Natural Factors Whole Earth & Sea

Anti-V Formula With Clinically Proven Echinamide
Natural Factors

Anti-V Formula with Clinically Proven Echinamide
Natural Factors

Horseradish Respiratory Support
Natural Factors Whole Earth & Sea

Echinamide Active Support Honey Lemon Syrup
Natural Factors