Amylase Ii
Also known as: Amylase inhibitors, Alpha-amylase inhibitors, Carbohydrate blockers, White kidney bean extract, Amylase II, Phaseolus vulgaris extract
Overview
Phaseolus vulgaris extract, commonly known as white kidney bean extract, contains amylase inhibitors that interfere with the digestion of carbohydrates. These inhibitors block the alpha-amylase enzyme, which is responsible for breaking down complex carbohydrates into simple sugars. By inhibiting this enzyme, the extract aims to reduce the amount of glucose absorbed into the bloodstream, potentially leading to weight loss and improved blood sugar control. It is primarily used as a dietary supplement for weight management. The extract is available in various forms, including capsules and tablets, and is derived from the common bean, Phaseolus vulgaris. Research on its efficacy is mixed, with some studies showing statistically significant weight loss, while others report less consistent results. The quality of available evidence varies, with meta-analyses and clinical trials providing insights into its potential benefits and limitations.
Benefits
Phaseolus vulgaris extract has been studied for its potential benefits in weight management. Some studies suggest statistically significant reductions in body weight and fat mass. A meta-analysis reported an average weight loss of approximately 1.08 kg with Phaseolus vulgaris supplementation. The extract may also reduce glucose absorption and decrease carbohydrate intake. It may be particularly beneficial for individuals seeking to manage their weight, especially those with diets high in carbohydrates. However, the clinical significance of the weight loss achieved is often debated, as it may not always meet the threshold for clinically significant weight loss (5% reduction in body weight). Benefits are typically observed over several weeks to months of supplementation.
How it works
Phaseolus vulgaris extract works by inhibiting the alpha-amylase enzyme in the digestive system. This enzyme is responsible for breaking down complex carbohydrates into simple sugars, which are then absorbed into the bloodstream. By blocking alpha-amylase, the extract reduces the digestion and absorption of carbohydrates, leading to a decrease in the amount of glucose entering the bloodstream. This mechanism can potentially aid in weight loss by reducing the caloric impact of carbohydrate-rich foods. The extract primarily affects the gastrointestinal system and interacts directly with the alpha-amylase enzyme.
Side effects
Phaseolus vulgaris extract is generally considered safe, but it can cause some side effects, primarily gastrointestinal symptoms. Common side effects include flatulence, soft stools, and constipation. Some individuals may also experience headaches. Drug interactions are possible, particularly with diabetes medications, due to the extract's effects on glucose absorption. Caution is advised for individuals with diabetes or those taking medications that affect blood sugar levels, as the extract may alter blood glucose control. Pregnant or breastfeeding women should consult healthcare providers before using Phaseolus vulgaris extract. While rare side effects are not well-documented, it is essential to monitor for any adverse reactions and discontinue use if they occur.
Dosage
The minimum effective dose of Phaseolus vulgaris extract is not well-established, but typical dosages range from 445 mg to 1500 mg per day. Doses vary widely across studies, and there is no clear optimal range identified. It is typically taken before meals to maximize its carbohydrate-blocking effects. The extract is often available as capsules or tablets. Because it is designed to act locally in the gut, absorption factors are less relevant. There are no identified required cofactors. The maximum safe dose has not been definitively established, so it is important to adhere to recommended dosages and monitor for any adverse effects.
FAQs
How should I take Phaseolus vulgaris extract?
It is best taken before meals to inhibit carbohydrate digestion. Follow the dosage instructions on the product label or as advised by a healthcare professional.
Is Phaseolus vulgaris extract safe?
Generally safe, but may cause gastrointestinal side effects like flatulence. Individuals with diabetes should use caution due to potential interactions with diabetes medications.
What results can I expect from taking Phaseolus vulgaris extract?
Weight loss may be modest and variable among individuals. It is most effective when combined with a balanced diet and regular exercise.
Are there any drug interactions?
Yes, it may interact with diabetes medications due to its effects on glucose absorption. Consult with a healthcare provider if you are taking any medications.
What are the common misconceptions about Phaseolus vulgaris extract?
Some users may overestimate its efficacy or underestimate potential side effects. It is not a magic bullet for weight loss and should be used as part of a comprehensive approach.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/29677119/ – The systematic review and meta-analysis by Udani et al. (2018) investigated the effects of Phaseolus vulgaris supplementation on body weight and body fat. The study found statistically significant effects, with an average weight loss of −1.08 kg, suggesting potential benefits for weight management.
- https://www.semanticscholar.org/paper/Systematic-Review-and-Meta-Analysis-of-a-Inhibitor-Udani-Tan/ca64570540f29302b694f61a970e10944db10e2a – This systematic review and meta-analysis examined the impact of alpha-amylase inhibitors on body weight and composition. The results indicated a statistically significant reduction in body fat, supporting the use of these inhibitors as a weight-loss aid.
- https://onlinelibrary.wiley.com/doi/10.1155/2016/8541839 – The systematic review by Onakpoya et al. (2011) assessed the efficacy of Phaseolus vulgaris extract for weight loss. The review noted a statistically significant reduction in body fat but highlighted considerable heterogeneity among studies, questioning the clinical significance of the weight loss achieved.
- https://academic.oup.com/bjs/article-abstract/103/4/328/6136637 – This abstract discusses a study on the effects of amylase inhibitors. While the abstract itself doesn't provide specific results, it indicates research into the potential of these inhibitors to impact carbohydrate digestion and absorption.
- https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/efficacy-of-phaseolus-vulgaris-as-a-weightloss-supplement-a-systematic-review-and-metaanalysis-of-randomised-clinical-trials/486488712F3A8CE3A25D97533A21DDEB – This systematic review and meta-analysis of randomized clinical trials evaluated the efficacy of Phaseolus vulgaris as a weight-loss supplement. The study provides a comprehensive overview of the available evidence, assessing the impact of the supplement on weight management.
