Astragalus Concentrated Extract
Also known as: Astragalus membranaceus, Astragalus mongholicus, Huang Qi, Milkvetch Root
Overview
Astragalus, scientifically known as *Astragalus membranaceus*, is a perennial plant native to northern China and Mongolia, where its root has been used medicinally for centuries. It is also known as Huang Qi or Milkvetch Root. As an adaptogenic herb, astragalus is traditionally used to support immune function, cardiovascular health, and overall vitality. The root contains bioactive compounds such as astragalosides and polysaccharides, which are believed to be responsible for its therapeutic effects. While research is ongoing, current evidence suggests potential benefits in specific conditions like viral myocarditis and cancer-related fatigue. Astragalus is available in various forms, including dried root, capsules, tablets, and liquid extracts. Standardized extracts are often preferred to ensure consistent levels of active compounds. Its use is rooted in traditional Chinese medicine, where it is considered a tonic for strengthening the body's defenses.
Benefits
Astragalus has demonstrated benefits in specific clinical conditions. A systematic review of 28 RCTs showed that Astragalus significantly reduced serum myocardial enzymes and improved clinical treatment efficiency in patients with viral myocarditis (*P* < 0.05). Another meta-analysis of 8 RCTs found that Astragalus supplementation reduced cancer-related fatigue (SMD = −1.63, 95% CI [−1.90, −1.36], *P* < 0.00001) and improved quality of life. Preclinical and clinical data also support anti-inflammatory, antioxidant, and cardioprotective effects. The strongest evidence supports its use in patients with viral myocarditis or cancer-related fatigue. Benefits are typically observed within 4–12 weeks of supplementation. While promising, more research is needed to confirm these benefits in broader populations.
How it works
Astragalus exerts its effects through multiple biological pathways. It exhibits anti-inflammatory, antioxidant, antiapoptotic, antifibrotic, and antiviral properties. Primarily, it interacts with the cardiovascular and immune systems. On a molecular level, astragalus modulates cytokine production, reduces oxidative stress, and may influence viral receptor expression. The astragalosides and polysaccharides present in astragalus are likely the main bioactive components. However, limited data exists regarding the absorption and bioavailability of these compounds in humans. Further research is needed to fully elucidate the pharmacokinetic properties and mechanisms of action of astragalus.
Side effects
Astragalus is generally well-tolerated in clinical studies. Common side effects are not frequently reported, but uncommon side effects may include mild gastrointestinal upset and allergic reactions in sensitive individuals. Rare side effects are not well-documented, but there is a potential for immune stimulation in susceptible individuals. Caution is advised when using astragalus with immunosuppressants and anticoagulants due to potential drug interactions. It is contraindicated in individuals with autoimmune conditions or during acute infections unless under medical supervision. Limited data exists regarding its safety during pregnancy, lactation, and in children, so use with caution is recommended. It is important to consult with a healthcare professional before taking astragalus, especially if you have any underlying health conditions or are taking medications.
Dosage
The minimum effective dose of astragalus is not well established, but most clinical studies use 1–4 g/day of dried root or an equivalent extract. Optimal dosage ranges are typically 2–4 g/day of dried root or 100–500 mg/day of a concentrated extract, standardized to astragalosides or polysaccharides. While the maximum safe dose is not well-defined, doses up to 8 g/day have been used in some studies without significant adverse effects. It is typically taken in divided doses with meals to enhance absorption. Standardized extracts are preferred for consistency. No specific cofactors are required for its absorption or activity.
FAQs
Is astragalus safe?
Astragalus is generally safe for most adults. However, individuals with autoimmune diseases or those taking immunosuppressants should avoid it unless under medical supervision.
When and how should I take astragalus?
Take astragalus with meals to enhance absorption. Effects may be seen within 4–12 weeks of consistent use.
What are the expected benefits of astragalus?
Most evidence supports benefits in specific conditions like viral myocarditis and cancer-related fatigue. General immune or energy benefits are less clearly established.
Is astragalus a cure-all?
No, astragalus is not a cure-all. Its benefits are condition-specific and not universally applicable. It should be used as a complementary therapy.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7652609/ – This systematic review and meta-analysis of 28 RCTs (n=2522) found that Astragalus significantly reduced cardiac biomarkers and improved clinical outcomes in patients with viral myocarditis compared to control (*P* < 0.05). The study concluded that Astragalus could be a beneficial adjunctive therapy for viral myocarditis, with no increase in adverse events reported.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12041688/ – This meta-analysis of 8 RCTs focused on cancer patients with fatigue and found that Astragalus significantly reduced fatigue (SMD = −1.63, 95% CI [−1.90, −1.36], *P* < 0.00001) and improved quality of life (RR = 1.55, 95% CI). The study suggests that Astragalus supplementation may be an effective strategy for managing cancer-related fatigue.
- https://www.mdpi.com/2072-6643/17/3/416 – This review explores the potential benefits of Astragalus in kidney diseases, highlighting its anti-inflammatory and antioxidant properties. It suggests that Astragalus may protect against kidney damage by reducing oxidative stress and inflammation, but further clinical trials are needed to confirm these effects in humans.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1043236/full – This systematic review and meta-analysis of animal studies found that Astragalus polysaccharide demonstrated significant anti-inflammatory and antioxidant effects in animal models of ulcerative colitis. The study suggests that Astragalus polysaccharide may have therapeutic potential for ulcerative colitis, but human data are needed to confirm these findings.
- https://www.mskcc.org/cancer-care/integrative-medicine/herbs/astragalus – This resource from Memorial Sloan Kettering Cancer Center provides an overview of Astragalus, including its uses, potential benefits, and safety considerations. It notes that Astragalus has been used traditionally to boost the immune system and may have anti-inflammatory and antioxidant effects, but more research is needed to confirm these benefits.
Supplements Containing Astragalus Concentrated Extract
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