Diosvein
Also known as: Hesperidin, Diosmin + Hesperidin, Micronized Purified Flavonoid Fraction (MPFF), Daflon®
Overview
Hesperidin is a flavonoid glycoside prominently found in the peels of citrus fruits such as oranges and lemons. As a bioactive compound, it is often used in conjunction with diosmin to create the Micronized Purified Flavonoid Fraction (MPFF), a formulation known as Daflon®. Hesperidin exhibits several health-promoting properties, including anti-inflammatory, antioxidant, and venotonic effects. It is primarily indicated for managing venous insufficiency and associated disorders, with moderate to high levels of evidence supporting its efficacy through various systematic reviews and clinical trials. The primary natural sources are citrus peels, and it is also available in concentrated supplement forms, enhancing its clinical relevance.
Benefits
Hesperidin, particularly when administered as MPFF, has been shown to significantly alleviate symptoms of chronic venous insufficiency, with research indicating that around 92.5% of patients experience improvement within 90 days of treatment. Beyond venous health, hesperidin positively affects cardiovascular risk markers, decreasing triglycerides, total cholesterol, and LDL cholesterol when taken at doses of approximately 1,000 mg/day over extended periods. Secondary benefits include improved quality of life scores among patients suffering from chronic venous issues. Evidence strength ranges from moderate to high, with clinical trials indicating significant but varied effect sizes, particularly in specific populations suffering from chronic venous diseases.
How it works
Hesperidin and its combination with diosmin primarily exert their effects through venotonic and anti-inflammatory mechanisms. They enhance venous tone and reduce capillary permeability while inhibiting inflammatory mediators. This interaction predominantly influences the vascular system, improving blood circulation and mitigating edema. The micronized formulation enhances bioavailability, promoting better absorption and therapeutic efficacy. Although the exact molecular interactions are not fully clarified, they likely involve the modulation of endothelial function and inflammatory pathways.
Side effects
Hesperidin is generally well-tolerated; however, some individuals may experience side effects. Commonly reported adverse effects (>5%) include gastrointestinal disturbances such as nausea and diarrhea. Uncommon occurrences (1-5%) may include headaches, dizziness, and allergic reactions. Rare side effects (<1%) can encompass severe allergic reactions, though these are infrequently reported. Patient populations must be cautious about potential drug interactions, particularly with anticoagulants or other medications affecting blood clotting. Contraindications include known allergies to flavonoids, as well as severe kidney or liver conditions. Pregnant or breastfeeding individuals should consult healthcare providers prior to use.
Dosage
For optimal results, the recommended dosage of MPFF (Daflon®) typically is 1,000 mg/day, comprising 900 mg of diosmin and 100 mg of hesperidin. A minimum effective dose of around 500 mg/day of hesperidin has shown some efficacy, with higher doses (1,000 mg) resulting in more pronounced benefits, particularly in cardiovascular health. Users should note that effects on venous insufficiency may begin to manifest within 90 days of supplementation, while cardiovascular improvements are best observed after more than six weeks. The micronized form significantly enhances bioavailability, and there are no specific co-factors required for effective absorption.
FAQs
Is hesperidin safe to use?
Hesperidin is generally regarded as safe when used properly, although monitoring for possible interactions and side effects is recommended.
How should hesperidin be taken?
It is best taken consistently for more than six weeks to achieve optimal benefits.
What results can I expect?
Patients typically experience improvements in venous insufficiency symptoms and may see reductions in cardiovascular risk factors.
Is hesperidin a cure for cardiovascular diseases?
No, it is neither a cure-all nor a substitute for medical treatment but can be an effective part of management plans for specific conditions.
Research Sources
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1177708/full – This systematic review and dose-response meta-analysis concluded that hesperidin significantly lowers triglycerides, total cholesterol, and LDL cholesterol at dosages around 1,000 mg/day for more than eight weeks.
- https://www.annphlebology.org/journal/view.html?doi=10.37923%2Fphle.2021.19.2.21 – In a randomized controlled trial involving 96 patients with chronic venous insufficiency, MPFF was shown to significantly improve quality of life and reduce transient venous reflux after 90 days of treatment.
- https://www.mdpi.com/1999-4923/17/1/59 – This meta-analysis examined alternative therapies for chronic venous insufficiency, including diosmin and hesperidin. It noted substantial variability in the effectiveness between studies but confirmed significant benefits compared to other treatments.
- https://jmla.pitt.edu/ojs/jmla/article/download/1223/1368 – This review assessed the overall safety and clinical effectiveness of flavonoids, underscoring hesperidin's favorable safety profile and efficacy in managing venous disorders.
- https://www.tandfonline.com/doi/full/10.2147/VHRM.S324112 – This clinical study outlined the therapeutic potential of micronized purified flavonoid fractions, particularly focusing on their role in alleviating symptoms of chronic venous insufficiency, supported by clinical evidence.
Supplements Containing Diosvein
Vein Support
Doctor's Best
Vessel Forte
Designs for Health
Ultimate Vitamin C
Purity Products
Varico Vein
Country Life
Nice Legs!
Bronson
VeinAid
Bronson
Love My Legs
Irwin Naturals
VeinFactors
Futurebiotics
VeinAid
Bronson