Ampelopsis Grossedentata Extract
Also known as: Vine tea, Mustang grape, Dihydromyricetin, Ampelopsis grossedentata
Overview
*Ampelopsis grossedentata* is an herbal plant predominantly used in traditional medicine, known for its leaves commonly brewed as vine tea. Rich in antioxidants, particularly dihydromyricetin (DHM), the extract exhibits notable anti-inflammatory properties. Emerging research indicates its potential health benefits, including reducing inflammation and oxidative stress, alongside applications in food preservation. The extract is commonly found in dietary supplements and beverages, although a comprehensive understanding of its benefits and safety profile necessitates further scientific exploration.
Benefits
1. **Anti-inflammatory Effects**: Studies indicate that *Ampelopsis grossedentata* extract inhibits the production of pro-inflammatory cytokines, which may significantly benefit individuals with chronic inflammatory conditions. 2. **Antioxidant Activity**: The extract demonstrates substantial antioxidant properties, helping protect against oxidative stress in food products and potentially in human health. 3. **Poultry Performance**: Research suggests that the extract may improve egg quality and laying performance in poultry when used as a dietary supplement. 4. **Population Specific**: Beneficial for individuals experiencing oxidative stress-related conditions, although detailed population studies are limited. While effect sizes vary, notable reductions in inflammatory markers have been consistently observed across several studies.
How it works
The mechanism of action for *Ampelopsis grossedentata* involves the inhibition of the NF-κB pathway, a crucial mediator of inflammation, which leads to a reduction in the expression of pro-inflammatory genes such as COX-2 and NLRP3. This extract interacts with immune cells, particularly peripheral blood mononuclear cells, modulating inflammatory responses and promoting antioxidant defenses. Although specific absorption and bioavailability data in humans remain insufficient, the presence of dihydromyricetin is essential in mediating these biological effects.
Side effects
While the available data suggest that *Ampelopsis grossedentata* is generally safe within dietary limits, comprehensive human safety studies are lacking. Currently, documented side effects are scarce, and there is no established evidence for common, uncommon, or rare adverse effects. The absence of significant drug interactions is noted; however, individuals, especially pregnant or breastfeeding women, should seek advice from healthcare providers prior to introduction of the supplement due to the lack of specific contraindications and extensive safety data.
Dosage
Optimal dosage ranges for *Ampelopsis grossedentata* extract are not well-defined; however, studies have employed concentrations ranging from 10 to 100 μg/mL in in vitro settings. A minimum effective dose has yet to be established, and there is no defined maximum safe dose. As the extract is commonly used in dietary supplements, it’s crucial to monitor individual responses, with a physician's consultation highly recommended for those considering use in high doses or specific conditions.
FAQs
Is *Ampelopsis grossedentata* safe to use?
Generally, yes, but comprehensive safety data are lacking, so consulting with a healthcare provider is advised.
Can I take it without consulting a doctor?
It’s best to consult a healthcare provider before starting any new supplement, especially if pregnant or breastfeeding.
What benefits can I expect?
Potential benefits include reduced inflammation and oxidative stress, although individual results may vary.
Does it interact with medications?
There is currently no substantial evidence of potential drug interactions.
Research Sources
- https://www.mdpi.com/1422-0067/25/1/416 – This study examines the effects of *Ampelopsis grossedentata* on human immune cells, demonstrating its capacity to inhibit reactive oxygen species (ROS) production and reduce pro-inflammatory cytokine levels, indicating significant anti-inflammatory potential.
- https://onlinelibrary.wiley.com/doi/abs/10.1002/fsn3.1013 – The assessment of antioxidant activity of vine tea extract in food products highlights its ability to enhance texture and reduce oxidation in pork patties, suggesting practical applications in food preservation.
- https://pubmed.ncbi.nlm.nih.gov/35015154/ – This research focuses on dietary supplementation of *Ampelopsis grossedentata* in laying hens, reporting improvements in laying performance and egg quality, indicating agricultural benefits.
- https://www.mdpi.com/2076-3921/8/8/295 – This article provides an overview of the antioxidant properties of *Ampelopsis grossedentata*, supporting its traditional use in antioxidant and anti-inflammatory applications.
