ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Back

Bioperine Black Pepper Extract

Also known as: Piperine extract, Black pepper alkaloid complex, BioPerine, Piper nigrum extract

Overview

BioPerine, a patented extract derived from *Piper nigrum* (black pepper), is standardized to contain a minimum of 95% piperine, its primary bioactive alkaloid. It is primarily recognized as a bioavailability enhancer, modulating intestinal membranes to improve the absorption of nutrients and drugs. Research indicates its efficacy in boosting the absorption of various compounds, particularly fat-soluble nutrients. Emerging evidence also suggests potential neuroprotective effects, though further research is needed to confirm these findings in human trials. BioPerine functions as a thermonutrient, influencing thermogenesis within intestinal epithelial cells. It is available in capsule and powder forms and is often included in dietary supplements to enhance nutrient uptake.

Benefits

BioPerine's primary benefit is enhancing nutrient bioavailability. Studies show it significantly increases the absorption of curcumin (by up to 2000%) and improves iron absorption in physically active individuals. The enhanced absorption is particularly notable for fat-soluble compounds like curcumin, resveratrol, and vitamins A, D, E, and K. Emerging research suggests potential neuroprotective effects, with preclinical models demonstrating MAO-B inhibition and blood-brain barrier permeability. Animal models also indicate antioxidant capacity, with reductions in lipid peroxidation. However, more human studies are needed to confirm these secondary effects.

How it works

BioPerine enhances bioavailability through several mechanisms. It stimulates intestinal epithelial thermogenesis via TRPV1 modulation, increasing nutrient transport. It inhibits CYP3A4 and P-gp enzymes, reducing the breakdown and efflux of drugs and nutrients, thereby increasing their bioavailability. Additionally, BioPerine alters the lipid bilayer structure of intestinal cells, enhancing paracellular transport. Its MAO-B inhibition contributes to potential neuroprotective effects by modulating neurotransmitter metabolism. These actions collectively improve the absorption and utilization of co-administered nutrients and drugs.

Side effects

Common side effects of BioPerine include gastrointestinal discomfort, reported in 5-8% of users at doses exceeding 20mg. Uncommon side effects may include hypoglycemia in predisposed individuals. BioPerine can interact with drugs metabolized by CYP3A4 (e.g., cyclosporine, midazolam) and P-gp substrates (e.g., digoxin), potentially increasing their plasma concentrations and effects. It is contraindicated in pregnancy due to insufficient safety data and should be used with caution in individuals with gallbladder disease. Monitoring blood glucose levels is advisable for those prone to hypoglycemia. Exceeding recommended dosages may increase the risk of adverse effects.

Dosage

The minimum effective dose of BioPerine for nutrient absorption is 5mg. The optimal dosage range is 5-20mg taken with meals to enhance nutrient uptake. The maximum safe dose is 20mg per day for acute use and 15mg per day for chronic use. It should be taken concurrently with the target nutrient or drug to maximize its effect. BioPerine's efficacy is enhanced when taken with fat-soluble nutrients. Exceeding the recommended dosage does not necessarily increase absorption and may elevate the risk of side effects.

FAQs

Does it work for all nutrients?

BioPerine is most effective for enhancing the absorption of fat-soluble compounds, such as curcumin, resveratrol, and vitamins A, D, E, and K. Its effects on water-soluble nutrients are less pronounced.

How quickly does it act?

BioPerine's effects are relatively rapid, with peak plasma enhancement typically observed within 1-2 hours after ingestion. This quick action makes it suitable for concurrent administration with target nutrients.

Is it safe long-term?

Studies up to 12 weeks have not reported significant adverse events with BioPerine. However, long-term safety data is limited, and caution is advised with chronic use, particularly at higher doses. Adhering to recommended dosages is crucial.

Can BioPerine cause stomach upset?

Some individuals may experience mild gastrointestinal discomfort, such as stomach upset, especially at doses exceeding 20mg. Starting with a lower dose and taking it with food can help minimize this effect.

Research Sources

  • https://pmc.ncbi.nlm.nih.gov/articles/PMC7353321/ – This randomized controlled trial involving 40 healthy athletes found that 15mg of piperine resulted in a 15% greater increase in hemoglobin levels compared to placebo over an 8-week period. The study suggests that piperine enhances iron absorption, although it was limited by being a single-center trial without a dose-response analysis.
  • https://www.mdpi.com/2076-3417/9/20/4270 – This study investigates the impact of piperine on drug bioavailability, highlighting its role as a bioavailability enhancer. It discusses piperine's mechanisms, including inhibiting drug metabolism enzymes and increasing intestinal permeability, which can significantly improve the absorption and efficacy of various drugs.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC10187688/ – This preclinical review explores the neuroprotective potential of piperine, demonstrating its ability to cross the blood-brain barrier and inhibit MAO-B at 5-10mg/kg doses. While these findings suggest potential benefits for neurological conditions, human efficacy data is still lacking, warranting further research.
  • https://www.verywellhealth.com/everything-you-need-to-know-about-black-pepper-7564549 – This general overview discusses the health benefits of black pepper, including its antioxidant and anti-inflammatory properties. It highlights piperine's role in enhancing nutrient absorption and provides practical information on incorporating black pepper into the diet, though it lacks detailed scientific analysis.
  • https://www.mdpi.com/1420-3049/28/18/6569 – This review examines the antioxidant properties of piperine and its potential health benefits. It discusses piperine's ability to scavenge free radicals and reduce oxidative stress, contributing to its potential role in preventing chronic diseases. The review also highlights the need for further research to fully understand piperine's antioxidant mechanisms and clinical applications.

Supplements Containing Bioperine Black Pepper Extract

Double Strength Plus Bioperine Turmeric Curcumin 1000 mg by Vitamin World
83

Double Strength Plus Bioperine Turmeric Curcumin 1000 mg

Vitamin World

Score: 83/100
Refine by GNC Beyond Raw
58

Refine

GNC Beyond Raw

Score: 58/100
Complete Cardio Heart & Cholesterol Health by Irwin Naturals
75

Complete Cardio Heart & Cholesterol Health

Irwin Naturals

Score: 75/100
Methylburn Extreme by MuscleMeds
73

Methylburn Extreme

MuscleMeds

Score: 73/100
Thermo Burst Hardcore by GNC Pro Performance
53

Thermo Burst Hardcore

GNC Pro Performance

Score: 53/100
Thermo Igniter 12X by GNC Pro Performance AMP Advanced Muscle Performance
70

Thermo Igniter 12X

GNC Pro Performance AMP Advanced Muscle Performance

Score: 70/100
Thermo Igniter 12X by GNC Pro Performance AMP Advanced Muscle Performance
73

Thermo Igniter 12X

GNC Pro Performance AMP Advanced Muscle Performance

Score: 73/100

Recommended Articles

Boosting Turmeric Absorption: Piperine & Dosages

Boosting Turmeric Absorption: Piperine & Dosages

Piperine can increase turmeric's bioavailability by 2000%, with effective dosages ranging from 500 to 2000 mg of curcumin daily.

Curcumin's Impact on Osteoarthritis Pain

Curcumin's Impact on Osteoarthritis Pain

Curcumin significantly reduces osteoarthritis pain through anti-inflammatory effects with minimal side effects.

Curcumin's Impact on Inflammation: 2024-2025 Insights

Curcumin's Impact on Inflammation: 2024-2025 Insights

Recent meta-analyses confirm curcumin supplements significantly reduce inflammation, offering a potential supplementary treatment for chronic conditions.

Curcumin vs. NSAIDs: Pain Management Effectiveness

Curcumin vs. NSAIDs: Pain Management Effectiveness

Clinical trials show curcumin is an effective, safer alternative to NSAIDs for pain management, with fewer side effects.