China
Also known as: Xianling Gubao Capsule, Longspur epimedium, Yin Yang Huo, Radix dipsaci, Xuduan, Salvia miltiorrhiza, Danshen, Rhizoma anemarrhenae, Zhimu, Rehmannia glutinosa, Dihuang, Psoralea corylifolia, Bu Gu Zhi, Xianling Gubao (XLGB) Capsule
Overview
Xianling Gubao (XLGB) Capsule is a Traditional Chinese Medicine (TCM) formula primarily used for the treatment of osteoporosis. It is approved by the China Food and Drug Administration. The capsule contains a blend of herbal extracts, including *Longspur epimedium* (Yin Yang Huo), *Radix dipsaci* (Xuduan), *Salvia miltiorrhiza* (Danshen), *Rhizoma anemarrhenae* (Zhimu), *Rehmannia glutinosa* (Dihuang), and *Psoralea corylifolia* (Bu Gu Zhi). These components contribute bioactive compounds such as icariin, quercetin, and luteolin. Research on XLGB is moderately mature, with increasing clinical trials conducted in China. However, the quality of available evidence varies, with some studies lacking rigorous randomization and blinding. XLGB is considered a TCM supplement aimed at improving bone health and overall quality of life.
Benefits
XLGB capsule primarily benefits bone health by promoting osteoblast differentiation and inhibiting osteoclast activity, which is particularly beneficial for individuals with osteoporosis. Studies have shown significant improvements in bone health markers, although the effect sizes can vary. Secondary benefits include enhanced quality of life and pain relief. Clinical trials in China support these positive effects on bone health, but more rigorous studies are needed for broader acceptance. Long-term use of XLGB may be required to achieve noticeable improvements in bone density and overall bone health.
How it works
XLGB capsule affects bone homeostasis by regulating osteoclasts and osteoblasts through multiple biological pathways. It targets the Wnt, TNF, MAPK, and PI3K-Akt pathways, influencing bone remodeling processes. Key molecular targets include STAT3, MAPK14, JUN, IL-2, and EGFR. These interactions help to promote bone formation and reduce bone resorption, contributing to improved bone density and strength. Specific data on the absorption and bioavailability of the capsule's components is limited, but the combined action of the herbal extracts is believed to contribute to its overall efficacy.
Side effects
While XLGB capsule is generally considered safe, comprehensive safety data is limited. Common side effects are not well-documented in the available literature, but there is potential for gastrointestinal upset. Rare side effects are unknown due to the lack of comprehensive safety studies. Due to the Danshen content, there is a potential for interactions with anticoagulants, and caution is advised in individuals with bleeding disorders. Pregnant and lactating women should use XLGB with caution. It is essential to consult with a healthcare provider before using XLGB, especially if taking other medications.
Dosage
Optimal dosage ranges for XLGB capsule typically follow traditional Chinese medicine dosing guidelines, as minimum effective and maximum safe doses are not well-defined in Western literature. Long-term use is generally recommended for osteoporosis management. The capsule form is standard. Bioavailability may vary based on the quality of the herbal extracts used in the formulation. There are no documented required cofactors for XLGB. It is crucial to adhere to the dosing instructions provided by a healthcare professional familiar with TCM practices.
FAQs
Should I consult a healthcare provider before using XLGB?
Yes, it is essential to consult a healthcare provider before using XLGB, especially if you are taking other medications, to avoid potential drug interactions or adverse effects.
Are there any safety concerns with XLGB?
Yes, there is a potential for drug interactions with anticoagulants due to the Danshen content. Caution is advised for individuals with bleeding disorders or those who are pregnant or breastfeeding.
How long should I take XLGB to see results?
Long-term use is typically necessary to achieve noticeable improvements in bone health and overall quality of life. It is not a quick fix, and consistent use as directed is important.
What are the expected benefits of taking XLGB?
The expected benefits include improved bone health, increased bone density, and enhanced quality of life over time. It works by promoting bone formation and reducing bone loss.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/36159792/ – This study investigates the protective effects of Xianling Gubao (XLGB) on bone marrow mesenchymal stem cells (BMSCs) under oxidative stress induced by H2O2. The research reveals that XLGB treatment significantly enhances cell viability, reduces apoptosis, and modulates the expression of key proteins involved in osteogenic differentiation, suggesting its potential in preventing osteoporosis by protecting BMSCs from oxidative damage.
- https://pmc.nlm.nih.gov/articles/PMC6266204/ – This review examines the efficacy and safety of traditional Chinese medicine (TCM) for treating osteoporosis, including Xianling Gubao (XLGB). It highlights that while TCM, including XLGB, shows promise in improving bone density and reducing fracture risk, the methodological quality of many studies is low. The review calls for more rigorous, well-designed clinical trials to validate these findings and establish clear guidelines for TCM use in osteoporosis management.
- https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.870277/full – This study explores the impact of total glucosides of epimedium (TGE), a major component of Xianling Gubao, on bone metabolism and osteoporosis. The research demonstrates that TGE can promote osteogenic differentiation and inhibit osteoclast formation by modulating various signaling pathways, including Wnt/β-catenin and MAPK pathways. These findings support the use of TGE and XLGB in the treatment of osteoporosis by enhancing bone formation and reducing bone resorption.
- https://www.mdpi.com/1660-4601/16/3/374 – This study investigates the effects of icariin, a flavonoid derived from the herb Epimedium (a component of Xianling Gubao), on bone regeneration. The research demonstrates that icariin promotes osteoblast differentiation and mineralization in vitro and enhances bone formation in vivo. These results suggest that icariin and Epimedium-containing formulations like XLGB may be beneficial for promoting bone regeneration and treating bone-related disorders.
- https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0278492 – This study assesses the effectiveness of Xianling Gubao (XLGB) in treating primary osteoporosis by analyzing its impact on bone mineral density (BMD) and bone turnover markers. The research indicates that XLGB treatment can significantly improve BMD and reduce bone turnover, suggesting its potential as a therapeutic option for osteoporosis. However, the study also emphasizes the need for larger, more rigorous trials to confirm these findings and establish its long-term efficacy and safety.
Supplements Containing China
Recommended Articles
Herbal Boosters & COVID-19 Antivirals: Safe Mix?
Herbal supplements may interact with COVID-19 antivirals, requiring careful consideration and further research.
Immune Supplements & Pregnancy Safety 2025
The safety of immune-boosting supplements during pregnancy in 2025 hinges on supplement type, dosage, and health conditions.
Top Immune Support Ingredients: What Works?
Vitamin D, zinc, and echinacea are key ingredients in immune support supplements, backed by scientific evidence.
Supplement Ingredients & Skin Reactions
Certain ingredients in dietary supplements can lead to skin reactions such as hives and dermatitis, notably from herbal supplements.