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Coleus Forskohlii Extract Powder

Also known as: Indian coleus, makandi, pashanabhedi, Coleus forskohlii

Overview

Coleus forskohlii is a plant native to India and Southeast Asia, traditionally used in Ayurvedic medicine for its potential beneficial effects on cardiovascular and respiratory health. The primary active compound is forskolin, a diterpenoid that is derived from the root of the plant. Forskolin is known for its ability to activate adenylate cyclase, leading to increased cyclic AMP (cAMP) levels in the body. This specific action can potentially improve various physiological functions such as cardiovascular health, metabolic processing, and respiratory conditions. Research on Coleus forskohlii is still in the preliminary phases, with most studies being small-scale and short-term, highlighting the necessity for more extensive clinical trials to definitively establish its efficacy and safety.

Benefits

Coleus forskohlii has been linked to several potential health benefits. Evidence supports its role in enhancing cardiovascular health, with studies indicating improvements in coronary blood flow, myocardial function, and reduced blood pressure. Moreover, forskolin has shown promise in promoting weight loss, demonstrating significant reductions in body fat and improvements in body composition, particularly in overweight and obese men. Additionally, its utility in managing asthma has been indicated by clinical data suggesting a reduction in asthma attacks in patients. Overall, the evidence for these benefits is derived mainly from small clinical trials, warranting caution and the need for larger studies to corroborate these outcomes.

How it works

Forskolin primarily activates adenylate cyclase (AC), subsequently increasing levels of cyclic AMP (cAMP) within cells. This increase in cAMP plays a crucial role in mediating various physiological responses, leading to enhanced cardiovascular functions, improved insulin sensitivity, and modulation of inflammatory responses. The interaction with AC directly influences the cardiovascular system, promoting coronary blood flow and potentially aiding in blood pressure regulation. Furthermore, its effects on insulin sensitivity and metabolic pathways could promote fat loss and improve body composition.

Side effects

Coleus forskohlii is generally considered safe for most individuals at recommended doses; however, some side effects may occur. Common adverse effects reported (greater than 5% incidence) include gastrointestinal disturbances, particularly diarrhea. Less frequently (1-5% incidence), individuals may experience increased stomach acid levels or inhibition of platelet aggregation, which could pose risks for those on anticoagulant therapies. There are no well-documented rare side effects (less than 1% incidence), but due caution is advised for individuals with low blood pressure or clotting disorders. Pregnant or breastfeeding women and individuals with certain medical conditions should consult a healthcare professional before using this supplement.

Dosage

Recommended dosages of Coleus forskohlii extract typically start at 250 mg standardized to 10% forskolin, taken twice daily. The most studied effective dose is 500 mg per day, providing approximately 50 mg of forskolin. While there's no definitive upper safe limit established, exceeding 500 mg per day may increase the risk of side effects due to limited research on higher dosages. There are no specific timing recommendations, and absorption can be affected by its low solubility and bioavailability. Regular oral forms are common in studies, and factors influencing its effectiveness do not require specific cofactors.

FAQs

Is Coleus forskohlii safe?

Generally safe at recommended doses, though gastrointestinal side effects may occur, and interactions with certain medications are possible.

When should I take Coleus forskohlii?

There are no specific timing recommendations; it is usually taken twice daily.

What results can I expect?

Potential improvements in body composition, insulin sensitivity, and cardiovascular health may be observed, albeit results can vary.

Is it effective for weight loss?

While some studies indicate weight loss benefits, it is not a guaranteed solution and individual results may vary.

Research Sources

https://www.drugs.com/npp/forskolin.html – This resource provides an overview of forskolin's clinical uses and safety profile, detailing various studies that point towards its cardiovascular benefits, although emphasizing the need for more rigorous research.
https://www.researchgate.net/publication/301234875_An_evidence-based_review_Anti-obesity_effects_of_Coleus_forskohlii – This article reviews the anti-obesity effects of Coleus forskohlii, noting significant outcomes regarding weight loss and fat mass reduction in clinical studies, while also pointing out limitations in research quality.
https://examine.com/supplements/coleus-forskohlii/ – Examine.com provides a detailed analysis of Coleus forskohlii, discussing its potential benefits related to weight loss and cardiovascular health, while addressing key research findings and safety considerations.
https://www.thecompoundingshoppe.com/blog/2023/5/4/weight-loss – This blog highlights the use of Coleus forskohlii in weight loss supplements, encapsulating the current evidence while stressing the necessity for further studies to validate effectiveness.
https://www.researchgate.net/publication/268441079_Coleus_forskohlii_A_comprehensive_review_on_morphology_phytochemistry_and_pharmacological_aspects – This comprehensive review covers the morphology and pharmacological aspects of Coleus forskohlii, evaluating its phytochemistry and preliminary data on a variety of health benefits.