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Black Cohosh Extract

Q: Is 27-Deoxyactein safe to use?

Generally safe when used appropriately, but it's important to consult a healthcare provider due to potential hepatotoxicity and drug interactions.

Q: When should I take 27-Deoxyactein?

There is no specific timing for administration; however, consistency in taking the supplement is advisable.

Q: What results can I expect from using 27-Deoxyactein?

Improvements in menopausal symptoms may occur, but findings are variable and not all studies report significant benefits.

Q: Does 27-Deoxyactein have estrogenic effects?

No, it does not significantly alter circulating hormone levels and is not considered estrogenic like hormone replacement therapy.

Also known as: Cimicifuga racemosa, black cohosh extract, Actein, 27-Deoxyactein

Overview

27-Deoxyactein is a triterpene glycoside obtained from the rhizome of *Cimicifuga racemosa*, commonly known as black cohosh, which is a herb native to North America. This extract is frequently utilized in dietary supplements aimed primarily at alleviating menopausal symptoms like hot flashes and mood disorders. It also serves as a marker compound, distinguishing *Cimicifuga racemosa* from similar species. Clinical trials have showcased its positive influence on menopausal symptoms; however, results can be inconsistent among studies. Black cohosh extract is usually offered in standardized capsule or tablet forms that facilitate precise dosing of 27-deoxyactein for enhanced therapeutic outcomes.

Benefits

The primary benefit of 27-deoxyactein is its efficacy in alleviating menopausal symptoms, supported by systematic review evidence indicating a significant mean standardized difference of 0.385 in symptom relief (p < 0.0001). Improvement in sleep quality and reduction of psychological disturbances have also been observed, particularly in peri- and postmenopausal women through various observational studies. Despite these reported benefits, the clinical relevance remains subject to debate due to modest effect sizes and variability across findings, underscoring the need for further research to fully understand its impact.

How it works

The precise mechanism of action for 27-deoxyactein is not fully elucidated. It is believed to interact with neurotransmitter systems in the body without functioning as an estrogen, thus avoiding notable modifications in circulating hormone levels. The compound may engage with unidentified molecular targets associated with osteoclastogenesis and potentially influence actions within the central nervous system. Ongoing research is required to clarify its biological pathways and mechanisms.

Side effects

27-Deoxyactein is generally regarded as safe when used according to recommendations, although some may experience common side effects such as gastrointestinal discomfort, headaches, and dizziness in more than 5% of users. Less frequent reactions (1-5%) may include allergic responses and skin rashes. Severe adverse effects, notably hepatotoxicity, are rare (less than 1%) and not definitively linked to the compound. Individuals on medications that affect the liver should exercise caution, while pregnant women and those with liver issues are advised against its use. Furthermore, 27-deoxyactein can interact with blood thinners and other medications; therefore, consultation with a healthcare provider before use is recommended.

Dosage

The suggested dosage of 27-deoxyactein typically falls between 40 mg and 160 mg per day, with evidence indicating that a range of 40 mg to 80 mg may suffice for therapeutic effects. Although no official upper limits have been defined, higher dosages above 160 mg are less frequently investigated. The extract can be ingested at any time, though consistency in daily intake is advisable to optimize results. It is generally available in capsule or tablet presentations designed to ensure proper dosing and facilitate optimal absorption.