Chasteberry Seed Extract
Also known as: Chasteberry, Chaste Tree, Chastetree, Agnus Castus, *Vitex agnus-castus*
Overview
Chasteberry, derived from the fruit of the *Vitex agnus-castus* plant, is traditionally used to alleviate symptoms associated with premenstrual syndrome (PMS), menstrual irregularities, and a range of female reproductive disorders. Its use dates back to ancient times, with more recent studies exploring its effectiveness in addressing hormonal fluctuations and mood swings. Numerous clinical trials and systematic reviews have assessed chasteberry's efficacy, particularly for PMS, though the quality of evidence varies. While chasteberry is primarily considered safe and well-tolerated by many, it is important to note that the standardization of extracts and dosages can differ widely, impacting outcomes.
Benefits
Chasteberry has demonstrated significant benefits for women experiencing PMS. A meta-analysis indicated that women using chasteberry were 2.57 times more likely to achieve symptom remission compared to placebo, highlighting its potential for alleviating mood swings and physical discomfort associated with PMS (95% CI 1.52-4.35). Additionally, it may provide relief for cyclical breast pain and menstrual irregularities, although support for these claims is less robust. The strongest effects are reported in women with normal ovarian function and without significant hormone imbalances. Effect sizes indicate clinical significance, but further studies are needed to better understand the full spectrum of its benefits across various demographics.
How it works
The mechanism of action for chasteberry primarily involves its interaction with dopamine receptors, leading to altered prolactin levels and influence on menstrual cycle regulation. This plant extract may also engage in opioidergic activity through activation of mu- and delta-opioid receptors. By modulating these pathways, chasteberry can impact endocrine functions and hormone levels, particularly prolactin, affecting menstrual cycles and lactation in women.
Side effects
Chasteberry is generally regarded as safe, but mild side effects can occur, including nausea, headache, and gastrointestinal disturbances. Some individuals may experience menstrual disorders, acne, or itching, which are less common. Serious side effects are rare and not well-documented. Notably, chasteberry may interact with dopamine agonists or antagonists due to its dopaminergic effects, which could alter the efficacy or safety of these medications. It is contraindicated in pregnant and breastfeeding women because of potential impacts on lactation and fetal development. Caution is also advised for individuals with hormone-sensitive conditions, which could be influenced by hormonal modulation.
Dosage
The recommended dosage ranges for chasteberry are typically 20-40 mg of dried extract per day for the minimum effective dosage. An optimal dosage range of 40-80 mg per day is often suggested, but this can vary depending on the specific conditions being addressed. While a maximum safe dose is not well-established, there is a risk that high doses could decrease lactation. Chasteberry is usually taken daily throughout the menstrual cycle, and extracts that are standardized for casticin may enhance effectiveness. It's essential to monitor individual response, particularly at higher concentrations.
FAQs
What should I do if I experience side effects?
If side effects occur, consider reducing the dosage or discontinuing use. Consult a healthcare professional for guidance.
Is it safe to use chasteberry during pregnancy?
Chasteberry is not recommended during pregnancy due to potential effects on fetal development and lactation.
How long does it take to see results?
Many users report symptom relief within a few menstrual cycles, typically 2-3 months of consistent usage.
Can chasteberry be taken with other supplements?
Consult a healthcare provider before combining chasteberry with other supplements, especially those affecting hormone levels.
Does chasteberry increase or decrease lactation?
Chasteberry is not proven to increase lactation and may actually decrease it at high doses.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/31780016/ – This meta-analysis of randomized controlled trials found significant reductions in PMS symptoms for women using chasteberry compared to placebo, with a 2.57 fold increase in symptom remission likelihood.
- https://pubmed.ncbi.nlm.nih.gov/23136064/?adb_sid=7ae2f98c-ecbf-43a0-9dd7-41c1396d29b3 – A systematic review of 13 randomized controlled trials established the efficacy of chasteberry in treating PMS and premenstrual dysphoric disorder with a favorable safety profile.
- https://www.mskcc.org/cancer-care/integrative-medicine/herbs/chasteberry – Memorial Sloan Kettering reports on chasteberry highlighting its applications in treating reproductive disorders, noting a need for more rigorous studies to substantiate its benefits.
- https://www.ncbi.nlm.nih.gov/sites/books/NBK501807/ – This source discusses the pharmacology and therapeutic uses of chasteberry, accentuating its hormonal influence and noting potential side effects.
- https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0032-1327831.pdf – This review article outlines empirical evidence on chasteberry's mechanisms and potential effects on female reproductive health, emphasizing its impact on hormonal pathways.
