Bacillus Subtilis Cu1
Also known as: B. subtilis CU1, LifeinU™ Bacillus subtilis CU1, Bacillus subtilis CU1
Overview
Bacillus subtilis CU1 is a Gram-positive, spore-forming bacterium found in soil and the gastrointestinal tract of animals. It serves as a probiotic supplement, commonly used to enhance immune health, reduce inflammation, and ameliorate gastrointestinal symptoms. Characterized by genomic analyses, this strain exhibits no antibiotic resistance or toxigenic activity. The research surrounding Bacillus subtilis CU1 is moderate to high in maturity, supported by randomized controlled trials and safety assessments indicating its potential efficacy and safety for human consumption, particularly in elderly populations.
Benefits
Evidence suggests Bacillus subtilis CU1 facilitates immune modulation by increasing activation markers on immune cells and enhancing phagocytosis, leading to elevated levels of pro-inflammatory cytokines. In elderly populations, it has been linked to a significant reduction in several serum cytokines related to low-grade inflammation. While gastrointestinal benefits specific to CU1 are less documented, related strains have shown potential in alleviating symptoms such as constipation, indigestion, and dyspepsia, pointing to a broader applicability for gut health improvement.
How it works
Bacillus subtilis CU1 activates immune cells by increasing the expression of key markers, stimulating pathways that enhance phagocytosis. It modifies cytokine levels, driving an increase in pro-inflammatory cytokines in response to bacterial components, thereby modulating the immune response. As a spore-forming bacterium, it survives the gastrointestinal passage, germinating in the colon to positively influence gut microbiota.
Side effects
Bacillus subtilis CU1 has a commendable safety profile with no significant side effects reported in clinical trials. Common adverse reactions are absent (>5% of participants), and uncommon (1-5%) or rare effects (<1%) are not documented. No significant drug interactions are known, and there are no contraindications identified. Special safety evaluations in healthy elderly subjects indicate that it does not adversely affect liver and kidney function, hematological markers, or vital signs, supporting its safety for use in this demographic.
Dosage
The generally recommended dosage for Bacillus subtilis CU1 is at least 2 × 10^9 colony-forming units (cfu) per day, as indicated by clinical studies. This dosage is deemed optimal for achieving immune benefits and reducing inflammation. The strain is available in spore form, which ensures survival through digestive transit, thus facilitating effective colonization in the gut. There are no established maximum dosage limits; however, consistency in daily intake is advised for consistent effects.
FAQs
Is Bacillus subtilis CU1 safe?
Yes, Bacillus subtilis CU1 is well-tolerated and safe for most individuals, with no significant adverse effects reported.
When should I take Bacillus subtilis CU1?
It can be taken at any time during the day; consistency in daily intake is recommended for best results.
What benefits can I expect?
Users often experience improved immune response, reduced inflammation, and potential alleviation of gastrointestinal discomfort.
Is Bacillus subtilis CU1 a cure for my gut issues?
While it can help support gut health, it should not be viewed as a cure-all for gastrointestinal problems.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/39151920/ – This randomized controlled trial involving 88 participants demonstrated that Bacillus subtilis CU1 significantly enhanced immune cell activation and reduced low-grade inflammation in elderly subjects over a four-week period.
- https://pubmed.ncbi.nlm.nih.gov/27825987/ – A safety assessment showed that Bacillus subtilis CU1 was safe and well-tolerated among healthy elderly participants over a 16-week study, with no adverse physiological effects reported.
- https://www.mdpi.com/2072-6643/15/21/4490 – This study utilized a different strain, BG01-4™, demonstrating significant improvements in gastrointestinal symptoms of constipation, indigestion, and dyspepsia, which are relevant for understanding the broader effects of Bacillus subtilis.
Supplements Containing Bacillus Subtilis Cu1
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