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Bifidobacterium breve

Also known as: Bifidobacterium breve, B. breve

Overview

Bifidobacterium breve is a species of bacteria naturally residing in the human gut microbiota and is commonly utilized as a probiotic supplement. It is recognized for its potential health benefits, which include the improvement of gut health and the support of the immune system. B. breve is particularly notable for its application in pediatric and preterm infant care, as well as its potential effects on cognitive function and neurodegenerative diseases. This probiotic acts by modulating the gut microbiota, enhancing the gut barrier function, and influencing the immune system. It may also interact with the brain-gut axis, potentially affecting cognitive functions. It is available in various forms, including capsules and powders. While generally considered safe, mild gastrointestinal symptoms such as bloating or gas may occur in some individuals. The research maturity level for B. breve is moderate, with a growing body of evidence supporting its use in various health conditions.

Benefits

Bifidobacterium breve has shown potential in improving cognitive function, particularly in individuals with mild cognitive impairment (MCI). Studies indicate that consuming B. breve MCC1274 over a period of 24 weeks may help suppress brain atrophy progression. Additionally, B. breve is used in preterm infants to support gut health. Emerging evidence suggests that Bifidobacterium strains, including B. breve, may have beneficial effects on neurodegenerative diseases like Alzheimer's and Parkinson's, although more research is needed to confirm these effects. The clinical significance of B. breve varies depending on the condition being treated, with moderate effect sizes observed in cognitive function studies. Benefits from supplementation can be observed within several weeks to months, depending on the condition.

How it works

Bifidobacterium breve primarily functions by modulating the gut microbiota, enhancing the gut barrier function, and influencing the immune system. It interacts with the gastrointestinal and immune systems and may also influence the central nervous system through the gut-brain axis. While specific molecular targets are not well-defined, B. breve produces metabolites that can influence host health. As a probiotic, B. breve colonizes the gut, where it exerts its effects, rather than being absorbed in the traditional sense. This colonization helps to balance the gut flora, promoting a healthier digestive environment and potentially impacting overall well-being.

Side effects

Bifidobacterium breve is generally considered safe for use in healthy individuals and preterm infants. Common side effects may include mild gastrointestinal symptoms such as bloating or gas. Uncommon side effects are not well-documented, but probiotics can occasionally cause allergic reactions or interact with medications. Rare side effects may include infections in immunocompromised individuals. Potential drug interactions may occur with immunosuppressive drugs or antibiotics. It is generally contraindicated in severely immunocompromised individuals. Preterm infants and individuals with compromised immune systems require careful monitoring. While generally safe, it's important to consult with a healthcare provider before starting supplementation, especially for those with underlying health conditions or who are taking medications.

Dosage

While a minimum effective dose is not well-established, typical probiotic doses range from 1 to 10 billion CFU (colony-forming units) per day. The optimal dose for B. breve is not clearly defined and may vary based on the specific health condition being addressed. Generally, doses up to 10 billion CFU per day are considered safe. It is best taken with food to enhance survival through the stomach. B. breve is available in various forms, including capsules and powders. As B. breve colonizes the gut rather than being absorbed, absorption factors are not applicable. No specific cofactors are identified as required for its function.

FAQs

What are the key practical usage concerns for Bifidobacterium breve?

Ensure proper storage and handling to maintain viability. It's also important to source from reputable manufacturers to ensure product quality and accurate CFU counts.

Is Bifidobacterium breve safe for everyone?

Generally safe, but consult a healthcare provider if immunocompromised or if you have underlying health conditions. Monitor for any adverse effects when starting supplementation.

When is the best time to take Bifidobacterium breve?

It is best taken with meals to enhance survival through the stomach. Consistent daily intake is generally recommended for optimal results.

What kind of results can I expect from taking Bifidobacterium breve?

Results vary depending on the condition being treated. Some may experience improved digestive health, while others may see cognitive benefits. It's not a cure-all, and benefits are condition-specific.

Is Bifidobacterium breve a cure-all for all health issues?

No, it is not a cure-all. Benefits are condition-specific, and it should be used as part of a comprehensive health plan, not as a standalone treatment.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/28796951/ – This study highlights the strain-specific benefits of Bifidobacterium breve M-16V when used as a probiotic in preterm infants. The research emphasizes the importance of considering strain-specific data in clinical practice, as different strains can have varying effects on health outcomes. The findings contribute to the understanding of how specific probiotic strains can support gut health in vulnerable populations.
https://www.mdpi.com/2072-6643/17/3/391 – This review explores the potential of Bifidobacterium strains, including B. breve, in influencing neurodegenerative diseases like Alzheimer's and Parkinson's. It suggests that these probiotics may offer beneficial effects, possibly through modulation of the gut-brain axis. However, the review also notes that more robust studies are required to confirm these effects and elucidate the underlying mechanisms.
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1463848/full – This research article likely discusses the effects of B. breve on psychiatric conditions. Further review of the full article is needed to provide a more detailed summary, but it potentially explores the gut-brain axis and the role of probiotics in mental health.
https://journals.sagepub.com/doi/abs/10.3233/JAD-220148?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed – This study investigates the effects of B. breve MCC1274 on individuals with mild cognitive impairment over 24 weeks. The findings suggest that B. breve may help suppress brain atrophy progression, indicating potential cognitive benefits. However, further research is needed to confirm these effects and determine the long-term clinical significance.
https://www.mdpi.com/2072-6643/10/11/1723 – This paper likely discusses the broader applications of probiotics, including B. breve, in various health contexts. A more detailed summary would require reviewing the full article to understand the specific focus and findings related to B. breve and its potential benefits.