CLEANSE Complex Proprietary Blend
Also known as: CLEANSE Complex Proprietary Blend, Liver Cleanse, Detox Blend, Digestive Support Complex
Overview
CLEANSE Complex Proprietary Blend is a mixture of ingredients marketed for liver detoxification, digestive support, and general wellness. These blends typically contain various herbs, plant extracts, and sometimes vitamins or minerals. Common ingredients may include milk thistle (Silybum marianum), dandelion root (Taraxacum officinale), and turmeric (Curcuma longa), though the exact composition is not disclosed. A key characteristic of these blends is the lack of transparency regarding ingredient amounts and ratios, which can lead to variable product quality and efficacy. Research on individual ingredients may exist, but there is very little research on proprietary blends as a whole. Evidence for individual ingredients is mixed and often limited by small sample sizes, short durations, and methodological weaknesses. Therefore, there is no high-quality evidence supporting the efficacy or safety of proprietary blends as a whole.
Benefits
There is no robust evidence from randomized controlled trials (RCTs) or meta-analyses that supports specific health benefits for CLEANSE Complex Proprietary Blend as a whole. Some studies suggest modest improvements in liver enzyme levels from individual ingredients like milk thistle, but the effect sizes are small and the clinical significance is uncertain. Limited evidence suggests potential antioxidant or anti-inflammatory effects from individual components, but not for the blend itself. No evidence supports population-specific benefits. Effect sizes for individual ingredients are generally small, such as small reductions in ALT/AST with milk thistle, but these are not consistently clinically significant. The time course of benefits is not established for the blend; for milk thistle, effects may be seen after several weeks to months, but data are inconsistent.
How it works
Individual ingredients in CLEANSE Complex Proprietary Blend may act via antioxidant, anti-inflammatory, or hepatoprotective pathways. For example, silymarin in milk thistle may modulate NF-κB and other inflammatory pathways. The blend primarily interacts with the liver and digestive system, and some ingredients may affect the gut microbiota. Absorption and bioavailability vary by ingredient; phospholipid formulations of milk thistle may improve bioavailability. However, because the exact composition and concentrations of the blend are not disclosed, it is difficult to determine the specific mechanisms of action and interactions of the blend as a whole.
Side effects
CLEANSE Complex Proprietary Blend is generally considered safe for most individuals when used as directed, but safety data for proprietary blends are lacking. Common side effects include mild gastrointestinal upset, such as nausea and diarrhea. Uncommon side effects include allergic reactions to herbal ingredients. Rare side effects include severe allergic reactions or hepatotoxicity. Potential drug interactions exist with medications metabolized by the liver, such as CYP450 substrates; therefore, consulting a healthcare provider is advised. Contraindications include pregnancy, lactation, and known allergies to any component. Use with caution in individuals with liver disease or those taking multiple medications.
Dosage
The minimum effective dose, optimal dosage ranges, and maximum safe dose are not established for CLEANSE Complex Proprietary Blend. For milk thistle, typical doses range from 140–800 mg silymarin per day, with 200–400 mg silymarin per day being common. Up to 800 mg/day of milk thistle is generally considered safe. It is typically taken with meals to reduce gastrointestinal side effects. Phospholipid formulations may improve bioavailability for milk thistle. Fat-soluble ingredients may be better absorbed with food. Due to the lack of transparency regarding ingredient amounts, it is difficult to provide specific dosage recommendations for the blend as a whole.
FAQs
Is CLEANSE Complex Proprietary Blend safe?
It is generally safe for most, but consult a healthcare provider if taking medications or have underlying health conditions due to potential interactions and the lack of ingredient transparency.
When should I take CLEANSE Complex Proprietary Blend?
Take it with meals to minimize gastrointestinal side effects. However, without knowing the specific ingredients and their optimal timing, this is a general recommendation.
What results can I expect from taking CLEANSE Complex Proprietary Blend?
There is no robust evidence for significant health benefits; any effects are likely to be modest and variable. Claims of 'detox' or 'cleanse' are not well-supported.
Why is ingredient transparency important?
Lack of ingredient transparency makes it difficult to assess efficacy, safety, or potential interactions with medications or other supplements.
Can CLEANSE Complex Proprietary Blend help with liver detoxification?
The liver naturally detoxifies the body. While some ingredients may support liver health, there is no high-quality evidence that this blend significantly enhances detoxification.
Research Sources
- https://journals.lww.com/ajg/fulltext/9900/liver_cleansing_imposters__an_analysis_of_popular.1664.aspx – This analysis of commercial products found that most liver “cleansing” supplements, including proprietary blends, lack transparency and robust evidence for efficacy or safety. The study provides insight into market practices but does not assess clinical outcomes, focusing instead on product labeling and marketing.
- https://ods.od.nih.gov/factsheets/WeightLoss-HealthProfessional/ – This systematic review and meta-analysis, focused on weight loss supplements, highlights that most supplement blends contain multiple ingredients, making it difficult to isolate effects. The evidence for individual ingredients is limited and often inconclusive, which is a principle applicable to other proprietary blends.
- https://www.innerbody.com/best-milk-thistle-supplement – This systematic review and product analysis indicates that milk thistle (silymarin) may modestly improve liver enzyme levels, but effect sizes are small and clinical significance is uncertain. It also notes that phospholipid formulations can improve bioavailability of milk thistle, though the overall evidence remains mixed.
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