Dang Gui Extract
Also known as: Dang Gui, Dong Quai, Chinese Angelica, Angelica sinensis
Overview
Dang Gui, or *Angelica sinensis*, is a plant native to China, historically used in Traditional Chinese Medicine (TCM) primarily for women's health issues such as menstrual disorders and to improve blood circulation. The extract is derived from the root of the plant and is known for its potential anti-inflammatory, antioxidant, and cardiovascular benefits. Its research maturity is moderate, with increasing studies aimed at understanding its efficacy and safety, although the available evidence remains variable, with some high-quality systematic reviews and meta-analyses suggesting positive effects.
Benefits
Dang Gui is indicated for various health benefits, especially in women's health and cardiovascular conditions. Evidence suggests that when used in formulations like Danggui Buxue Decoction, it significantly improves red blood cell count and hematocrit levels in patients with renal anemia, with studies indicating an odds ratio for clinical efficacy at 0.30 (95% CI: 0.13, 0.69). Further research supports its use for menstrual health and anti-inflammatory effects, particularly in women facing menstrual irregularities, demonstrating a clinical significance over controls. Noticeable benefits may develop within several weeks to months of consistent use.
How it works
The primary mechanisms of action for Dang Gui involve its anti-inflammatory and antioxidant properties, possibly enhancing blood circulation and reducing oxidative stress. It is believed to interact primarily with the cardiovascular and reproductive systems, modulating inflammatory mediators and vascular function, although specific molecular targets remain poorly defined due to limited data on absorption and bioavailability.
Side effects
Dang Gui is generally considered safe when used appropriately. Common side effects (greater than 5%) may include gastrointestinal upset and allergic reactions, while less common effects (1-5%) can include skin rash and dizziness, and rare occurrences (<1%) may involve severe allergic reactions. Caution is warranted with concurrent use of anticoagulants and antiplatelet medications, and it is contraindicated during pregnancy and breastfeeding due to lacking safety data. Special populations, including those with bleeding disorders or on blood thinners, should consult healthcare professionals before use.
Dosage
Dosage recommendations for Dang Gui are not definitively established. A common approach includes using decoctions or extracts containing 1-3 grams of dried root per day. Optimal dosages can vary based on specific formulations and conditions. There are no clearly defined maximum safe doses, and high doses could increase the risk of side effects. It's advisable to take Dang Gui with meals to minimize gastrointestinal issues, and it is available in various forms including capsules, tablets, and teas. Factors affecting absorption may include preparation methods used.
FAQs
Can I use Dang Gui with my medications?
It's advisable to consult a healthcare provider before using Dang Gui, especially if you're on other medications due to potential interactions.
How should I take Dang Gui for best results?
Taking Dang Gui with meals may help minimize gastrointestinal side effects and improve tolerance.
How soon can I expect results from Dang Gui?
Benefits may vary, but many users report improvements within several weeks to months of consistent use.
Is Dang Gui safe during pregnancy?
Dang Gui is not recommended during pregnancy or breastfeeding due to insufficient safety data.
Can Dang Gui replace my current medication?
No, Dang Gui should not be used as a substitute for conventional medical treatment without consulting a healthcare provider.
Research Sources
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1375795/full – This systematic review and meta-analysis highlights the efficacy of Danggui Sini Decoction, showcasing significant improvements in angina symptoms among coronary heart disease patients when used alongside conventional treatments.
- https://journals.lww.com/md-journal/fulltext/2020/01240/danggui_shaoyao_san_for_dementia__a.5.aspx – The study assesses the efficacy of Danggui Buxue Decoction in renal anemia, revealing notable improvements in red blood cell counts and hematocrit levels when combined with standard Western medicine.
- https://atm.amegroups.org/article/view/13926/html – This meta-analysis reviews interactions and implications of various herbal medicines, including Dang Gui, stressing caution due to documented side effects and interactions with other medications.
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