Angelicae Sinensis Extract
Also known as: Dang Gui, Dong Quai, Angelica sinensis
Overview
*Angelica sinensis* (Oliv.) Diels, commonly known as Dang Gui or Dong Quai, is a plant native to China valued for its medicinal properties, particularly its roots. These roots are rich in various bioactive compounds such as polysaccharides, ligustilide, and ferulic acid, leading to its widespread use in Traditional Chinese Medicine (TCM). It is primarily known for its role in tonifying blood, relieving menstrual pain, and treating various female health issues. Additionally, emerging research indicates potential applications in serious conditions like breast cancer and idiopathic pulmonary fibrosis. The research maturity level surrounding *Angelica sinensis* is moderate, with evidence ranging from high-quality systematic reviews to studies with methodological limitations, highlighting the need for further investigation into its pharmacological effects.
Benefits
The main benefits of *Angelica sinensis* include its notable anti-inflammatory and antioxidant effects, which are significant for reducing oxidative stress and inflammation. It may also support cardiovascular health, potentially improving vascular function and lowering the risk of atherosclerosis. In specific populations, it shows benefits for women experiencing menstrual disorders, and patients recovering from ischemic stroke. Research has suggested that *A. sinensis* may not only counteract the risks associated with breast cancer but also serve a therapeutic role. Additional studies are needed to determine effect sizes and clinical significance across its applications, as the documented benefits vary.
How it works
*Angelica sinensis* operates primarily through its anti-inflammatory and antioxidant properties, modulating several biological pathways. Its bioactive compounds are thought to interact with estrogen receptors weakly while influencing various inflammatory signaling routes, which can impact the cardiovascular, nervous, and possibly endocrine systems. However, detailed studies on its absorption and bioavailability are limited, and individual preparation methods may influence its efficacy.
Side effects
Generally considered safe when used appropriately, *Angelica sinensis* may cause mild gastrointestinal distress or allergic reactions in some users. Rarely, it could lead to serious adverse effects, such as bleeding risks associated with antiplatelet properties, particularly for those on blood thinners. While uncommon side effects aren't well-documented, caution is strongly advised for pregnant or breastfeeding women due to insufficient safety data. It’s also recommended that individuals with bleeding disorders or those taking anticoagulants discuss usage with their healthcare providers before consuming this herbal supplement.
Dosage
The optimal dosage of *Angelica sinensis* is not firmly established and varies widely depending on the condition being treated. Traditionally, doses range from 1 to 10 grams per day, often prepared as a decoction or in capsules. Safety limits for higher dosages are not well-defined, so caution is warranted beyond traditional uses. Timing and form may also affect absorption and efficacy, emphasizing the need for individualized dosing based on specific health needs.
FAQs
Is *Angelica sinensis* safe to take with medications?
Consult a healthcare provider before use, especially if you are taking anticoagulants or other medications, due to potential interactions.
How long does it take to see effects from *Angelica sinensis*?
Effects vary depending on the individual and condition, but it may take several weeks to notice significant improvements.
Can I use *Angelica sinensis* as a substitute for prescribed medications?
No, *Angelica sinensis* should not replace medical treatment; always use under the guidance of a healthcare provider.
What are common misconceptions about *Angelica sinensis*?
Some believe it is universally safe; however, it can interact with certain medications and is not advised for use during pregnancy.
What is the best way to take *Angelica sinensis*?
Typically as a decoction or in capsule form, follow traditional guidelines, or consult a healthcare provider for personalized advice.
Research Sources
- https://www.xiahepublishing.com/2835-6357/FIM-2023-00002 – This systematic review discusses the relationship between *Angelica sinensis* and breast cancer. It assesses various studies and concludes that *A. sinensis* does not increase breast cancer risk and may provide therapeutic benefits, although variability in study designs is noted.
- https://pubmed.ncbi.nlm.nih.gov/27211015/ – This meta-analysis of 17 randomized controlled trials investigates the effects of *Angelica sinensis* combined with *Radix Astragali* on idiopathic pulmonary fibrosis, finding significant improvements in pulmonary function and exercise tolerance, emphasizing the high quality of included studies.
- https://pubmed.ncbi.nlm.nih.gov/32425767/ – This systematic review evaluates the efficacy of *Angelica sinensis* on neurological function post-ischemic stroke, indicating potential benefits but highlighting the lack of human trial data, suggesting further investigation is necessary.
