Bifidobacterium Breve Br03 Dsm 16604
Also known as: *B. breve* BR03, *Bifidobacterium breve*, *Bifidobacterium breve* BR03 (DSM 16604)
Overview
*Bifidobacterium breve* BR03 (DSM 16604) is a probiotic strain associated with gut health and immune system support. This strain is a member of the natural human gut microbiota, playing crucial roles in enhancing immune responses, improving gut flora balance, and contributing to metabolic health. Key characteristics include its capacity to induce cytokine production and its role in modulating the gut microbiome. Although research on *B. breve* BR03 is moderately developed, several randomized controlled trials have shown promising efficacy, especially in pediatric populations. Typically found in dietary supplements, it is available in various forms such as capsules and powders, with a focus on their probiotic properties for digestive health.
Benefits
*Bifidobacterium breve* BR03 exhibits several evidence-backed benefits. It has demonstrated a reduction in pro-inflammatory cytokines, specifically TNF-α levels, particularly in celiac patients, which may enhance gut health. Additionally, this strain has been shown to improve insulin sensitivity in obese children. It also holds potential for preventing functional gastrointestinal disorders in newborns. Beneficial effects are primarily noted in pediatric populations suffering from celiac disease and obesity, with significant clinical findings indicating notable reductions in inflammation and improved metabolic profiles. Evidence suggests that these benefits may manifest within a few months of consistent supplementation.
How it works
The mechanism of action of *Bifidobacterium breve* BR03 involves modulating the immune system by inducing cytokine production, notably IL-10, which plays a key role in reducing inflammation. This strain enhances the gut microbiota composition, promoting beneficial bacterial populations, thereby contributing to improved metabolic health and immune function. The strain interacts with both the innate and adaptive immune systems, influencing key cytokine production pathways critical to maintaining gut health and systemic inflammation.
Side effects
*Bifidobacterium breve* BR03 is generally regarded as safe, with minimal side effects reported in clinical trials. Commonly, no adverse effects have been consistently documented; however, some individuals may experience mild gastrointestinal discomfort, though this is rare. There are no significant drug interactions recorded, and no contraindications are established, although caution is advised for immunocompromised individuals. The strain appears to be safe for pediatric use based on supportive study findings. Continuous monitoring is encouraged for any unusual reactions.
Dosage
The recommended dosage for *Bifidobacterium breve* BR03 typically ranges from 10^8 to 10^9 CFU per day, with most studies suggesting an effective minimum dose of approximately 10^9 CFU. Higher doses up to 10^9 CFU are commonly used without notable adverse effects. For optimal efficacy, these probiotics are best taken with food, enhancing their survival through the gastrointestinal tract. Available in capsules or powder form, ensuring appropriate storage in a cool, dry environment is crucial for maintaining the viability of the probiotic strains.
FAQs
How should I store *Bifidobacterium breve* BR03?
Store in a cool, dry place to maintain the viability of the probiotic strains.
Is *Bifidobacterium breve* BR03 safe for everyone?
Generally safe for most individuals; consult a healthcare provider if immunocompromised.
When is the best time to take this probiotic?
It is best taken with meals to enhance its survival through the stomach.
How long does it take to see results?
Benefits may take several weeks to become noticeable, depending on individual health conditions.
Can *Bifidobacterium breve* BR03 cure any diseases?
It is not a cure but can support digestive health and immune function.
Research Sources
- https://www.scielo.br/j/rpp/a/cPFZrdv7V3bPXFZY34H9KVG/?format=html&lang=en – This study evaluates the immunomodulatory and functional properties of *Bifidobacterium breve* BR03, illustrating its potential benefits in reducing inflammation in clinical populations.
- https://pubmed.ncbi.nlm.nih.gov/15491374/ – The article discusses various efficacy studies of *Bifidobacterium breve*, underscoring its role in improving gut health and metabolic profiles.
- https://www.longdom.org/open-access/a-systematic-evaluation-of-the-immunomodulatory-and-functional-properties-of-probiotic-embifidobacterium-breveem-br03-dsm-16604-em-44938.html – This systematic review outlines the immunomodulatory effects of *B. breve* BR03, highlighting its synthesis of beneficial cytokines and impact on immune health.
- https://pubmed.ncbi.nlm.nih.gov/34229263/ – The research provides evidence supporting the efficacy of *B. breve* BR03 in increasing insulin sensitivity in youth with obesity.
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2018.00039/full – The article presents an overview of the clinical significance of *Bifidobacterium breve*, focusing on its role in gut health and immunological responses.
Supplements Containing Bifidobacterium Breve Br03 Dsm 16604
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