Cutch Tree Bark Extract
Also known as: Cutch Tree, Khair, Catechu, Acacia wood extract, Acacia catechu
Overview
Acacia catechu, known as the Cutch Tree, is an Asian tree prominent in India and Southeast Asia. Its bark and wood extracts are rich in bioactive compounds, notably flavonoids, phenols, and polyphenols. Historically, Acacia catechu has been utilized in Ayurvedic medicine for its potential anti-inflammatory, antimicrobial, and antidiabetic properties. The extract is commonly used as a natural dye in the food industry. Despite promising in vitro and animal studies demonstrating its health benefits, there is a notable lack of comprehensive clinical trials in humans. Consequently, uncertainties regarding its dosage recommendations, efficacy, and safety profile necessitate further investigation in human studies. The extract is mostly available in ethanolic form.
Benefits
Research has highlighted several potential benefits of Acacia catechu. Its anti-inflammatory effects are supported by in vitro studies that show it can prevent protein denaturation, an effect comparable to diclofenac sodium. Additionally, the extract exhibits notable antimicrobial properties and potential antioxidant capabilities attributed to its polyphenol content. Preliminary studies have also indicated possible antidiabetic effects; however, these mostly derive from laboratory investigations or animal studies. Comprehensive clinical validation is critically needed to confirm efficacy and to determine specific populations that may benefit the most from its use.
How it works
The anti-inflammatory properties of Acacia catechu are primarily attributed to its ability to inhibit protein denaturation, thus modulating the inflammatory response. The flavonoids and polyphenols present in the extract may interact with various inflammatory signaling pathways. However, the exact biological mechanisms, molecular interactions, and pharmacokinetics in human physiology are still not fully understood, emphasizing the importance of further studies on its absorption and bioavailability in humans.
Side effects
The safety profile of Acacia catechu is not well-defined, largely due to insufficient human clinical studies. Available data from in vitro and animal research generally suggest that the extract is safe when used correctly. However, conclusive evidence regarding specific side effects is lacking, and no rare adverse effects or established contraindications have been reported thus far. Caution should be exercised concerning possible drug interactions, which remain to be comprehensively studied. Until more definitive safety data is available, individuals considering its use should proceed with care.
Dosage
Currently, there is no universally accepted dosage for Acacia catechu for human consumption due to inadequate clinical trial data. In vitro investigations have tested concentrations ranging from 200 to 1000 µg/mL, but the translation of these findings into effective human dosages remains uncertain. Furthermore, safety thresholds and upper limits for human dosage have yet to be established, highlighting the urgent need for further research to clarify effective dosing and absorption profiles for practical applications in humans.
FAQs
Is Cutch Tree Extract safe for human use?
While in vitro studies indicate safety, human clinical trials are necessary for confirmation.
How should Cutch Tree Extract be taken?
There are no specific guidelines for timing or administration; further studies are needed.
What effects can I expect from Cutch Tree Extract?
Expected benefits include anti-inflammatory effects based on in vitro data, but clinical efficacy is not well established.
Can I use Cutch Tree Extract in place of medication?
No, it should not substitute for medical treatment until clinical evidence supports its use.
Supplements Containing Cutch Tree Bark Extract
Re-Feed Extreme Chocolate
GNC Beyond Raw
Amplified Total Muscle Recovery Chocolate
GNC Pro Performance AMP
Re-Built Mass Vanilla Cake Batter
GNC Beyond Raw
Re-Power Orange
GNC Beyond Raw
Re-Power Fruit Punch
GNC Beyond Raw
Re-Feed Vanilla Cake Batter
GNC Beyond Raw
Re-Grow Vanilla Cream
GNC Beyond Raw
Re-Grow Chocolate
GNC Beyond Raw
Re-Built Mass Triple Chocolate Cake
GNC Beyond Raw
Re-Built Mass Strawberry Milkshake
GNC Beyond Raw
Re-Built Mass Cookies & Cream
GNC Beyond Raw
Amplified Total Muscle Recovery Vanilla
GNC Pro Performance AMP
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