De111 Bacillus Subtillis
Also known as: Bacillus subtilis DE111, DE111 probiotic
Overview
Bacillus subtilis DE111 is a specific, spore-forming probiotic strain of the Gram-positive bacterium Bacillus subtilis, commonly found in soil and the mammalian gastrointestinal tract. Its unique spore-forming ability allows it to survive the harsh acidic environment of the stomach and reach the intestines intact, where it can exert its beneficial effects. Primarily, DE111 is utilized to support digestive health, balance the gut microbiome, and enhance immune function. Research indicates its efficacy in reducing gastrointestinal symptoms, modulating immune responses, and positively altering gut flora by increasing beneficial bacteria and inhibiting pathogenic ones. It is considered a well-researched probiotic with a moderate to high level of scientific evidence supporting its applications.
Benefits
Bacillus subtilis DE111 offers several evidence-based benefits, particularly for gastrointestinal health and immune function. It significantly reduces the duration of gastrointestinal symptoms such as vomiting and hard stools in children, with one study showing a reduction in hard stool duration from 15 days to 0 days (p=0.044) and overall discomfort from 48 days to 18 days (p=0.0499). This indicates strong evidence for its role in alleviating digestive distress. Furthermore, DE111 supports immune health by increasing specific antibody production and modulating cytokine levels. While not significantly reducing the incidence of respiratory infections in all studies, some trends suggest protective effects. It also positively impacts the gut microbiome by increasing beneficial bacteria like Lactobacillales and reducing pro-inflammatory bacteria such as Eisenbergiella. These benefits are particularly relevant for children, who experience reduced incidence and duration of gastrointestinal infections, and athletes, who may benefit from immune support during intense training. A meta-analysis in broiler chickens even showed improved average daily gain and final body weight, comparable to antibiotics in treating necrotic enteritis, highlighting its broad applicability. Benefits on gastrointestinal health are typically observed within 8 weeks of consistent daily intake.
How it works
Bacillus subtilis DE111 primarily works through several key mechanisms within the gastrointestinal tract. Its spore-forming nature ensures survival through stomach acid, allowing it to reach the intestines where it germinates. Once active, it interferes with pathogens by inhibiting their growth, adhesion, and displacement, partly through the production of antimicrobial substances. DE111 also modulates the gut microbiome by increasing the population of beneficial bacteria while reducing pathogenic or pro-inflammatory species. This rebalancing of the gut flora contributes to improved digestive health. Furthermore, it interacts with the immune system by increasing specific antibody production and modulating cytokine levels, thereby enhancing the body's immune response. The overall effect is a healthier gut environment and a more robust immune system.
Side effects
Bacillus subtilis DE111 is generally considered safe for consumption, with a favorable safety profile. Clinical studies have reported no significant adverse events attributable to the probiotic. Any adverse events observed were similar in both probiotic and placebo groups, suggesting they were unrelated to DE111 intake. There are no documented common (>5%), uncommon (1-5%), or rare (<1%) side effects specifically linked to this strain. No significant drug interactions have been reported. While no specific contraindications have been identified, caution is advised for individuals with severe immunodeficiency or chronic illnesses, as with any probiotic. It is generally considered safe for special populations like children and athletes, but individuals with underlying health conditions should consult a healthcare professional. Overall, the available research indicates a high level of safety for Bacillus subtilis DE111.
Dosage
The minimum effective dose for Bacillus subtilis DE111 is typically 1 x 10^9 CFU (Colony-Forming Units) per day. This dosage has been consistently used in clinical trials demonstrating its benefits. While no maximum safe dose has been definitively established, doses exceeding 1 x 10^9 CFU per day have not been extensively studied, so adhering to the recommended range is prudent. For consistent benefits, daily intake is recommended. DE111 is available in various forms, including capsules and powders, but its spore form is crucial for enhanced stability and survival through the gastrointestinal tract, ensuring effective delivery to the intestines. No specific cofactors are required to enhance its efficacy, as its spore-forming nature inherently optimizes its absorption and action within the gut.
FAQs
Is Bacillus subtilis DE111 safe to take?
Yes, it is generally considered safe. Clinical studies have reported no significant adverse effects, with any observed issues being similar to those in placebo groups.
How should I take Bacillus subtilis DE111?
Daily intake of 1 x 10^9 CFU is recommended for consistent benefits. It can be taken at any time of day, often found in capsule or powder form.
What benefits can I expect from taking DE111?
You can expect improved gastrointestinal health, including reduced duration of symptoms like vomiting and hard stools, and potential support for your immune system.
How long does it take to see benefits?
Benefits on gastrointestinal health have been observed within 8 weeks of consistent daily intake in clinical studies.
Is DE111 a replacement for medication?
No, DE111 is a dietary supplement intended to support health, not to diagnose, treat, cure, or prevent any disease. It should not replace medical treatment.
Research Sources
- https://e49e4bcf719d5ffce39c-f9fa0626754b99f92250fafa303db91e.ssl.cf3.rackcdn.com/Online%20Events/PB21/Deerland-DE111-whitepaper.pdf – This white paper provides a comprehensive overview of Bacillus subtilis DE111, detailing its characteristics, mechanisms of action, and various health benefits. It highlights the strain's ability to survive the GI tract due to spore formation, its role in modulating the gut microbiome, and its positive impact on immune function and gastrointestinal health.
- https://www.longdom.org/open-access-pdfs/effect-of-daily-bacillus-subtilis-de111-intake-on-gastrointestinalhealth-and-respiratory-infections-in-children-attendin.pdf – This randomized, double-blind, placebo-controlled study investigated the effect of daily Bacillus subtilis DE111 intake on gastrointestinal health and respiratory infections in 102 children. It found a significant reduction in the duration of gastrointestinal symptoms like vomiting and hard stools, but no significant difference in the incidence of respiratory infections.
- https://pubmed.ncbi.nlm.nih.gov/37494807/ – This meta-analysis evaluated the efficacy of Bacillus subtilis as a replacement for in-feed antibiotics in broiler chickens across 28 studies. It concluded that B. subtilis improved average daily gain and final body weight, demonstrating comparable efficacy to antibiotics in treating necrotic enteritis, although antibiotics were more effective in reducing mortality rates.
- https://brill.com/view/journals/bm/11/7/article-p611_1.xml?language=en – This randomized, double-blind, placebo-controlled study, involving 102 children, examined the impact of daily Bacillus subtilis DE111 intake on the gut microbiome. It revealed positive changes, including an increase in beneficial bacteria and a reduction in pro-inflammatory bacteria, supporting a healthier gut environment in children.