Albion Magnesium Bisglycinate
Also known as: Magnesium Glycinate, Magnesium Bisglycinate, Magnesium Bisglycinate Chelate
Overview
Magnesium Bisglycinate Chelate is a chelated form of magnesium, bound to the amino acid glycine to enhance its bioavailability and gastrointestinal tolerance. While it is not naturally occurring, this form is synthesized for improved absorption compared to other magnesium supplements. It is primarily used to support magnesium intake, especially in individuals suffering from magnesium deficiency or who experience gastrointestinal side effects from other forms. Magnesium is vital for various biological processes, and its supplementation may enhance overall health through various mechanisms. The body of research behind Magnesium Bisglycinate Chelate indicates moderate maturity, featuring a range of clinical trials and meta-analyses supporting its efficacy and safety as a dietary supplement.
Benefits
Evidence-based benefits of Magnesium Bisglycinate Chelate include a significant reduction in depression scores, with a systematic review reporting a standard mean difference (SMD) of -0.919 (p = 0.001). It has been shown to alleviate menstrual pain significantly, with a study noting a reduction or elimination of abdominal pain in women with dysmenorrhea when 400 mg was consumed daily. Additionally, Magnesium Bisglycinate may contribute to improved glycemic control, lipid profiles, and blood pressure in type 2 diabetes patients, providing population-specific benefits especially for women with dysmenorrhea and individuals experiencing depressive symptoms. The effect sizes reported indicate clinically meaningful outcomes, particularly regarding mental health.
How it works
Magnesium acts on various biological pathways, including neuronal function, muscle contraction, and energy metabolism. It modulates key systems such as the cardiovascular and nervous systems by affecting neurotransmitter release and vascular function. The chelation with glycine enhances absorption, allowing for increased availability of magnesium in the body and reduced interactions with dietary components, which could otherwise hinder its bioavailability. Overall, the mechanisms involve a variety of ion channels and enzymatic activities critical for numerous physiological processes.
Side effects
Magnesium Bisglycinate Chelate is generally considered safe, especially compared to other magnesium supplements. Common side effects occur in less than 5% of users and could include mild gastrointestinal discomfort, which is substantially less than what is reported with magnesium oxide or citrate. Some less common side effects (1-5%) may include diarrhea, nausea, and stomach cramps. Rare side effects (<1%) have not been reported. It is important to be cautious with drug interactions, especially concerning antibiotics and anticoagulants. Individuals with severe kidney dysfunction should refrain from use unless under medical supervision. Pregnant or breastfeeding women should consult healthcare providers prior to use due to potential risks.
Dosage
For magnesium supplementation, the minimum effective dose starts at approximately 200-300 mg per day, while general health recommends about 400 mg daily. Those addressing specific issues, like depression or menstrual pain, may benefit from tailored dosages depending on individual responses. The Tolerable Upper Intake Level (UL) from supplements is generally set at 350 mg per day. Magnesium Bisglycinate Chelate can be taken at any time during the day, though it is advised to combine it with meals to mitigate gastrointestinal effects. Its chelated form provides enhanced absorption capabilities over standard forms, leading to more efficient utilization.
FAQs
Is Magnesium Bisglycinate safe to take?
Yes, it is generally well-tolerated, but those with kidney issues should consult a physician.
When should I take Magnesium Bisglycinate?
It can be taken any time of day, preferably with meals to minimize digestive discomfort.
What benefits can I expect from taking this supplement?
Users may experience improved mood, reduced menstrual pain, and better management of glycemic control over time.
Are all forms of magnesium the same?
No, magnesium bisglycinate is specifically known for its higher bioavailability and reduced gastrointestinal side effects.
Research Sources
- https://acct14095.app.netsuite.com/core/media/media.nl?id=1173&c=ACCT14095&h=94fe9643594e12b65089&_xt=.pdf – This source provides insights on the high bioavailability and gastrointestinal tolerance of Magnesium Bisglycinate Chelate compared to standard magnesium salts, appreciably supporting its preference for supplementation.
- https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1333261/full – A systematic review that shows magnesium supplementation significantly reduces depression scores, pointing to its potential mental health benefits.
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.1020327/full – This meta-analysis examines magnesium's role in improving diabetes-related health metrics, suggesting critical health implications for various populations.
- https://balchem.com/hnh/products/mn/mg/magnesium-bisglycinate-chelate/ – This resource discusses the unique formulation of Magnesium Bisglycinate Chelate, detailing its absorption characteristics and ideal use cases for consumers.
- https://pubmed.ncbi.nlm.nih.gov/38213402/ – A clinical study demonstrating the superior absorption of Magnesium Bisglycinate Chelate over magnesium chloride, confirming its increased efficacy as a supplement.
Supplements Containing Albion Magnesium Bisglycinate
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