Cissus Quadrangularis Aerial Parts Extract
Also known as: Cissus quadrangularis L., Veldt Grape, Bone Setter, Cissus, Kankra, Cissus quadrangularis
Overview
Cissus quadrangularis is a succulent vine indigenous to Africa and Asia, traditionally utilized in Ayurvedic medicine for its various health benefits. This herb contains a rich profile of bioactive phytochemicals such as flavonoids and triterpenoids, which underpin its therapeutic applications, notably in bone and joint health. Research suggests that Cissus quadrangularis may effectively increase bone density, particularly beneficial for postmenopausal women, and has shown potential in aiding weight management for obese individuals. Typically, it is available in capsule or tablet forms, with varying concentrations of active constituents across products. This variation emphasizes the necessity for standardized formulations as research continues to advance.
Benefits
Cissus quadrangularis has been shown to have significant benefits, especially in promoting bone health. In randomized controlled trials, postmenopausal women experienced an average increase of 8.4% in bone mineral density after three months of supplementation, indicating strong efficacy in this group. Weight loss also stands out as a notable advantage, with studies reporting an average reduction of 4.9 kg in obese participants after eight weeks of daily usage. Preliminary studies suggest possible anti-inflammatory properties; however, more extensive evaluations in humans are warranted. The most pronounced effects are observed particularly in postmenopausal women and obese individuals, characterizing Cissus quadrangularis as a promising supplement for these populations.
How it works
Cissus quadrangularis functions mainly by inhibiting osteoclast activity, leading to reduced bone resorption while concurrently enhancing osteoblast activity, fostering bone formation. Regarding weight management, its effectiveness is associated with alterations in lipid metabolism and appetite regulation. The herb's bioactive compounds interact with various cellular signaling pathways, although data concerning their bioavailability remains limited, highlighting a necessary focus for future research.
Side effects
Cissus quadrangularis is generally considered safe when taken according to suggested dosages. Common minor side effects include gastrointestinal discomfort and nausea, reported by over 5% of users, while headaches and dizziness occur in 1-5% of cases. No severe adverse effects have been noted; however, caution is recommended for particular demographics. Possible interactions may arise with anticoagulants and diabetes medications, potentially influencing glucose levels and blood coagulation. Pregnant or breastfeeding women are advised against using this supplement, and those on diabetes or anticoagulant therapies should seek advice from healthcare practitioners due to insufficient safety data.
Dosage
The standard recommended dosage for Cissus quadrangularis aerial parts extract ranges from 500 mg to 3000 mg per day. An effective minimum dosage is around 500 mg daily, with most clinical studies reporting used dosages not exceeding 3000 mg without significant adverse effects. Timing is not strictly critical, though taking the supplement with meals is suggested to diminish gastrointestinal discomfort. Various formulations, including capsules and tablets, should ensure standardized levels of active constituents. Including dietary fats may enhance absorption and improve bioavailability.
FAQs
Is *Cissus quadrangularis* safe to use?
Generally safe for most people, monitor for gastrointestinal discomfort and possible interactions with other medications.
When is the best time to take *Cissus quadrangularis*?
Taking it with meals may help reduce gastrointestinal side effects.
How long does it take to see results?
Bone health improvements can be noticeable within 3 months, while weight loss effects are typically observed over several weeks.
Can I use it for quick weight loss?
It is not a quick fix; consistent use over several months is necessary for noticeable benefits.
Research Sources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626148/ – This systematic review highlights the efficacy of Cissus quadrangularis in improving bone mineral density, particularly among postmenopausal women. The analysis of various studies confirms significant increases in bone health, indicating strong support for its use in this demographic.
- https://pubmed.ncbi.nlm.nih.gov/24879758/ – A randomized controlled trial demonstrating the weight management effects of Cissus quadrangularis, showing an average weight reduction of 4.9 kg in participants after eight weeks, indicating its potential as a therapeutic supplement for obesity.