Citrus Reticulata Peel Extract
Also known as: Citrus reticulata, Mandarin orange peel extract, Citrus peel extract, Citrus Reticulata Peel Extract
Overview
Citrus Reticulata Peel Extract is derived from the peel of the mandarin orange and is primarily composed of flavonoids and phenolic compounds, known for their strong antioxidant properties. The extract can be obtained through various methods, including supercritical fluid extraction, which enhances the recovery of these bioactive compounds. Research suggests that it may offer protective effects against oxidative stress and liver damage, as well as potential applications in managing physical fatigue and weight management, although the available evidence is limited and often based on animal studies rather than human trials.
Benefits
Citrus Reticulata Peel Extract has demonstrated antioxidant and anti-inflammatory benefits, particularly in reducing oxidative stress and liver damage in animal studies. One study indicated a significant reduction in liver injury markers in rats exposed to hepatotoxic agents. There is also some evidence suggesting that its bioactive compounds can help alleviate physical fatigue by interacting with the PI3K-AKT signaling pathway. While its role in weight management is not directly evidenced, the broader category of citrus fruits has shown mixed outcomes in weight control studies, signaling a potential but unconfirmed benefit.
How it works
The mechanism of action of Citrus Reticulata Peel Extract appears to be predominantly linked to its bioactive components such as flavonoids like Hesperetin and Sitosterol. These compounds modulate key signaling pathways, such as the PI3K-AKT pathway, which plays a role in the body's response to oxidative stress and physical fatigue. By influencing these biological processes, the extract may enhance antioxidant defenses and reduce inflammation.
Side effects
Citrus Reticulata Peel Extract is generally considered safe when consumed in moderate amounts; however, potential side effects may include gastrointestinal discomfort, skin allergies, and interactions with certain medications. Individuals hypersensitive to citrus fruits should exercise caution. No significant drug interactions have been identified, but it is advisable for pregnant or breastfeeding women to consult a healthcare provider before use. Overall, as more research is needed, the full range of side effects is not yet well-characterized.
Dosage
There is currently no standardized recommended dosage for Citrus Reticulata Peel Extract; however, studies suggest that dosages in the range of 500 mg to 1000 mg daily may provide benefits observed in animal models. Timing considerations alongside meals can enhance absorption and effectiveness. It is crucial to note that individual responses may vary, and exceeding recommended amounts could lead to adverse effects, so adhering to guidance from healthcare professionals is recommended.
FAQs
What are the main health benefits of Citrus Reticulata Peel Extract?
The primary health benefits include its antioxidant and anti-inflammatory effects, potential alleviation of physical fatigue, and possible contributions to weight management, though more human research is needed.
Are there any side effects associated with Citrus Reticulata Peel Extract?
Side effects may include gastrointestinal discomfort and skin allergies. Individuals with citrus sensitivities should be cautious when using this extract.
How should I take Citrus Reticulata Peel Extract?
There is no standardized dosage; however, 500 mg to 1000 mg daily is suggested based on animal studies, ideally taken with meals for better absorption.
Is Citrus Reticulata Peel Extract safe for pregnant women?
While generally safe, pregnant or breastfeeding women should consult a healthcare provider before using Citrus Reticulata Peel Extract.
Research Sources
- https://www.mdpi.com/2304-8158/13/11/1681 – This study discusses the extraction methods of Citrus Reticulata Peel and highlights its diverse bioactive compounds, focusing on antioxidant properties and potential health benefits.
- https://pubmed.ncbi.nlm.nih.gov/38350206/ – The research demonstrates that Citrus Reticulata Peel Extract effectively mitigates oxidative stress and liver damage in animal models, suggesting its protective potential against hepatotoxicity.
- https://academic.oup.com/nutritionreviews/article/82/9/1292/7272715?login=false – This review examines the role of flavonoids in citrus fruits, discussing their influence on health outcomes, including weight management and antioxidant capacity.
- https://pubmed.ncbi.nlm.nih.gov/38931288/ – The research highlights the physical fatigue alleviation potential of compounds found in Citrus Reticulata Peel Extract through targeted signaling pathways in network pharmacology studies.
- https://www.mdpi.com/2304-8158/13/13/1978 – This paper outlines the health benefits attributed to citrus peel extracts, emphasizing the need for further human trials to establish their efficacy more definitively.