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Astragalus Complanatus Extract

Also known as: Astragalus, Huang Qi, Astragalus membranaceus, Astragalus complanatus

Overview

Astragalus complanatus extract is derived from the roots of the Astragalus genus plants, a traditional Chinese medicine (TCM) herb. While closely related to and often studied alongside Astragalus membranaceus, it is a distinct species. This extract is primarily used for its immune-modulating, anti-inflammatory, and adaptogenic properties. Its main applications include supporting immune function, improving outcomes in chronic kidney disease (CKD), reducing cancer-related fatigue, and potentially aiding in cardiovascular, respiratory, and neurological injury recovery. The extract contains various bioactive compounds such as polysaccharides, saponins, and flavonoids. Research on Astragalus complanatus is emerging, with more extensive clinical evidence available for Astragalus membranaceus, often used interchangeably or as a reference point due to their similar properties and traditional uses. The quality of evidence includes systematic reviews and meta-analyses, with some high-quality randomized controlled trials.

Benefits

Astragalus complanatus extract, and closely related Astragalus species, offer several evidence-based benefits. A meta-analysis of 9 randomized controlled trials demonstrated that Astragalus-containing Chinese herbal medicine, when combined with Western medicine, significantly reduced serum creatinine levels in patients with chronic kidney disease (SMD = 0.64, 95% CI: 0.27–1.01, p < 0.001), indicating improved renal function. For cancer-related fatigue, a systematic review and meta-analysis of 8 RCTs found that Astragalus membranaceus significantly reduced fatigue (SMD = −1.63, 95% CI [−1.90, −1.36], p < 0.00001) and improved quality of life, though heterogeneity was noted. In neurological recovery, a meta-analysis of 16 animal studies showed that Astragalus membranaceus extract improved functional recovery after spinal cord injury (mean difference = 3.68, 95% CI = 2.74–4.62), suggesting neuroprotective potential, though human trials are needed. Additionally, Astragalus injection has shown cardiopulmonary benefits, reducing mortality in conditions like heart failure and respiratory failure and improving 6-minute walk test distances. These benefits are particularly relevant for patients with CKD, cancer-related fatigue, and potentially those recovering from neurological injuries or with cardiopulmonary conditions. Effect sizes are moderate to large, indicating clinically significant improvements.

How it works

Astragalus complanatus exerts its effects through multiple biological pathways, primarily involving immunomodulation, anti-inflammatory actions, and antioxidant activity. Its active compounds, including polysaccharides and saponins, are known to influence cytokine production and the NF-κB pathway, which are central to inflammatory responses. The extract also enhances mitochondrial function and promotes tissue repair. In the context of renal function, it helps by reducing oxidative stress and inflammation. For fatigue, it modulates immune responses, contributing to energy regulation. In neurological recovery, it appears to promote neural regeneration and functional recovery post-injury. While oral bioavailability of all active compounds varies, some polysaccharides are partially absorbed and may exert effects via the gut-immune axis, contributing to its systemic benefits.

Side effects

Astragalus complanatus extract is generally well tolerated, with clinical trials reporting no serious adverse events. Mild gastrointestinal discomfort is the most commonly reported side effect, occurring in some individuals. Uncommon side effects (1-5%) include rare allergic reactions. No significant rare adverse events (<1%) have been documented in high-quality studies. However, potential drug interactions exist. Due to its immune-modulating properties, caution is advised when used concurrently with immunosuppressants, as it may theoretically reduce their efficacy. It may also have mild antiplatelet effects, warranting caution with anticoagulants. Contraindications include pregnancy and breastfeeding due to limited safety data, and individuals on immunosuppressive therapy should consult a healthcare provider before use. Data on pediatric and elderly populations are limited, with most studies conducted in adults.

Dosage

The optimal dosage of Astragalus complanatus extract varies depending on the specific extract and its standardization. Clinical trials often use doses equivalent to 30-60 grams of raw Astragalus root per day. For conditions like cancer-related fatigue and chronic kidney disease, doses equivalent to 30-60 grams daily of Astragalus membranaceus root extract have shown efficacy. The maximum safe dose is not definitively established, but doses up to 90 grams per day, divided throughout the day, have been used in some studies without serious adverse effects. Consistent daily dosing is recommended, with benefits typically observed after several weeks of continuous use. Extracts standardized to polysaccharide or saponin content are preferred for consistency in dosing. While no specific cofactors are required, general nutritional support is advisable. Co-administration with food may improve gastrointestinal tolerance.

FAQs

Is Astragalus complanatus extract safe for long-term use?

Current evidence suggests good safety for use up to several months. However, long-term safety data beyond this period are limited, and ongoing monitoring is advisable.

Can it be used alongside conventional therapies?

Yes, it is often used as an adjunctive therapy, particularly in chronic kidney disease and cancer-related fatigue. However, monitoring for potential interactions with immunosuppressants and anticoagulants is recommended.

How soon can benefits be expected?

Improvements in fatigue and renal function may become apparent within several weeks of consistent use. Neurological benefits observed in animal models have been noted within 1-2 weeks.

Are benefits proven in humans or only animals?

Clinical evidence supports benefits in humans for conditions like cancer-related fatigue and improved renal function. Neurological benefits, while promising, are primarily supported by animal studies and require further human trials.

Research Sources

  • https://pmc.ncbi.nlm.nih.gov/articles/PMC11885490/ – This systematic review and meta-analysis of 9 RCTs found that Astragalus-containing Chinese herbal medicine combined with Western medicine significantly reduced serum creatinine levels in CKD patients, indicating improved renal function. Despite high heterogeneity, the findings suggest a beneficial role for Astragalus in kidney health.
  • https://journals.sagepub.com/doi/10.1177/15347354241313344 – This systematic review and meta-analysis of 8 RCTs concluded that Astragalus membranaceus significantly reduced cancer-related fatigue and improved quality of life in cancer patients. While heterogeneity was noted, the overall evidence supports its use as an adjunctive therapy for fatigue.
  • https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1637608/full – This systematic review and meta-analysis of 16 animal studies demonstrated that Astragalus membranaceus extract improved functional recovery after spinal cord injury in rats. The findings suggest neuroprotective potential, though further human research is needed to confirm these effects.
  • https://onlinelibrary.wiley.com/doi/10.1155/2020/2803478 – This review discusses the cardiopulmonary benefits of Astragalus injection, noting its potential to reduce mortality in diseases characterized by 'Zong Qi depression,' such as heart failure and respiratory failure, and improve functional capacity as measured by the 6-minute walk test.
  • https://pubmed.ncbi.nlm.nih.gov/40823287/ – This PubMed entry corresponds to one of the studies included in the neurological recovery meta-analysis, reinforcing the evidence for Astragalus membranaceus's potential in improving functional recovery after spinal cord injury in animal models.

Supplements Containing Astragalus Complanatus Extract

Golden Lock Teapills by Plum Flower
74

Golden Lock Teapills

Plum Flower

Score: 74/100