Bergamot Polyphenolic Fraction Gold
Also known as: Bergamot Polyphenolic Fraction Gold, BPF Gold, Bergamet Sport, Bergamot Polyphenolic Fraction
Overview
Bergamot Polyphenolic Fraction (BPF) is an extract derived from the juice of bergamot oranges (*Citrus aurantium bergamia*), renowned for its high flavonoid and polyphenolic content. The primary uses of BPF include potential cardiovascular benefits, antioxidant effects, and improvements in metabolic health. Notably, BPF exhibits vaso-protective and anti-inflammatory properties, positioning it as a supplement of interest for health enhancement. Research on BPF is moderate in maturity with several clinical trials available; however, there remains a significant need for systematic reviews to validate findings thoroughly. The evidence quality ranges from well-designed randomized controlled trials (RCTs) to studies requiring further exploration into their methodologies.
Benefits
BPF supplementation demonstrates promising benefits, particularly in improving endothelial function through increased nitric oxide (NO) levels and reduction of asymmetric dimethylarginine (ADMA) levels in athletes. Furthermore, it is associated with amelioration of liver fat content in individuals suffering from non-alcoholic fatty liver disease (NAFLD). Athletes may also experience enhanced maximal oxygen uptake (V_O2max) attributed to BPF usage. Secondary benefits may include improvements in metabolic balance and lipid profiles. Evidence indicates significant outcomes, such as enhanced NO levels and liver fat reduction, observed within a supplementation duration of 4-12 weeks, although comprehensive effect sizes are still needed.
How it works
BPF primarily enhances vascular endothelial function through the promotion of nitric oxide production and the mitigation of oxidative stress. This mechanism facilitates better blood vessel functionality. Moreover, BPF may positively influence hepatic function by alleviating fat accumulation in the liver, implicating its role in lipid metabolism and cardiovascular health. While specific molecular targets are not fully elucidated, BPF appears to interact with enzymes integral to NO synthesis and lipid metabolism pathways.
Side effects
BPF is generally regarded as safe, with minimal side effects reported in clinical investigations. Common side effects, while less than 5%, may include gastrointestinal disturbances such as diarrhea. There's a lack of thorough documentation on rare adverse effects, with no significant occurrences reported. Users should be mindful of potential interactions with medications influencing blood pressure or lipid profiles. There are no standard contraindications; however, caution is recommended in patients with severe cardiovascular conditions, and pregnant or breastfeeding women should seek medical advice due to insufficient data on safety.
Dosage
The minimum effective dose for BPF is typically around 650 mg taken twice daily for cardiovascular benefits. Optimal dosing ranges from 650 mg to 1,500 mg per day, depending on targeted health outcomes. Although the maximum safe dose is not well-defined, doses up to 1,500 mg have been utilized in studies without notable adverse effects. For best absorption, it is advisable to take BPF with meals. Capsules are a common form utilized, and individual factors may impact absorption dynamics.
FAQs
Is BPF safe to use?
BPF is generally considered safe; however, individuals with underlying health conditions should use it under medical supervision.
How should BPF be taken?
It is recommended to take BPF with meals to enhance its absorption.
What results can I expect from BPF?
Users may observe improvements in cardiovascular health and metabolic markers within weeks of supplementation.
Is BPF a substitute for medical treatment?
No, BPF is a complementary supplement and should not replace prescribed medical treatments.
Can BPF interact with medications?
Yes, while generally safe, BPF may interact with medications that affect blood pressure or lipid metabolism.
Research Sources
- https://www.sportsmedoa.com/articles/jsmt-aid1027.php – This study reported that BPF Gold supplementation enhanced endothelial function and increased nitric oxide levels in athletes, highlighting the potential of BPF to improve cardiovascular health metrics.
- https://journals.indexcopernicus.com/api/file/viewByFileId/247802 – A clinical trial indicated that BPF combined with wild cardoon extract significantly reduced liver fat content in patients with NAFLD, although this combination complicates isolating the specific effects of BPF.
- https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00494/full – Research evaluated the metabolic impact of BPF, with findings suggesting reductions in serum cholesterol and triglycerides, providing supportive evidence for its use in managing hyperlipidemia.
- https://www.scirp.org/journal/paperinformation?paperid=44411 – This study validated the antioxidant properties of BPF but noted limitations in study design regarding thorough assessment of its effects.
- https://www.mdpi.com/2077-0472/13/2/249 – A synthesis of various studies on BPF that discussed its health benefits, particularly in cardiovascular and metabolic health, while emphasizing the need for more rigorous research.
