Coffeeberry Soluble Extract 40%
Also known as: Coffeeberry extract, coffee fruit extract, coffee cherry extract, Coffea arabica extract, Coffea canephora extract, Coffeeberry Soluble Extract
Overview
Coffeeberry Soluble Extract 40% is a standardized botanical extract derived from the whole fruit of Coffea species, primarily Coffea arabica or Coffea canephora. It is characterized by its high content of soluble polyphenols, standardized to approximately 40%, with chlorogenic acids being the main active compounds. This extract is primarily marketed for its potential benefits in cognitive enhancement, antioxidant support, and metabolic health. While animal studies suggest promising anti-obesity and anti-diabetic effects, human clinical evidence for significant cognitive or mood benefits at typical doses is limited and mixed. The extract is available as a dietary supplement ingredient, with research maturity being moderate, indicating a need for more comprehensive human trials to confirm its efficacy across various applications.
Benefits
The benefits of Coffeeberry Soluble Extract are still being investigated, with varying strengths of evidence: - **Cognitive and Mood Effects:** A 2023 randomized controlled trial (RCT) found no significant improvement in mood, mental or physical energy, episodic memory, or cognitive tasks at doses of 100 mg or 300 mg. However, another study reported alerting effects at a higher dose (1100 mg), though cognitive performance benefits were limited. The evidence for robust cognitive enhancement is currently not strong. - **Metabolic Effects:** Preclinical animal studies have shown dose-dependent anti-obesity, anti-diabetic, and lipid-lowering effects. These studies indicated improved pancreatic weight and function in high-fat diet mice, with some parameters comparable to metformin. While promising, these findings require confirmation through human clinical trials, particularly for individuals with metabolic syndrome or prediabetes. - **Antioxidant and Anti-inflammatory Effects:** The polyphenols, especially chlorogenic acids, present in coffeeberry extract possess antioxidant properties. These may contribute to reducing oxidative stress and inflammation within the body. However, direct clinical evidence specifically demonstrating these effects in humans from coffeeberry extract supplementation is limited.
How it works
Coffeeberry Soluble Extract's primary mechanism of action is attributed to its rich content of chlorogenic acids and other polyphenols. These compounds act as potent antioxidants, neutralizing free radicals and reducing oxidative stress. In terms of metabolic function, they are believed to modulate glucose metabolism, potentially improving insulin sensitivity and reducing lipid accumulation, possibly through anti-inflammatory pathways. For neurocognitive function, the polyphenols may influence cerebral blood flow and neurotransmitter systems, although the exact pathways and their impact on cognitive performance are not yet conclusively established. Upon ingestion, chlorogenic acids are moderately absorbed, with their metabolites, such as phenolic acids and urolithins, detectable in plasma and contributing to the extract's bioactive effects.
Side effects
Coffeeberry Soluble Extract appears to have a favorable safety profile, with no serious adverse events reported in human clinical trials at studied doses up to 1100 mg acutely. One randomized controlled trial noted mild, transient negative mood effects at a lower dose of 100 mg, but these were not observed at 300 mg. No significant drug interactions or contraindications have been documented in the clinical studies conducted to date. However, specific populations such as pregnant or lactating women, and children, have not been specifically studied, so caution is advised for these groups. As with any supplement, individuals with pre-existing medical conditions or those taking other medications should consult a healthcare professional before use. The overall safety assessment suggests it is generally well-tolerated, but further research on long-term use and potential interactions is warranted.
Dosage
The optimal dosage for Coffeeberry Soluble Extract varies depending on the desired effect and is not fully established for all applications. For acute alerting effects, a dose of 1100 mg has been observed to be effective. However, lower doses, such as 100-300 mg, have shown no significant cognitive benefits in some randomized controlled trials. For metabolic effects, while animal studies suggest promising results with dose equivalents roughly corresponding to 200 mg extract or higher, the optimal human dose has not yet been established. The extract should be standardized to 40% polyphenols for consistent efficacy. Acute effects are typically studied within 1-2 hours post-dose, but data on chronic dosing and its timing are currently lacking. It is important to adhere to recommended dosages and consult with a healthcare professional for personalized advice.
FAQs
Does coffeeberry extract improve cognition?
Limited evidence suggests that high doses (e.g., 1100 mg) may improve acute alertness, but robust benefits for overall cognitive performance are not consistently demonstrated at typical supplement doses.
Is coffeeberry extract safe?
Yes, it is generally well-tolerated in studies, with no major side effects reported at doses up to 1100 mg. Mild, transient negative mood effects were noted at 100 mg in one study.
When should I take coffeeberry extract?
Acute effects have been studied within 1-2 hours post-dose. There is currently no specific data or recommendations for the timing of chronic use.
Will coffeeberry extract help with weight loss or diabetes?
Promising animal data suggest potential anti-obesity and anti-diabetic effects. However, human clinical trials are needed to confirm these benefits in people.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10254646/ – This double-blind, placebo-controlled RCT investigated the acute effects of 100 mg and 300 mg Coffeeberry Soluble Extract on mood, energy, and cognitive performance in adults. It found no significant improvements in these parameters and noted transient negative mood effects at the 100 mg dose, suggesting limited cognitive benefits at these levels.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10812732/ – This animal study (mice) demonstrated that Coffeeberry Soluble Extract exhibited dose-dependent anti-obesity and anti-diabetic effects. It improved pancreatic weight and function, with some parameters comparable to metformin, highlighting its potential for metabolic health benefits in preclinical models.
- https://pubs.acs.org/doi/10.1021/acs.jafc.3c01142 – This research focuses on the absorption and metabolism of chlorogenic acids, the primary bioactive compounds in coffeeberry extract. It indicates moderate absorption and the formation of bioactive metabolites like phenolic acids and urolithins, which are detectable in plasma post-consumption.
- https://www.informahealthcare.com/doi/epub/10.1080/1028415X.2021.1963068?needAccess=true – This acute RCT reported alerting effects at a high dose of 1100 mg of coffeeberry extract. While it indicated some impact on alertness, the study noted limited cognitive performance benefits, suggesting that very high doses might be required for noticeable acute effects.