Celastrus Extract
Also known as: Celastrus paniculatus, Intellect Tree, Black Oil Plant, Malkangani
Overview
Celastrus paniculatus, commonly known as Intellect Tree or Malkangani, is a plant native to tropical and subtropical regions. It has been traditionally used in Ayurvedic medicine for its purported cognitive-enhancing and neuroprotective properties. The plant contains various bioactive compounds, including sesquiterpene alkaloids and flavonoids, which are believed to contribute to its medicinal effects. While primarily studied in animal models, Celastrus paniculatus is often used to treat various conditions such as muscle cramps, backache, and neurological disorders. Research suggests potential benefits in reducing seizure severity and cognitive deficits, along with antioxidant properties. However, human studies are limited, and more research is needed to confirm its efficacy and safety.
Benefits
Celastrus paniculatus extract has demonstrated potential benefits, primarily observed in animal models. It may reduce seizure severity and cognitive deficits in epilepsy models, suggesting neuroprotective effects. Additionally, it exhibits antioxidant properties, potentially reducing oxidative stress in respiratory inflammation models. Some evidence suggests cognitive benefits and anti-cholinesterase activity, supporting its traditional use for enhancing cognitive function. However, the evidence is preliminary, and human studies are needed to confirm these benefits. Specific effect sizes are not well-documented in human studies, but animal studies show significant reductions in oxidative stress and neuroprotection.
How it works
Celastrus paniculatus is thought to exert its effects through multiple mechanisms. It may act through antioxidant pathways, enhancing levels of glutathione, catalase, and superoxide dismutase, which help to reduce oxidative stress. Additionally, it may modulate dopamine levels and interact with the nervous system, potentially influencing neurotransmitter activity and neuronal protection. While specific molecular targets are not well-defined, it may interact with glutamate receptors and cholinesterase enzymes. However, the exact mechanisms of action, absorption, and bioavailability of Celastrus paniculatus extract in humans are not fully understood and require further investigation.
Side effects
While Celastrus paniculatus is generally considered safe based on traditional use, comprehensive safety data in humans are lacking. Common side effects are not well-documented. Potential uncommon side effects may include gastrointestinal upset or allergic reactions, although these have not been specifically reported. Rare side effects are currently unknown. There is a potential for interactions with antiepileptic drugs or other neuroactive substances, although this is speculative. Due to the lack of safety data, Celastrus paniculatus is contraindicated during pregnancy and breastfeeding. Caution is advised in individuals with neurological conditions or those taking medications for such conditions. Further research is needed to fully assess its safety profile.
Dosage
There is no established minimum effective dose for Celastrus paniculatus in humans. Animal studies have used doses ranging from 250 mg/kg to 500 mg/kg, but human dosing remains speculative. The maximum safe dose has not been determined. There are no specific timing recommendations for its use. Celastrus paniculatus is typically used as a seed extract or oil. Information on absorption factors and required cofactors is currently unavailable. Due to the limited research, it is crucial to consult with a healthcare provider before using Celastrus paniculatus to determine an appropriate and safe dosage.
FAQs
What are the practical usage concerns for Celastrus paniculatus?
Due to the lack of comprehensive safety and efficacy data, users should consult healthcare providers before using Celastrus paniculatus. More modern safety assessments are needed to ensure its safe use.
What results can I expect from taking Celastrus paniculatus?
Potential cognitive benefits and neuroprotection have been observed in animal studies, but human evidence is limited. It is not a proven cognitive enhancer in humans despite traditional claims.
Are there any specific timing or administration guidelines?
No specific guidelines are available for the timing or administration of Celastrus paniculatus. Further research is needed to determine optimal usage protocols.
Is Celastrus paniculatus safe?
While traditionally used, modern safety assessments are needed. Consult with a healthcare provider before use, especially if you have underlying health conditions or are taking medications.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10279989/ – This animal model study investigated the effects of Celastrus paniculatus extract on epilepsy. The study found that the extract reduced seizure severity and cognitive deficits in the animal model, suggesting potential neuroprotective benefits. However, the findings are limited by the lack of human data.
- https://phcog.com/article/sites/default/files/PhcogMag-18-78-400.pdf – This study examined the effects of Celastrus paniculatus on respiratory inflammation in a mice model. The research showed that the extract reduced oxidative stress and neutrophil infiltration, indicating potential anti-inflammatory properties. The study's limitations include its focus on animal models, which necessitates further research to confirm these effects in humans.
- https://fim.cmb.ac.lk/wp-content/uploads/2016/12/Proceedings-Book-2024.pdf – This is a review of traditional medicine practices, including the use of Celastrus paniculatus for various conditions, such as cognitive enhancement. The review highlights the traditional uses but notes the lack of modern clinical trials to validate these claims. The quality of evidence is low due to the reliance on anecdotal data.
- https://www.mdpi.com/1420-3049/26/21/6647 – This study investigates the neuroprotective effects of Celastrus paniculatus. The findings suggest that Celastrus paniculatus has potential in reducing oxidative stress and improving cognitive function. However, further research is needed to confirm these benefits in human trials.
- https://www.science.gov/topicpages/m/medicinal+leeches+genus – This URL is not relevant to Celastrus Paniculatus. It discusses medicinal leeches.