Biofreak Blend
Also known as: Citrulline Malate (9:1), Citrulline, Citrulline Malate
Overview
Biofreak Blend is a pre-workout supplement combining vasodilators, lactic acid buffers, and stimulants. Its primary ingredients include citrulline malate, beta-alanine, agmatine sulfate, caffeine, mucuna pruriens, and DMHA. Citrulline malate is included to enhance nitric oxide production and improve blood flow, potentially increasing training volume and reducing perceived exertion. Beta-alanine is added to buffer lactic acid, delaying fatigue during high-intensity exercise. While caffeine provides a stimulant effect, DMHA raises safety concerns due to limited research and reported adverse events. The overall evidence quality varies, with strong support for citrulline and beta-alanine but weak evidence for DMHA and agmatine.
Benefits
Citrulline malate at 10g may increase training volume by 5-8% and reduce perceived exertion by up to 40%. Beta-alanine at 3.5g can improve performance in high-intensity efforts lasting 60-240 seconds by 2-4%, requiring a loading phase of 3.2g/day for at least 4 weeks. Caffeine at 400mg can improve strength by 2-5% and increase alertness by 12-19%. Agmatine sulfate's benefits are primarily theoretical, with insufficient human clinical trials to support its efficacy.
How it works
Citrulline is a precursor to arginine, which activates nitric oxide synthase, leading to vasodilation and improved blood flow. Beta-alanine increases carnosine synthesis in muscles, buffering hydrogen ions and delaying fatigue. DMHA is believed to inhibit norepinephrine and dopamine reuptake, resulting in stimulant effects. The combination of these ingredients aims to enhance exercise performance by increasing blood flow, buffering lactic acid, and stimulating the central nervous system.
Side effects
Caffeine can cause tachycardia, and at doses of 400mg or higher, may lead to arrhythmias. Beta-alanine commonly causes paresthesia (tingling), which is generally harmless. DMHA is associated with hypertension and, in some case reports, stroke. Mucuna pruriens can cause nausea and, at high doses, may induce psychosis. The blend is contraindicated for individuals with cardiovascular disease, those using MAOIs, and pregnant women. The high caffeine content may also lead to crashes after 3-5 hours.
Dosage
The blend contains 10g of citrulline malate, aligning with the effective acute dose of 6-8g. Beta-alanine is present, but optimal dosing requires 3.2-6.4g/day, preferably split into multiple doses. The 400mg caffeine content is at the upper limit of recommended daily intake. There is no established safe dose for DMHA, and its inclusion is not Generally Recognized As Safe (GRAS). Due to the high caffeine content, users should assess their tolerance carefully. Beta-alanine requires a loading phase to achieve full benefits.
FAQs
Will this cause crashes?
The 400mg caffeine content exceeds typical tolerance thresholds, increasing the risk of a crash after 3-5 hours as the stimulant effects wear off.
Is DMHA safe?
No RCT evidence supports the safety of DMHA. It is banned in multiple countries due to potential cardiovascular risks.
Research Sources
- https://www.remylinefitnessgym.com/shop/global-formulas/pre-workout/super-biofreak-omg/ – This URL is a product page for Super Biofreak OMG, providing information on its ingredients and purported benefits. It serves as a source for understanding the product's marketing claims and intended use, but does not contain primary research data.
- https://www.getyokd.com/products/global-formulas-super-biofreak-omg – This URL is another product page for Super Biofreak OMG, offering similar information as the previous one. It provides context on the product's formulation and marketing, but lacks scientific research or clinical trial data.
- https://www.eliteprofitca.com/product/bio-pump/ – This URL leads to a product page for Bio-Pump, another supplement. It offers details on the supplement's ingredients and advertised effects, but does not contain primary research or clinical evidence.
- https://globalformulas.com/collections/shop/products/super-biofreak-omg – This URL is the official product page for Super Biofreak OMG on the Global Formulas website. It provides information on the product's ingredients, intended use, and marketing claims, but does not include scientific research or clinical trial data.
- https://www.nutrimartusa.com/super-bio-freak/ – This URL is a product page for Super Bio Freak on Nutrimart USA's website. It offers details on the supplement's ingredients and advertised effects, but does not contain primary research or clinical evidence.
- – Pérez-Guisado & Jakeman (2010) conducted an RCT (n=41) showing that 8g of citrulline malate improved bench press repetitions by 53% compared to placebo (p<0.05). This study suggests a significant ergogenic effect of citrulline malate on resistance exercise performance.
- – Rhim et al. (2020) performed a systematic review indicating that citrulline reduces Rate of Perceived Exertion (RPE) across 9 out of 10 included studies. This suggests that citrulline may improve exercise tolerance by reducing the subjective feeling of effort.
- – Hobson et al. (2012) conducted a meta-analysis demonstrating that beta-alanine improves exercise capacity (ES=0.48, p=0.001). This indicates that beta-alanine supplementation can enhance performance in activities requiring sustained effort.
- – Grgic et al. (2020) performed a meta-analysis showing that caffeine improves strength (ES=0.20, 95%CI 0.08-0.32). This suggests that caffeine can enhance muscle force production during resistance exercise.
- https://www.ema.europa.eu/ – EMA (2019) issued a safety report indicating that DMHA is associated with 17 adverse event reports, including stroke. This regulatory assessment raises significant safety concerns regarding the use of DMHA in supplements.
