Calcium Undecylenate
Also known as: Calcium salt of undecylenic acid, Calcium Undecylenate
Overview
Calcium Undecylenate is the calcium salt of undecylenic acid, an 11-carbon mono-unsaturated fatty acid synthesized for its antifungal properties. It is primarily utilized as a topical antifungal agent to treat infections caused by dermatophytes and other fungi. The compound is characterized by its broad-spectrum antifungal activity, effectively inhibiting the morphogenesis of Candida albicans and similar fungi. Although significant research supports its antifungal efficacy, most evidence is derived from in vitro studies rather than extensive clinical trials. The product is typically available in creams, ointments, or powders, making it suitable for localized treatment.
Benefits
Calcium Undecylenate demonstrates noteworthy antifungal benefits, successfully inhibiting the growth of various fungi, including dermatophytes, with effective concentrations ranging from 5 to 30 μg/mL at pH 6.0. Its antifungal properties are particularly beneficial for individuals suffering from dermatophyte-related skin infections. Although systematic reviews are lacking, the evidence for its antifungal efficacy is well-documented in laboratory studies. Benefits typically manifest within days to a week of topical application, contingent on the infection's severity.
How it works
Calcium Undecylenate operates by inhibiting the morphogenic shift of fungi from unicellular yeast forms to invasive hyphal forms, critical for their growth and infection capability. This action disrupts fungal cell membrane integrity and interferes with metabolic functions essential for fungal proliferation, achieving its effects locally with minimal systemic absorption when applied to the skin or mucous membranes.
Side effects
Calcium Undecylenate is generally safe for topical use. The most common side effects, occurring in more than 5% of users, include local irritation, such as redness, itching, or a burning sensation at the application site. Uncommon side effects may include allergic reactions or contact dermatitis, occurring in 1-5% of users. Rare side effects are less than 1% and largely undocumented. As it is applied topically and has minimal systemic effect, significant drug interactions are not expected. However, it is contraindicated in individuals with hypersensitivity to undecylenic acid or calcium salts. Caution should be exercised for use in pregnant or breastfeeding women, though limited evidence of harm exists.
Dosage
The minimum effective dose of Calcium Undecylenate for antifungal activity is typically within 5 to 30 μg/mL in topical formulations. The dosage range should be adjusted based on specific formulations and the severity of the condition treated. While there’s no established maximum safe dose, since systemic absorption is minimal, application frequency often ranges from 2-3 times daily, depending on the product and the infection's severity. Topical application on clean affected areas is recommended to maximize efficacy.
FAQs
How often should it be applied?
Typically, it should be applied 2-3 times a day based on the formulation and the severity of the infection.
Can it be used on sensitive skin?
Yes, it is generally safe, but conducting a patch test is recommended to avoid allergic reactions.
How long does it take to see results?
Results are usually seen within a few days to a week after application.
Is it safe for children and pregnant women?
While considered generally safe, caution is advised due to limited evidence in these populations.
How should it be applied for maximized effectiveness?
It should be applied to cleaned affected areas to ensure maximum efficacy.
Research Sources
- https://drugs.ncats.io/drug/77YW1RTU8V – This source provides details on the chemical properties and uses of Calcium Undecylenate, noting its primary application as an antifungal agent with effective concentrations for treating dermatophyte infections.
- https://www.mdpi.com/2072-6643/13/2/368 – The article discusses the antimicrobial activities of undecylenic acid and its calcium salt, highlighting their antifungal efficacy at specified concentrations, contributing valuable evidence to support the use of Calcium Undecylenate.
- https://pubchem.ncbi.nlm.nih.gov/compound/14865 – This database entry provides comprehensive information on Calcium Undecylenate, including its chemical structure, properties, and relevant usage contexts, emphasizing its role in dermatological formulations against fungal infections.
