Cistanche Root Extract
Also known as: Cistanche, Rou Cong Rong, Cistanche deserticola, Cistanche tubulosa
Overview
Cistanche is a parasitic plant primarily sourced from *Cistanche tubulosa* and *Cistanche deserticola*, often used in traditional Chinese medicine. This herbal supplement is known for its bioactive compounds like echinacoside and verbascoside, which contribute to its purported benefits including treatment for kidney deficiencies, impotence, and female infertility. Emerging research suggests potential applications in alleviating symptoms of chronic fatigue syndrome and enhancing cognitive function. Despite promising findings, the research maturity level for Cistanche remains moderate, with many studies limited by design and sample size.
Benefits
Cistanche shows potential benefits in several areas: 1) Chronic Fatigue Syndrome (CFS): A notable study indicated significant improvement in symptoms when combined with Ginkgo biloba, though effect sizes were small. 2) Infertility: It may enhance spermatogenic function and regulate hormones, suggesting advantageous effects on male reproductive health. 3) Antidepressant-like properties have been observed through modulation of gut microbiota. Evidence suggests these benefits may be particularly pronounced in males, with improvements seen within 60 days in specific studies.
How it works
Cistanche's benefits are attributed to its bioactive compounds, which exhibit antioxidant properties, modulate sex hormones, and influence gut microbiota. The primary pathways involve interactions with reproductive, nervous, and gastrointestinal systems, where its compounds, particularly phenylethanoid glycosides like echinacoside, may affect cellular targets influencing health conditions. However, detailed mechanisms of absorption and interaction remain inadequately understood.
Side effects
Cistanche is generally considered safe for most users, but high-quality studies on safety are lacking. Common side effects are not well-documented; however, gastrointestinal disturbances have been noted as uncommon. Rare side effects remain unknown. Professional guidance is recommended for individuals who are pregnant, nursing, or have kidney or liver concerns, as safety in these populations is uncertain. Limited data exists on drug interactions, thus caution is advised when combined with other medications.
Dosage
The minimum effective dose of Cistanche is approximately 300 mg per day, particularly for cognitive enhancement. For those dealing with CFS, an optimal dosage range of 300-450 mg per day has been suggested. Currently, maximum safe doses are not well-established. No specific timing for administration has been recommended, and it is typically consumed in the form of a water extract. There are no documented required cofactors for optimal absorption.
FAQs
Is Cistanche safe for long-term use?
While generally considered safe, there is insufficient research on the long-term safety of Cistanche, so consultation with a healthcare professional is advised.
How quickly can I expect to see results?
Some benefits, particularly for chronic fatigue, may be observed within 60 days of consistent use.
Can Cistanche help with infertility?
There is preliminary evidence suggesting Cistanche may improve aspects of male infertility, particularly regarding spermatogenic function.
Should I take Cistanche if I'm pregnant or breastfeeding?
Caution is advised, as the safety of Cistanche during pregnancy and lactation has not been established.
Is there any standard dosage for beginners?
Starting with a dosage of 300 mg per day is typically suggested for beginners before assessing individual response.
Research Sources
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.658630/full – This study presents a randomized controlled trial showing that Cistanche combined with Ginkgo biloba significantly improved symptoms of CFS in 190 adults, suggesting a potential therapeutic use.
- https://pubmed.ncbi.nlm.nih.gov/38718638/ – Review highlighting the efficacy of Cistanche in treating infertility, focusing on its antioxidant properties that may enhance reproductive functions.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00967/full – Discusses an animal study indicating that Cistanche tubulosa has antidepressant-like effects through its action on gut microbiota, suggesting mechanisms underlying its potential mental health benefits.
- https://pubmed.ncbi.nlm.nih.gov/36992906/ – This publication explores various properties of Cistanche, including its medicinal benefits and pharmacological effects, emphasizing the need for more extensive studies.
- https://onlinelibrary.wiley.com/doi/10.1155/2021/4936970 – Comprehensive review investigating Cistanche's biological effects and clinical applications, calling for further exploration into its therapeutic potential across various conditions.
