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Certified Organic Licorice Extract

Also known as: Licorice root, Licorice extract, Glycyrrhiza inflata, Glycyrrhiza uralensis, Glycyrrhiza glabra

Overview

Licorice root, derived from the roots of the licorice plant (*Glycyrrhiza glabra*), has a long history of use in traditional medicine for its therapeutic properties. This herbal supplement is primarily recognized for its anti-inflammatory, antimicrobial, and antioxidant capabilities, making it a suitable candidate for treating diverse health issues such as digestive disorders, respiratory complications, and skin ailments. Key active compounds include glycyrrhizin, flavonoids, and triterpenoids, which contribute to its potential effects. Research on licorice root is moderate, with ongoing studies investigating its various benefits; however, the quality of available evidence is mixed, highlighting the need for further controlled clinical trials to firmly establish its efficacy and safety in specific applications.

Benefits

Licorice root extract has garnered attention for several benefits, including: 1. **Heartburn and Acid Reflux**: It may alleviate symptoms of gastroesophageal reflux disease (GERD), although specific effect sizes are not thoroughly documented. 2. **Gastrointestinal Support**: There is evidence suggesting licorice root can protect and soothe the gastrointestinal lining, indicating potential usage for conditions like leaky gut and stomach ulcers. 3. **Immune Modulation**: The herb possesses antiviral properties, which could bolster immune function. 4. **Respiratory Support**: Licorice root can function as an expectorant and may help relieve sore throat. Overall, licorice root may be particularly beneficial for women, especially concerning menopausal symptom management. However, studies exhibit variability, underscoring the necessity for further research to validate these effects fully.

How it works

Licorice root's biological effects are primarily attributed to its major active constituent, glycyrrhizin, which exerts anti-inflammatory actions by reducing levels of tumor necrosis factor-alpha (TNF-α), matrix metalloproteinases (MMPs), prostaglandin E2 (PGE2), and other free radicals. By modulating these inflammatory mediators, licorice root interacts with multiple body systems, including the digestive, immune, and endocrine systems. Its compounds, including flavonoids, also participate in various cellular processes, enhancing its overall therapeutic potential. The bioavailability of glycyrrhizin is acknowledged, but caution is advised as accumulation may occur with prolonged usage.

Side effects

Licorice root is generally regarded as safe when utilized within recommended dosages; however, chronic use or high doses can lead to adverse effects. Common side effects occurring in more than 5% of users include increased blood pressure, reduced potassium levels, and edema. Rarely, serious electrolyte imbalances may occur at populations with specific risk factors such as pregnancy, hypertension, and existing liver or kidney disease. Individuals on specific medications, including diuretics or anticoagulants, should exercise caution due to potential interactions. Special attention is advised for children and those with underlying health issues, who should only use licorice root under medical supervision.

Dosage

The optimal dosage of licorice root extract remains unclear; however, recommended short-term usage typically falls between 6–18 grams per day. Most supplements provide doses less than 1 gram per serving, but the upper limits for chronic use should be avoided due to possible side effects associated with glycyrrhizin, including hypertension. It is advisable to take licorice root with meals to mitigate gastrointestinal discomfort. Deglycyrrhizinated licorice (DGL) may be a better option for individuals seeking gastrointestinal support without the adverse effects associated with glycyrrhizin. Enhanced bioavailability factors and specific formulations can influence absorption.

FAQs

What should I monitor when taking licorice root?

It's important to monitor your blood pressure and potassium levels, especially with prolonged use.

Is licorice root safe for long-term use?

Long-term use is not advisable without medical supervision due to potential side effects.

When is the best time to take licorice root?

Licorice root is best taken with meals to reduce any gastrointestinal side effects.

How soon can I expect to see results from using licorice root?

Results can vary by condition, and benefits may take several days to manifest.

Can I use licorice root to flavor my foods?

Be cautious; not all flavored products contain actual licorice root; some may only contain anise.

Research Sources

https://draxe.com/nutrition/licorice-root/ – This source provides an overview of licorice root's benefits, potential side effects, and recommended uses, supported by various studies highlighting its anti-inflammatory and gastroprotective properties.
https://pubmed.ncbi.nlm.nih.gov/27650551/ – This PubMed article examines the traditional uses and pharmacological properties of licorice root, with a focus on its active components and their health impacts, revealing significant evidence in gastrointestinal health.
https://www.healthline.com/nutrition/licorice-root – Healthline's article discusses the biochemical impacts of licorice root, emphasizing its historical medicinal roles and the need for careful use due to possible health risks associated with glycyrrhizin.
https://nopren.ucsf.edu/sites/g/files/tkssra5936/f/wysiwyg/ONLY_newarticles_11Feb2022_Food.xlsx – This research outlines various food products with licorice extracts, discussing potential health benefits and risks, although it varies in scientific rigor across studies.
https://www.medicalnewstoday.com/articles/323761 – Medical News Today's article presents comprehensive insights on licorice root's therapeutic properties, potential health advantages, and cautions against overconsumption due to its physiological effects.