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Blueactiv Wild Blueberry Extract

Also known as: Vaccinium angustifolium, Wild Blueberry Extract (WBE), Blueactiv Wild Blueberry Extract, Wild Blueberry, American Blueberry, Wild Blueberry Extract

Overview

Wild Blueberry Extract (WBE) is derived from Vaccinium angustifolium, a plant renowned for its substantial anthocyanin content, which provides notable antioxidant properties. Primarily used to enhance cognitive function and support cardiovascular health, WBE is particularly beneficial for older adults aged 68 to 75, who may experience improvements in cognitive tasks and regulation of blood pressure. Available in standardized capsule form, WBE guarantees a consistent output of anthocyanins and polyphenols, facilitating effective supplementation. While preliminary studies show promising results regarding cognitive enhancement and cardiovascular benefits, more extensive long-term research is necessary to establish definitive dosage and efficacy parameters.

Benefits

Research supports several benefits of Wild Blueberry Extract, especially for older populations. A notable dosage of 222 mg is linked to significant improvements in cognitive function, particularly executive functioning and episodic memory, as evidenced by the ROAB study which noted marked performance enhancements post-lunch. WBE also contributes to reductions in both systolic and diastolic blood pressure with statistically significant results (p-value of 0.038). Additionally, the antioxidant properties of anthocyanins positively influence inflammatory responses within the body. While these effects demonstrate strong evidence, they may be subtle, indicating the necessity for further research to fully understand long-term benefits.

How it works

The efficacy of Wild Blueberry Extract is mainly due to its high levels of anthocyanins and polyphenols that activate several biological pathways. These compounds enhance antioxidant defenses, improve endothelial function, and provide neuroprotection, which are crucial for cognitive and cardiovascular health. Specifically, anthocyanins target oxidative stress and inflammation pathways by interacting with key molecular targets, including NF-κB. Although the absorption of these compounds can be relatively low, their metabolism into active forms significantly impacts health outcomes.

Side effects

Wild Blueberry Extract is considered safe when consumed in recommended doses, with studies indicating no major adverse effects, yielding a favorable safety profile. Common side effects remain very low (less than 5% occurrence), with rare effects documented in less than 1% of cases due to limited participant numbers. No major drug interactions have been reported, yet individuals taking medications that affect blood pressure or cognitive function are advised to exercise caution. While no contraindications are established, those with preexisting conditions, as well as pregnant or breastfeeding women, should consult healthcare professionals before starting supplementation.

Dosage

The recommended minimum effective dosage of Wild Blueberry Extract is approximately 222 mg, correlating with findings that indicate benefits to cognitive and cardiovascular health. Higher dosages, up to 888 mg, have been investigated and shown to be well-tolerated. Timing of WBE intake is critical, with advice to take it post-lunch to counteract cognitive decline observed after meals. Predominantly available in capsule form, WBE is standardized to provide at least 35% polyphenols and 5% anthocyanins. The presence of other nutrients may also influence absorption rates.