DILL EXTRACT
Also known as: Dill, Dill extract, Anethum graveolens
Overview
Dill extract, derived from the herb Anethum graveolens, is a botanical supplement traditionally used in culinary and medicinal practices. It is primarily investigated for its potential to modulate cardiovascular risk factors, particularly lipid profiles. Key characteristics include its antioxidant, anti-inflammatory, and lipid-lowering properties. Research on dill extract is moderately mature, with several randomized controlled trials (RCTs) and meta-analyses supporting its efficacy. The evidence quality is considered moderate, with some noted heterogeneity across studies. It is commonly utilized for its potential to improve blood lipid levels, making it a subject of interest for individuals with metabolic syndrome or those at risk for cardiovascular disease. The extract is available in various forms, including powders and concentrated extracts, and its effects are typically observed after consistent, long-term use.
Benefits
Dill extract supplementation has demonstrated significant benefits in improving lipid profiles, particularly in adults with cardiovascular risk factors. Meta-analyses of randomized controlled trials indicate that supplementation for more than six weeks can lead to a reduction in triglycerides by approximately 29.2 mg/dL, total cholesterol by about 16.46 mg/dL, and low-density lipoprotein cholesterol (LDL-C) by 13.9 mg/dL. Concurrently, it has been shown to increase high-density lipoprotein cholesterol (HDL-C) by 4.01 mg/dL. These effects are statistically significant and clinically relevant, suggesting a strong evidence base for its lipid-modulating properties. Additionally, some studies report secondary benefits such as improvements in glycemic indices (fasting blood glucose, insulin resistance) and reductions in inflammatory markers like IL-6, TNF-α, and CRP. These benefits are most pronounced in individuals with cardiovascular risk factors or metabolic syndrome, with effects typically becoming apparent after at least 6 weeks of consistent supplementation.
How it works
Dill extract exerts its effects through various bioactive compounds, including flavonoids, phenolic acids, and essential oils. These compounds possess potent antioxidant and anti-inflammatory properties, which contribute to its therapeutic actions. The lipid-lowering effects are believed to stem from the modulation of enzymes involved in cholesterol synthesis and clearance within the body. By influencing these metabolic pathways, dill extract can help regulate blood lipid levels. Its anti-inflammatory properties may also play a role in reducing systemic inflammation, a known contributor to cardiovascular risk. The absorption and bioavailability of these active compounds are generally sufficient to elicit systemic effects in humans, allowing them to interact with relevant biological systems.
Side effects
Dill extract is generally considered safe, with clinical trials reporting no serious adverse events. Mild and rare side effects may include gastrointestinal discomfort. There are no significant drug interactions or contraindications documented in the current literature. However, caution is advised when combining dill extract with prescribed lipid-lowering medications, as comprehensive interaction data are still limited. For specific populations such as pregnant women, breastfeeding mothers, or children, there is insufficient research to establish definitive safety conclusions, and therefore, its use is not recommended without medical supervision. Individuals with known allergies to plants in the Apiaceae family (e.g., celery, carrot, parsley) should also exercise caution due to potential cross-reactivity.
Dosage
Effective doses of dill extract, as observed in clinical studies, typically range from approximately 900 mg to 3 grams of dill powder or extract daily. To achieve improvements in lipid profiles, a minimum duration of at least 6 weeks of consistent supplementation is necessary. While there is no established maximum safe dose, the doses used in trials have been well tolerated. The timing of supplementation relative to meals or other supplements is not clearly defined in the current research. It is important to note that formulations can vary (e.g., powder, concentrated extract), and this may influence bioavailability and, consequently, the effective dosage. Users should adhere to product-specific recommendations or consult a healthcare professional for personalized guidance, especially when considering higher doses or long-term use.
FAQs
How long does it take to see effects from dill extract?
Significant improvements in lipid profiles are typically observed after at least 6 weeks of consistent daily supplementation with dill extract.
Is it safe to take dill extract with other medications?
No major drug interactions have been documented, but caution is advised, especially with lipid-lowering drugs. Always consult a healthcare professional before combining supplements with medications.
Can dill extract replace prescribed statins or other lipid-lowering medications?
No, dill extract should not replace prescribed lipid-lowering medications. It may serve as a complementary therapy but always under the guidance of a healthcare professional.
Research Sources
- https://ccbjournal.ssu.ac.ir/article_128.html – This meta-analysis of randomized controlled trials investigated the effects of dill extract on lipid profiles. It found significant reductions in triglycerides, total cholesterol, and LDL-C, along with an increase in HDL-C, after more than 6 weeks of supplementation in adults with cardiovascular risk factors. The study concluded that dill extract is effective in improving lipid parameters.
- https://publish.kne-publishing.com/index.php/CCB/article/view/5870 – This source appears to be a duplicate or related publication to the Mansoori et al. 2021 meta-analysis. It confirms the findings of significant improvements in lipid profiles (TG, TC, LDL, HDL) with dill extract supplementation, supporting its role in managing cardiovascular risk factors. The evidence quality was moderate with some heterogeneity.
- https://journals.lww.com/nutritiontodayonline/fulltext/2023/05000/dill__potential_health_benefits.9.aspx – This systematic review by Singletary (2023) comprehensively examined the health benefits of dill. It highlighted dill's positive effects on lipid profiles, glycemic control, and inflammatory markers, suggesting its potential as a natural agent for managing cardiovascular risk factors. The review noted variability in study designs and doses, recommending further high-quality research.
- https://pubmed.ncbi.nlm.nih.gov/33624557/ – This systematic review and meta-analysis by Mousavi et al. (2022) confirmed the lipid-lowering and glycemic benefits of dill supplementation. It emphasized dill's potential as an adjunct therapy for metabolic syndrome, reinforcing the findings from other studies. The authors underscored the need for larger, high-quality randomized controlled trials to draw more definitive conclusions.
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