Citrus Sinensis Fruit Extract
Also known as: Orange, Sweet Orange, Citrus sinensis
Overview
Citrus sinensis, commonly known as sweet orange, is a citrus fruit that is rich in flavonoids, limonoids, and other bioactive compounds. It is primarily consumed in various forms, including fresh fruit, juice, and as an extract in dietary supplements. This extract is known for its potential health benefits, particularly in cardiovascular health, weight management, and improving endothelial function. Key flavonoids in *Citrus sinensis*, such as naringenin and hesperidin, demonstrate strong antioxidant properties and may contribute to various health benefits. The research surrounding *Citrus sinensis* fruit extract is moderately mature, replete with systematic reviews and meta-analyses. Overall, the evidence is of moderate to high quality, although certain studies highlight limitations such as small sample sizes or limited intervention durations.
Benefits
The primary benefits of *Citrus sinensis* fruit extract include significant improvements in cardiovascular health, as evidenced by enhanced endothelial function and reduced total cholesterol levels. A meta-analysis indicated a weighted mean difference of 2.75% in flow-mediated vasodilation (FMD) with citrus flavonoids supplementation (p < 0.001). The extract also plays a role in weight management, as shown in a systematic review that noted reductions in body weight and waist circumference. The improvements in endothelial function were consistent across various populations, including those with cardiovascular risk factors. Overall, the evidence suggests that the extract may offer several clinically relevant benefits, particularly when used consistently over time.
How it works
*Citrus sinensis* fruit extract works through multiple biological pathways, primarily by improving endothelial function via enhanced nitric oxide production and reducing oxidative stress. The flavonoids present in the extract influence lipid metabolism, potentially by inhibiting enzymes related to cholesterol synthesis and increasing bile acid excretion. The interaction of flavonoids with cardiovascular and metabolic pathways contributes significantly to its protective effects, including improvements in vascular function and inflammation reduction. Notably, pathways such as endothelial nitric oxide synthase (eNOS) and peroxisome proliferator-activated receptors (PPAR) are important targets for these compounds.
Side effects
Overall, *Citrus sinensis* is regarded as safe for consumption when taken in moderate amounts. However, potential adverse effects may include gastrointestinal symptoms such as nausea, diarrhea, or stomach discomfort, which could affect more than 5% of users. Rarer side effects include allergic reactions, though instances are uncommon. Notably, high doses or long-term use may increase the risk of adverse events. Additionally, individuals on blood thinners, diabetes medications, or other cardiovascular drugs may experience interactions due to the flavonoid content. It is advised that individuals with known allergies to citrus or specific medical conditions consult a healthcare professional prior to use. Pregnant or breastfeeding women should exercise caution as limited data on safety in these populations exist.
Dosage
The recommended dosage range for *Citrus sinensis* extract generally falls between 200 mg to 1 gram per day, with 200 mg being identified as the minimum effective dose for cardiovascular benefits. No specific timing is mandated, though taking the supplement with meals is typically recommended to enhance absorption. There is no formally established maximum safe dose, but dosages above 1 gram per day lack extensive study and could heighten the risk for adverse effects. Various forms of the extract are available, including capsules, tablets, and beverages like orange juice, each with differing bioavailability profiles. Enhanced absorption may occur in the presence of certain nutrients like vitamin C or fatty acids.
FAQs
Is *Citrus sinensis* safe to use?
Generally safe when consumed in recommended doses, but may cause gastrointestinal side effects in some individuals.
When is the best time to take *Citrus sinensis* extract?
There is no specific timing required; taking it with meals may improve absorption.
What benefits can I expect from *Citrus sinensis* extract?
You may experience improvements in endothelial function, lipid profiles, and weight management over time.
Is *Citrus sinensis* a quick fix for health issues?
No, consistent use alongside a balanced lifestyle is necessary for optimal results.
Research Sources
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.822678/full – This systematic review investigates the impact of citrus flavonoids on endothelial function through a meta-analysis, demonstrating significant improvements in flow-mediated vasodilation (FMD) among populations studied.
- https://www.researchgate.net/publication/340000668_Dietary_citrus_andor_its_extracts_intake_contributed_to_weight_control_Evidence_from_a_systematic_review_and_meta-analysis_of_13_randomized_clinical_trials – This systematic review and meta-analysis evaluate dietary citrus intake’s role in weight management, revealing significant body weight and waist circumference reductions across several randomized clinical trials.
- https://pubmed.ncbi.nlm.nih.gov/38561995/ – This article addresses the effects of orange juice consumption on cardiovascular risk factors, noting significant reductions in cholesterol levels and improvement in insulin sensitivity.
- https://academic.oup.com/nutritionreviews/article/82/9/1292/7272715?login=false – This review discusses the nutritional benefits and health impacts of citrus fruits, including insights on flavonoid content and its beneficial effects on metabolic health.
- https://pubmed.ncbi.nlm.nih.gov/34060162/ – This publication explores the therapeutic properties of citrus extracts, highlighting their potential health benefits through various biological pathways including cholesterol management.
Supplements Containing Citrus Sinensis Fruit Extract
Ritual-PM
Ambrosia
CEO Pre-Workout
RYSE Supplements
ULTIMATE WEIGHT CONTROL
HAPPY MANN®
ULTIMATE WEIGHT CONTROL™
HAPPY MAMMOTH™
ULTIMATE® PRE-WORKOUT RARE KNUCKLE BLOOD ORANGE
WWE® ULTIMATE®
ULTIMATE GLP-1™
HAPPY MAMMOTH®
CITRAPEAK CAPSULES
BOWMAR NUTRITION
ULTIMATE WEIGHT CONTROL™
BEYOND ALPHA®
RYSE Core Loaded Pre-Workout Energy Supplement Powder - Country Time Lemonade
RYSE Supplements