Coix Lacryma Jobi Seed Extract
Also known as: Job's Tears, Adlay, Coix Seed, Coix lacryma-jobi
Overview
Coix lacryma-jobi seed extract is derived from the seeds of the *Coix lacryma-jobi* plant, a member of the Poaceae family. Traditionally used in Chinese medicine, it has gained popularity for its anti-inflammatory, anti-tumor, and immunomodulatory effects. The extract contains various bioactive compounds including polysaccharides, fatty acids, and flavonoids, which contribute to its pharmacological activity. While research on its effects is growing, it currently rests at a moderate level of maturity, predominantly supported by traditional use and emerging studies, some of which back its application as an adjunct therapy in cancer treatment.
Benefits
Coix lacryma-jobi demonstrates notable anti-tumor effects, particularly beneficial for patients undergoing chemotherapy, wherein it has been shown to improve survival rates and quality of life. Additionally, it possesses anti-inflammatory and immunomodulatory properties, potentially aiding in the management of various inflammatory conditions. Other observed benefits include hypoglycemic effects, liver function improvement, and regulation of intestinal microbiota. Though specific effect sizes for these benefits remain under-documented, clinical significance has been noted in cancer treatment outcomes, with improvements observed during the course of chemotherapy.
How it works
The anti-tumor effects of Coix lacryma-jobi seed extract are likely mediated through modulation of immune responses, along with potential direct cytotoxic effects on cancer cells. Its anti-inflammatory properties may involve the suppression of pro-inflammatory cytokines, thereby positively influencing overall immune system function. The extract interacts with various body systems, including the immune and gastrointestinal systems. However, specific molecular targets and detailed biological pathways remain inadequately defined.
Side effects
Coix lacryma-jobi is generally considered safe with appropriate use, although comprehensive safety data is limited. Reported side effects are not well-documented, but gastrointestinal disturbances may occur. Uncommon and rare side effects have not been specifically reported. There may be potential drug interactions with chemotherapy agents, yet it is often used to mitigate their side effects rather than as a primary treatment. Caution is advised in special populations such as pregnant or lactating women due to insufficient safety data in these groups.
Dosage
Optimal dosage ranges for Coix lacryma-jobi seed extract are not well-established, and specific effective doses vary, especially when used as an adjunct in cancer treatment. It is traditionally used in conjunction with chemotherapy, but minimum and maximum safe doses have not been clearly defined. It can be found in various forms including extracts and injections, and its bioavailability may be influenced by individual gastrointestinal health. Without established required cofactors, it is recommended that individuals consult healthcare providers for personalized dosing.
FAQs
Is Coix lacryma-jobi safe to use with other medications?
Generally safe, but consult a healthcare provider, especially if combining it with chemotherapy or other treatments.
How should Coix lacryma-jobi be taken?
Typically administered concurrently with chemotherapy, as specific timing guidelines vary by individual treatment plans.
What benefits can I expect from using Coix lacryma-jobi?
Users may experience improved cancer treatment outcomes and reduced chemotherapy side effects, though results may vary.
Can I use Coix lacryma-jobi as a primary cancer treatment?
No, it should not be viewed as a replacement for conventional cancer treatments, but rather as a complementary option.
Are there any known interactions with Coix lacryma-jobi?
Potential interactions with chemotherapy drugs may occur; monitoring for interactions is recommended.
Research Sources
- https://journals.lww.com/md-journal/fulltext/2020/08070/efficacy_and_safety_of_kanglaite_injection_for.64.aspx – This systematic review examines the efficacy and safety of Kanglaite injection in gastric cancer treatment, though results are pending publication.
- https://pubmed.ncbi.nlm.nih.gov/37858750/ – A literature review that discusses the medicinal properties of Coix seed, emphasizing its pharmacological effects including anti-tumor and hypoglycemic activities, but notes a lack of comprehensive clinical trials.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.901875/full – This overview of systematic reviews and meta-analyses demonstrates the use of Kanglaite as an adjunctive therapy in cancer, showing improved survival rates and quality of life indicators.
- https://www.mdpi.com/1422-0067/25/21/11828 – This article provides insights into bioactive compounds in Coix seed, discussing effects on various health conditions and emphasizing the need for further clinical research.
- https://www.mdpi.com/2072-6643/13/11/4079 – A study highlighting the nutritional aspects of Coix lacryma-jobi and its potential health benefits, reinforcing its traditional medicinal use but pointing out gaps in clinical data.