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Deglycyrrhized Licorice

Also known as: Deglycyrrhizinated Licorice, DGL, Glycyrrhiza glabra (without glycyrrhizic acid)

Overview

Deglycyrrhizinated Licorice (DGL) is derived from the root of the plant *Glycyrrhiza glabra*, having had the glycyrrhizic acid removed to mitigate potential side effects commonly associated with licorice, such as hypertension. DGL is primarily used in herbal remedies for gastrointestinal health, particularly for conditions like acid reflux and peptic ulcers. It is typically available in forms such as chewable tablets, capsules, or powder. The key characteristics of DGL include its lack of glycyrrhizic acid, making it a safer alternative for individuals sensitive to the effects of traditional licorice. Research has indicated some potential benefits of DGL in relieving symptoms of gastroesophageal reflux disease (GERD) and promoting mucosal healing in the digestive tract, although comprehensive and high-quality evidence remains limited.

Benefits

DGL is noted for potential benefits in alleviating gastrointestinal discomfort, particularly symptoms linked to GERD and peptic ulcers. Some studies suggest that DGL may help soothe the digestive tract by promoting the repair of the gastric lining. A small-scale study indicated possible improvements in GERD symptoms. However, due to the limited size and quality of existing clinical trials, the strength of these benefits is not robustly established. DGL may also exhibit antioxidant properties through its flavonoid components, which could contribute to additional health benefits, though specific populations that would benefit the most are not clearly identified in the literature.

How it works

The exact mechanism of action for DGL is not fully understood, but it is believed to promote mucosal healing by enhancing the secretion of mucus in the gastrointestinal tract. Flavonoids in DGL, such as glabridin, are thought to contribute antioxidant activity, which may reduce inflammation and promote tissue repair. This interaction potentially supports protective effects on the stomach lining, thereby mitigating irritation caused by gastric acids. The lack of glycyrrhizic acid is critical, as this removal decreases the risk of adverse cardiovascular effects associated with regular licorice.

Side effects

Overall, DGL is considered safe for most users, particularly when compared to its glycyrrhizic acid-containing counterpart. Common side effects are not well-documented but may include mild gastrointestinal upset in some individuals. Rare side effects have not been thoroughly reported in the literature. There are no well-established drug interactions; however, caution may be warranted when used with medications affecting gastrointestinal motility. Pregnant and breastfeeding women should avoid DGL due to a lack of safety data in these populations. Since DGL lacks glycyrrhizic acid, it is less likely to cause elevated blood pressure or fluid retention, which are associated risks of regular licorice.

Dosage

The optimal dosage of DGL varies depending on the form of the supplement. Typical recommendations suggest taking 300 to 1,000 mg of DGL extract daily, divided into two or three doses, preferably taken before meals to maximize its potential benefits for digestive issues. The form of DGL, such as chewable tablets or capsules, may influence absorption rates. It is essential to adhere to the manufacturer's suggested guidelines and consult with a healthcare professional to determine an appropriate dose, especially for long-term use. Due to limited safety data, there is no specific upper limit set for DGL consumption.

FAQs

Is DGL safe for long-term use?

While DGL is generally considered safer than regular licorice due to the absence of glycyrrhizic acid, long-term safety has not been extensively studied. It is advisable to use caution and consult a healthcare professional.

How should DGL be taken for best results?

DGL is typically taken in capsule or chewable tablet form, before meals. For maximum efficacy, follow dosage guidelines provided by the manufacturer or a healthcare provider.

Can DGL help with acid reflux?

Some studies suggest that DGL can help alleviate symptoms associated with acid reflux, but the evidence is not robust. Individual responses may vary.

Are there any dietary restrictions while taking DGL?

There are no specific dietary restrictions associated with DGL, but maintain a balanced diet to support overall gut health.

Can DGL be taken with other medications?

DGL is not well-studied for drug interactions. Consult a healthcare provider before combining it with other medications, especially for gastrointestinal issues.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/29433679/ – This study explored the potential benefits of a formula containing DGL for GERD symptoms. Results indicated improvements, but the study lacked a placebo control, limiting its reliability.
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Licorice-Flavonoids-Cognitive-Vitality-For-Researchers.pdf – This resource outlines the cognitive and gastrointestinal benefits of licorice flavonoids, suggesting potential effects of DGL; however, it emphasizes the need for more specific studies on DGL.
https://www.medicalnewstoday.com/articles/dgl-for-acid-reflux – An article detailing the uses of DGL for acid reflux and its mechanism, but also noting the mixed evidence from various studies, underscoring the necessity for further research.
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/licorice – This source discusses the uses and safety profile of licorice, highlighting that DGL is preferred for those sensitive to glycyrrhizic acid. It provides an overview of potential adverse effects and dosing considerations.