Dipeptide Diaminobutyroyl Benzylamide Diacetate
Also known as: Syn-ake, Dipeptide diaminobutyroyl benzylamide diacetate, UNII-38H206R00R, Dipeptide Diaminobutyroyl Benzylamide Diacetate
Overview
Dipeptide diaminobutyroyl benzylamide diacetate, commonly known as Syn-ake, is a synthetic peptide primarily used in cosmeceutical products for its anti-aging properties. It is designed to mimic the effects of neurotoxins, such as waglerin, by acting as an antagonist of the muscular nicotinic acetylcholine receptor (nAChR). This peptide is not derived from natural sources and is chemically stable and soluble in aqueous solutions, making it suitable for various cosmetic formulations like creams, gels, and serums. Its primary application is to reduce muscle contractions, thereby decreasing the appearance of wrinkles. Research on Syn-ake is still in its early stages, with most studies focusing on dermatological applications rather than comprehensive clinical trials. The available evidence is mainly based on in vitro studies and small-scale clinical trials.
Benefits
The primary purported benefit of Dipeptide Diaminobutyroyl Benzylamide Diacetate is the reduction of wrinkles by mimicking the effects of Botox, reducing muscle contractions. Potential secondary benefits include improved skin texture and hydration, particularly when combined with ingredients like hyaluronic acid. These benefits are generally targeted towards individuals seeking non-invasive anti-aging treatments. However, specific effect sizes and clinical significance are not well-documented in peer-reviewed literature, and the onset and duration of these benefits are not clearly established. More rigorous research is needed to quantify these effects and determine their clinical relevance.
How it works
Dipeptide diaminobutyroyl benzylamide diacetate functions as an antagonist of the muscular nicotinic acetylcholine receptor (nAChR), similar to neurotoxins like waglerin. By interacting with the nervous system, it modulates muscle contractions, which can reduce the formation of wrinkles. The primary molecular target is the nAChR, which plays a crucial role in muscle contraction. While the peptide is stable and soluble, specific data on its absorption and bioavailability in human skin remains limited. Encapsulation techniques, such as liposomes, may enhance skin penetration.
Side effects
Dipeptide diaminobutyroyl benzylamide diacetate is generally considered safe for topical use, but comprehensive safety data is limited. Common, uncommon, and rare side effects are not well-documented in peer-reviewed literature. No significant drug interactions or contraindications have been specifically noted. Due to limited information, caution should be exercised when used by pregnant or breastfeeding women. Users should monitor for any adverse reactions following topical application. Further research is needed to fully understand the safety profile and potential adverse effects associated with its use.
Dosage
A minimum effective dose, optimal dosage ranges, and maximum safe dose for Dipeptide Diaminobutyroyl Benzylamide Diacetate are not established in peer-reviewed literature. It is typically used in concentrations suitable for cosmetic formulations, but specific optimal ranges are not documented. No specific timing recommendations are available. It is commonly used in creams, gels, and serums. Encapsulation techniques like liposomes may enhance skin penetration. No required cofactors are specifically noted. Further research is needed to determine appropriate dosage guidelines and safety thresholds.
FAQs
Is Dipeptide Diaminobutyroyl Benzylamide Diacetate a substitute for Botox?
No, while it may mimic Botox-like effects by reducing muscle contractions, it is not a substitute for medical treatments like Botox injections. It offers a non-invasive alternative with potentially milder effects.
Is Dipeptide Diaminobutyroyl Benzylamide Diacetate safe for topical use?
It is generally considered safe for topical use, but users should monitor for any adverse reactions. Comprehensive safety data is limited, so caution is advised, especially for pregnant or breastfeeding women.
How often should I apply products containing this peptide?
There is no specific guidance on the timing or frequency of application. Follow the instructions provided on the product label. Consistency is key, but monitor your skin for any signs of irritation.
What kind of results can I expect from using this peptide?
Users may expect some reduction in the appearance of wrinkles, but results can vary. It is not a guaranteed solution, and individual responses may differ. Manage expectations accordingly.
Is Dipeptide Diaminobutyroyl Benzylamide Diacetate a neurotoxin?
No, it is not a neurotoxin itself. It is a synthetic peptide designed to mimic certain effects of neurotoxins by acting on acetylcholine receptors, but it does not have the same mechanism or risks.
Research Sources
- https://www.mdpi.com/2079-9284/11/4/118 – This study explores the use of biomimetic peptides in cosmeceuticals, including dipeptide diaminobutyroyl benzylamide diacetate. It discusses their mechanisms of action and potential benefits in skin rejuvenation. The research highlights the role of these peptides in targeting specific biological pathways to improve skin health.
- https://jddonline.com/articles/clinical-evidence-of-dermal-and-epidermal-restructuring-from-a-biologically-active-growth-factor-ser-S1545961619P0290X/?_page=2 – This article presents clinical evidence of dermal and epidermal restructuring using biologically active growth factors. While not solely focused on dipeptide diaminobutyroyl benzylamide diacetate, it provides context on the broader use of peptides in skincare and their potential to improve skin structure and appearance. The study suggests that peptides can stimulate collagen production and enhance skin elasticity.
- https://www.creative-peptides.com/article/function-of-dipeptide-diaminobutyroyl-benzylamide-diacetate-in-skin-76.html – This article discusses the function of dipeptide diaminobutyroyl benzylamide diacetate in skin, highlighting its role in reducing muscle contractions and minimizing the appearance of wrinkles. It explains the mechanism by which the peptide interacts with neuromuscular junctions to produce a Botox-like effect. The article emphasizes its potential as a non-invasive alternative for anti-aging treatments.
- https://ijdvl.com/content/126/2017/83/1/Images/ijdvl_2017_83_1_9_186500.pdf – This resource provides a visual representation or image related to dermatological applications, potentially including the use of dipeptide diaminobutyroyl benzylamide diacetate. While the specific context is limited without the full article, it suggests the peptide's relevance in dermatological treatments and research. Further investigation of the associated study would be needed for detailed insights.
- https://pubchem.ncbi.nlm.nih.gov/compound/Dipeptide-diaminobutyroyl-benzylamide-diacetate – This entry from PubChem provides chemical and structural information about dipeptide diaminobutyroyl benzylamide diacetate. It includes details such as its molecular formula, molecular weight, and other identifiers. This information is useful for understanding the chemical properties and composition of the peptide.