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Copper Bisglycinate Chelate

Also known as: Copper Glycinate, Copper Bis-Glycinate, Copper Bisglycinate Chelate

Overview

Copper Bisglycinate Chelate is a synthetic compound used as a mineral supplement to enhance copper bioavailability. It is formed by binding copper to glycine, an amino acid, which facilitates improved absorption and utilization in the body. Copper is an essential trace mineral naturally found in foods like shellfish, nuts, and legumes, playing a crucial role in various physiological functions, including immune support, connective tissue health, and enzyme activity. As a chelated form, copper bisglycinate is designed to overcome the absorption limitations associated with inorganic copper salts. While research on copper bisglycinate is growing, more extensive human studies are needed to fully validate its benefits and optimal usage. It is available in various supplement forms, including capsules and tablets, and is often chosen for its potentially gentler impact on the gastrointestinal system compared to other copper forms.

Benefits

Copper bisglycinate chelate is primarily recognized for its enhanced bioavailability, which supports several key health functions. Studies, such as one conducted on steers, indicate that copper bisglycinate has a relative bioavailability of 82% compared to copper sulfate, based on liver copper levels, suggesting improved absorption. This enhanced absorption supports immune function by aiding in the production and activity of immune cells. Additionally, copper is a cofactor for numerous enzymes involved in energy production, antioxidant defense (e.g., superoxide dismutase), and connective tissue maintenance. While some research suggests potential benefits for cardiovascular health and antioxidant activity, further human studies are necessary to confirm these effects. Individuals with copper deficiency or those seeking enhanced immune support may particularly benefit from copper bisglycinate supplementation.

How it works

Copper bisglycinate chelate works by providing a highly bioavailable form of copper, an essential trace mineral. Copper acts as a cofactor for several enzymes crucial for various physiological processes. These enzymes are involved in energy production (cytochrome c oxidase), antioxidant defense (superoxide dismutase), and the synthesis of connective tissues. By chelating copper with glycine, absorption is enhanced, allowing copper to be more efficiently transported across the intestinal wall and utilized by the body. This supports the immune system, nervous system, and the maintenance of healthy connective tissues. Copper's role in these pathways makes it vital for overall health and well-being.

Side effects

Copper bisglycinate chelate is generally considered safe when taken as directed, but it can cause side effects in some individuals. Common side effects include gastrointestinal upset, such as nausea or stomach discomfort. Uncommon side effects may involve copper toxicity if excessive doses are consumed, potentially leading to liver damage or neurological issues. Drug interactions can occur, particularly with zinc supplements, as high copper intake can lead to zinc deficiency. It is contraindicated in individuals with Wilson's disease or other conditions affecting copper metabolism. Pregnant or breastfeeding women should consult healthcare providers before using copper supplements. The Tolerable Upper Intake Level (UL) for copper is 10 mg per day, and exceeding this amount can increase the risk of adverse effects. Monitoring intake and adhering to recommended dosages is crucial to minimize risks.

Dosage

The optimal dosage of copper bisglycinate chelate typically falls within the range of 0.9 to 1.3 mg per day for adults, aligning with the recommended dietary allowance for copper. It is best taken with meals to minimize potential gastrointestinal side effects. As a chelated form, copper bisglycinate may offer better absorption compared to inorganic copper salts. The Tolerable Upper Intake Level (UL) for copper is 10 mg per day, and exceeding this limit should be avoided to prevent toxicity. While no specific cofactors are explicitly required, maintaining adequate zinc intake is important to prevent imbalances. Individual needs may vary, and consulting with a healthcare provider is advisable to determine the appropriate dosage.

FAQs

How should I take copper bisglycinate chelate?

It is recommended to take copper bisglycinate chelate with meals to minimize potential gastrointestinal side effects. Consistent timing can help maintain steady copper levels in the body.

Is copper bisglycinate chelate safe?

When taken within recommended dosages, copper bisglycinate chelate is generally safe. Excessive intake can lead to toxicity, so it's important to adhere to recommended dosages and not exceed the Tolerable Upper Intake Level (UL).

What are the expected benefits of taking copper bisglycinate chelate?

The expected benefits include enhanced immune function and enzyme activity, though individual results may vary. Copper supports various physiological processes, contributing to overall health.

Can copper bisglycinate chelate cure diseases?

No, copper bisglycinate chelate is not a cure for diseases. It supports overall health by acting as a cofactor for enzymes and aiding in various bodily functions.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC8188816/ – This study on steers demonstrated that copper bisglycinate had a relative bioavailability of 82% compared to copper sulfate, based on liver copper levels. The findings suggest that chelation with glycine enhances copper absorption and utilization in animals, which may translate to similar benefits in humans.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7037088/ – This review discusses the biological roles of copper and its importance in human health. It highlights copper's function as a cofactor for enzymes involved in various physiological processes, including antioxidant defense and energy production, emphasizing its essential role in maintaining overall health.
https://www.mdpi.com/1420-3049/30/6/1282 – This in vitro study explores the immunomodulatory effects of copper bisglycinate. The research suggests that copper bisglycinate can influence immune function, supporting its potential role in enhancing immune responses, although further in vivo studies are needed to confirm these effects.
https://onlinelibrary.wiley.com/doi/10.1002/jbt.70052?af=R – This article discusses the applications of metal-amino acid chelates in animal nutrition. It highlights the enhanced bioavailability of chelated minerals, including copper, and their benefits for animal health, providing insights into the potential advantages of using copper bisglycinate in human supplements.
https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1217748/full – This review explores the role of copper in cardiovascular health. It discusses how copper deficiency can contribute to cardiovascular issues and highlights the importance of adequate copper intake for maintaining cardiovascular function, suggesting a potential link between copper bisglycinate supplementation and heart health.