Bergamonte Citrus Bergamot Polyphenolic Extract
Also known as: Bergamot, Bergamot Orange, Citrus bergamot, Bergamonte, Citrus bergamia
Overview
Bergamot (*Citrus bergamia*) is a citrus fruit cultivated mainly in southern Italy, prized for its rich polyphenolic compounds, particularly flavonoids such as neohesperidin and naringin. The fruit and its extracts are commonly used in dietary supplements targeting metabolic health issues like hyperlipidemia and type 2 diabetes. Research supports bergamot's potential to lower cholesterol and regulate blood glucose through its antioxidant and anti-inflammatory properties. However, further large-scale studies are necessary to validate efficacy across diverse demographics. Available supplement forms include liquid extracts, capsules, and powders, with certain formulations engineered to improve bioavailability, enhancing their therapeutic potential.
Benefits
Bergamot polyphenolic extract has demonstrated multiple evidence-based benefits, particularly in lipid management. Clinical studies report significant reductions in total cholesterol (avg. -23.4 mg/dL) and LDL cholesterol (avg. -15.6 mg/dL), along with a modest increase in HDL cholesterol (+4.3 mg/dL). The extract has also proven effective in lowering fasting plasma glucose levels in patients with type 2 diabetes, with statistically significant improvements compared to placebo. Anti-inflammatory and antioxidant properties make it beneficial for conditions such as inflammatory bowel disease. Populations affected by hyperlipidemia or type 2 diabetes exhibit the most significant metabolic improvements, often noted as early as 12 weeks of supplementation.
How it works
Bergamot polyphenols primarily function by modulating critical biological pathways linked to lipid metabolism and inflammation reduction. They interact with enzymes involved in lipogenesis and beta-oxidation, yielding an improved lipid profile. Additionally, these compounds target pro-inflammatory cytokines that contribute to oxidative stress. Enhanced formulations like the BPF phyto supplement can improve the absorption of active bergamot ingredients, maximizing their effects on metabolism and cardiovascular health.
Side effects
Bergamot supplements are generally well-tolerated and deemed safe when used as directed, with no significant adverse effects reported in clinical studies. However, excessive intake may lead to potential health issues. The literature does not document common adverse effects above 5%, while rare and uncommon reactions have not been observed. It's crucial for individuals on other medications to consult a healthcare professional to avoid possible interactions. Precaution is especially warranted for vulnerable populations, including children, pregnant or nursing women, and older adults, due to a lack of sufficient safety studies in these groups. Overall, while significant safety concerns have not been identified, monitoring individual responses is advisable.
Dosage
The minimum effective dose of bergamot extract is around 150 mg/day, specifically for standardized flavonoid content. Clinical trials have explored dosages reaching up to 1000 mg/day, with noteworthy effects consistently recorded within this range. No established upper limit for safe dosage exists; however, surpassing recommended amounts could lead to adverse effects. Daily supplementation is ideal, preferably taken at consistent intervals throughout the day to ensure adherence. Formulations vary from liquid extracts to capsules, with certain products like BPF phyto supplements demonstrating improved bioavailability. For optimal results, bergamot should be integrated into a balanced diet and healthy lifestyle.
FAQs
Are bergamot supplements safe?
Bergamot supplements are generally safe for most individuals but caution is advised for sensitive populations and those on other medications.
When should I take bergamot supplements?
Daily supplementation is recommended, with consistency in timing for best adherence and effect.
How long until I see results from bergamot?
Significant improvements in blood glucose and lipid profiles can typically be observed within 12 weeks of regular supplementation.
Can I replace my medication with bergamot?
Bergamot supplements should not replace prescribed medications; they can be used as a complementary approach under medical supervision.
Research Sources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610478/ – This meta-analysis reviews the effects of bergamot on dyslipidemia and metabolic syndrome, summarizing findings from multiple studies that collectively indicate significant improvements in lipid profiles with bergamot supplementation.
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407755/ – This clinical trial investigates the effects of bergamot polyphenolic extract on cholesterol levels and reports meaningful decreases in total and LDL cholesterol among participants, particularly those with hyperlipidemia.