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Astragalus Extract Concentrate

Also known as: Astragalus membranaceus, Huang Qi, Milk Vetch, Astragalus Extract, Astragalus Extract Concentrate

Overview

Astragalus Extract Concentrate is derived from the root of Astragalus membranaceus, a plant widely used in Traditional Chinese Medicine. It is valued for its potential immunomodulatory and cardioprotective properties. The extract contains bioactive compounds like astragalosides (especially astragaloside IV), polysaccharides, and flavonoids, which contribute to its pharmacological effects. Primarily, it's used as an adjunct in cancer therapy to improve tumor response rates, for cardiovascular health, in the treatment of viral myocarditis, and to reduce fatigue, particularly cancer-related fatigue. Research includes multiple randomized controlled trials (RCTs) and meta-analyses, especially in oncology and cardiovascular contexts. Evidence includes systematic reviews and meta-analyses with some high-quality RCTs, though variability in study quality and heterogeneity in formulations exist. It is available in various forms, including oral capsules, tablets, decoctions, and injections.

Benefits

Astragalus Extract Concentrate has shown promise in several areas. As a cancer therapy adjunct, a meta-analysis indicated that Astragalus-containing herbal formulas combined with chemotherapy significantly improved tumor response rate compared to chemotherapy alone. In cardiovascular health, studies have demonstrated that Astragalus membranaceus can reduce serum myocardial enzymes and cardiac troponin I levels, improving clinical treatment efficiency in viral myocarditis patients. Preclinical models suggest astragaloside IV, a key component, can reduce myocardial infarct size and improve left ventricular ejection fraction. Additionally, a novel Astragalus-based extract has been shown to promote bone growth through IGF-1 upregulation, suggesting potential anabolic effects. Preliminary data also suggests it may improve cancer-related fatigue, though more comprehensive results are pending. These benefits have been primarily documented in cancer patients undergoing chemotherapy, patients with viral myocarditis, and potentially in populations with bone growth deficits or cancer-related fatigue.

How it works

Astragalus Extract Concentrate exerts its effects through several biological pathways. It acts as an immunomodulator, enhancing host defense and potentially improving chemotherapy efficacy. In the cardiovascular system, it exhibits cardioprotective effects via antioxidant and anti-inflammatory mechanisms, reducing myocardial injury markers. Furthermore, it promotes growth factors such as IGF-1, contributing to tissue repair and bone growth. Astragaloside IV, a key component, modulates oxidative stress pathways, inflammatory cytokines, and myocardial cell apoptosis. While astragalosides have moderate oral bioavailability, formulations and extraction methods can influence systemic exposure. The extract interacts with the immune system, cardiovascular system, and possibly endocrine pathways related to growth hormone signaling.

Side effects

Astragalus Extract Concentrate is generally considered safe, with a low incidence of adverse effects in clinical studies. Common side effects, occurring in more than 5% of users, include mild gastrointestinal discomfort. Uncommon side effects, affecting 1-5% of users, may include rare allergic reactions. Severe adverse events are not consistently reported. Potential drug interactions exist, particularly with immunosuppressants and chemotherapy agents, necessitating caution. Due to limited data, caution is advised in individuals with autoimmune diseases or those undergoing immunosuppressive therapy. Safety during pregnancy and lactation is not well established. It is crucial to consult with a healthcare professional before using Astragalus Extract Concentrate, especially if you have pre-existing conditions or are taking other medications.

Dosage

Dosage recommendations for Astragalus Extract Concentrate vary depending on the formulation and intended use. Clinical studies typically use standardized extracts equivalent to several grams of root per day. Optimal dosage ranges are not firmly established, and meta-analyses include diverse dosing regimens. While a maximum safe dose is not clearly defined, traditional use suggests good tolerance. It is often administered alongside chemotherapy or as part of multi-herbal formulas. Oral capsules, tablets, decoctions, and injections have been studied. Bioavailability can be enhanced by certain extraction methods, and co-administration with food may affect absorption. Consultation with a healthcare provider is recommended to determine the appropriate dosage.

FAQs

Is Astragalus Extract Concentrate safe to take with chemotherapy?

Evidence suggests it may enhance chemotherapy efficacy and is generally safe, but consultation with oncologists is essential due to possible interactions.

How long before benefits are seen?

Clinical improvements in tumor response or cardiac markers are typically observed within weeks to months of combined therapy.

Can it be used for fatigue?

Preliminary evidence supports use in cancer-related fatigue, but more conclusive data are awaited.

Does it interact with other medications?

Potential interactions exist; medical supervision is recommended to avoid adverse effects.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC6700271/ – This meta-analysis of 8 RCTs found that Astragalus combined with chemotherapy improved tumor response rate in cancer patients compared to chemotherapy alone. The effect was consistent across different administration routes, suggesting a potential benefit of Astragalus as an adjunct therapy.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7652609/ – A systematic review of 28 RCTs and 16 animal studies showed that Astragalus membranaceus significantly reduced myocardial enzymes and improved clinical efficiency in patients with viral myocarditis. The study suggests that Astragalus may have a protective effect on the heart in the context of viral infections.
https://www.mdpi.com/2072-6643/17/3/416 – This study demonstrated that a novel Astragalus-based extract promoted bone growth through IGF-1 upregulation. These findings suggest potential anabolic effects of Astragalus on bone tissue.
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.00795/full – This preclinical meta-analysis showed that astragaloside IV reduced myocardial infarct size and improved cardiac function in animal models. The results indicate that astragaloside IV, a key component of Astragalus, may have cardioprotective properties.
https://journals.lww.com/md-journal/fulltext/2022/01210/astragalus_membranaceus__huang_qi__for.53.aspx – This article discusses the use of Astragalus membranaceus for cancer-related fatigue (CRF). Preliminary data suggests improvement in fatigue severity, though comprehensive results are pending, indicating a potential benefit in managing CRF.