Bifidobacterium lactis HRVSD524
Also known as: Bifidobacterium lactis HRVSD524, B. lactis HRVSD524, Bifidobacterium animalis subspecies lactis HRVSD524
Overview
Bifidobacterium animalis subspecies lactis HRVSD524 is a specific strain of beneficial bacteria belonging to the Bifidobacterium genus, commonly found in the human gastrointestinal tract and fermented dairy products. As a probiotic supplement, its primary application is to support digestive health and alleviate common gastrointestinal symptoms. This strain is particularly noted for its ability to improve bowel movement frequency and consistency, making it a valuable intervention for constipation. B. lactis strains, including HRVSD524, are characterized by their resilience, capable of surviving the harsh acidic environment of the stomach and bile salts in the small intestine, allowing them to transiently colonize the gut. Once in the gut, they interact beneficially with the host microbiome, contributing to a balanced gut environment. Research on B. animalis subspecies lactis strains, while not always specific to HRVSD524, indicates a moderate to advanced level of scientific inquiry, with multiple randomized controlled trials and systematic reviews supporting their efficacy in managing gastrointestinal issues and potentially influencing lipid metabolism and immune modulation.
Benefits
Bifidobacterium animalis subspecies lactis HRVSD524 offers several evidence-based benefits, primarily centered on improving gastrointestinal health. A systematic review and meta-analysis from 2022 demonstrated that supplementation with B. animalis subspecies lactis significantly improved gastrointestinal symptoms such as abdominal pain and bowel movement frequency in adults, with statistically significant therapeutic effects (p < 0.05). This indicates a strong level of evidence for its efficacy in alleviating common digestive discomforts. Beyond these primary effects, studies suggest that B. lactis strains can improve stool consistency, reduce flatulence, and favorably modulate gut microbiota composition. There is also some evidence pointing to beneficial effects on blood lipid profiles, possibly through the modulation of bile acid metabolism. These benefits have been observed across various populations, including adults with general gastrointestinal complaints, women experiencing constipation, and in some clinical contexts, infants and children. The effect sizes for symptom relief, such as increased stool frequency and reduced abdominal discomfort, are considered moderate but clinically relevant, with improvements typically observed within 2 to 4 weeks of consistent supplementation.
How it works
Bifidobacterium animalis subspecies lactis HRVSD524 exerts its beneficial effects primarily through modulating the intestinal microbiota. It contributes to a healthier gut environment by increasing the population of beneficial bacteria. This probiotic strain also plays a role in enhancing gut barrier function, which is crucial for preventing the translocation of harmful substances from the gut into the bloodstream. Furthermore, it interacts with host immune responses, potentially contributing to a balanced immune system. Within the gastrointestinal tract, B. lactis HRVSD524 influences stool characteristics, leading to improved bowel movement frequency and consistency. While specific molecular targets for HRVSD524 are still being elucidated, related B. lactis strains are known to deconjugate bile salts and produce short-chain fatty acids (SCFAs). SCFAs are vital for gut health, providing energy to colonocytes and influencing various physiological processes. As a probiotic, it acts locally within the gut lumen and is not absorbed systemically; its efficacy relies on its ability to survive the acidic conditions of the stomach and transiently colonize the intestine.
Side effects
Bifidobacterium animalis subspecies lactis HRVSD524 is generally recognized as safe (GRAS) and possesses a strong safety record, supported by extensive clinical use and trials. The most common side effects, occurring in more than 5% of users, are mild gastrointestinal symptoms such as bloating or gas. These symptoms are typically transient and tend to resolve as the body adjusts to the supplement. Uncommon side effects, reported in 1-5% of individuals, are not significantly documented in high-quality studies. Similarly, rare side effects, occurring in less than 1% of users, including serious adverse events, have not been linked to B. lactis supplementation. There are no known significant drug interactions associated with B. lactis HRVSD524. However, caution is advised for severely immunocompromised individuals due to a theoretical, albeit rare, risk of infection. Despite this, the strain has a documented safe use profile across various populations, including infants, children, and adults, though specific clinical guidance should always be followed for vulnerable groups.
Dosage
The effective dosage for Bifidobacterium animalis subspecies lactis HRVSD524, as observed in clinical studies, typically ranges from 10^9 to 10^10 colony-forming units (CFU) per day. An optimal dosage range commonly cited in clinical trials that demonstrate benefit is between 1 and 10 billion CFU daily. There is no established maximum safe dose, with doses up to 10^10 CFU/day generally well-tolerated without adverse effects. This probiotic can be administered daily, either with or without food, as the timing of intake does not appear to critically impact its efficacy. B. lactis HRVSD524 is available in various forms, including capsules, powders, and incorporated into fermented dairy products. The survival of the probiotic through gastric acid is strain-dependent, and some formulations may include protective coatings to enhance viability. While not strictly required, B. lactis HRVSD524 is sometimes combined with prebiotics, such as polydextrose, to further enhance its efficacy and support the growth of beneficial gut bacteria.
FAQs
Is B. lactis HRVSD524 effective for constipation?
Yes, evidence supports that B. lactis HRVSD524 can improve bowel movement frequency and stool consistency, making it effective for managing constipation.
Are there any safety concerns?
B. lactis HRVSD524 is generally considered safe for most individuals, with minimal and typically transient side effects like mild bloating or gas.
How long before benefits appear?
Improvements in bowel function and symptoms are typically observed within 2 to 4 weeks of consistent daily supplementation.
Can it be used with antibiotics?
Yes, probiotics like B. lactis HRVSD524 can be used alongside antibiotics, but it's advisable to take them at different times to maximize probiotic survival.
Does it permanently colonize the gut?
No, colonization by B. lactis HRVSD524 is transient; continuous supplementation is necessary to maintain its beneficial effects in the gut.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/34918142/ – This systematic review and meta-analysis by Araújo et al. (2022) investigated the effects of Bifidobacterium animalis subspecies lactis supplementation on gastrointestinal symptoms. The study found that B. animalis subspecies lactis significantly improved GI symptoms, including abdominal pain and bowel function, in adults across multiple randomized controlled trials, demonstrating a consistent and statistically significant therapeutic effect.
- https://www.mdpi.com/2076-2607/11/10/2501 – This narrative review from 2023 summarized clinical evidence regarding B. lactis in infants and children. It concluded that B. lactis strains are generally safe and show potential benefits in pediatric populations, although it highlighted the need for more specific randomized controlled trials to solidify findings for particular strains like HRVSD524.
- https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00124/full – This systematic review from 2018 emphasized that probiotic efficacy is highly strain- and disease-specific. It included meta-analyses that showed B. animalis subspecies lactis strains are beneficial in various gastrointestinal conditions, underscoring the importance of selecting the right strain for specific health outcomes, though data on HRVSD524 specifically was limited.
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.790561/full – This narrative review from 2021, which included data from RCTs, focused on the effects of B. lactis strains, including HN019. It reported that B. lactis strains improve bowel movement frequency and stool consistency, and may also modulate lipid metabolism, with observed benefits typically within 2-4 weeks of supplementation, despite some studies having small sample sizes.
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