Aged Garlic Bulb Extract
Also known as: Aged Garlic Bulb Extract, AGE, Aged Garlic Extract, *Allium sativum*
Overview
Aged Garlic Bulb Extract (AGE) is derived from *Allium sativum*, garlic that undergoes a natural aging process to enhance its bioactive compounds. This supplement is primarily recognized for its cardiovascular benefits, anti-inflammatory effects, and immune system support. Rich in antioxidants and sulfur compounds, particularly S-allylcysteine, AGE has moderate research backing with several clinical trials indicating its potential health benefits. The aging process markedly increases the bioavailability of its active compounds, making it a popular choice among dietary supplements. Currently, it is used in various forms, primarily capsules or tablets, and is gaining attention for its favorable safety profile.
Benefits
AGE offers several evidence-based benefits: 1) Blood Pressure Reduction: A meta-analysis indicates that AGE significantly decreases systolic blood pressure (SBP) by -4.03 mmHg and diastolic blood pressure (DBP) by -1.44 mmHg, especially at doses over 1200 mg/day. 2) Inflammation Reduction: It has been shown to lower inflammatory markers like TNF-α and IL-6, particularly in obese individuals. 3) Lipid Profile Improvement: Garlic supplementation, including AGE, contributes to lowering total cholesterol and LDL-C levels. Notably, its effects are most pronounced in hypertensive patients or those with obesity, with moderate effect sizes significant for clinical relevance. Benefits are usually observed within weeks to months of consistent supplementation.
How it works
AGE works primarily through its antioxidant and anti-inflammatory properties. It influences various biological pathways by modulating immune cell function and cytokine production. S-allylcysteine, a main compound in AGE, interacts with multiple cellular targets to reduce inflammation and oxidative stress. Additionally, AGE's beneficial effects are facilitated by its enhanced bioavailability through the aging process, allowing for greater absorption and efficacy within the cardiovascular, immune, and metabolic systems.
Side effects
AGE is generally considered safe for consumption when used as directed. Common side effects that occur in over 5% of users include gastrointestinal discomfort, such as bloating or gas. Uncommon side effects (1-5%) may involve allergic reactions. Severe allergic reactions are rare (<1%). Caution is advised for individuals taking anticoagulants, as AGE may interact with these medications, enhancing the risk of bleeding. Pregnant or breastfeeding women should consult a healthcare provider due to limited safety data in these populations. Special care should also be taken for individuals with bleeding disorders due to potential increased bleeding risk.
Dosage
The minimum effective dose of AGE is approximately 600 mg/day, with optimal dosages around 1200 mg/day for significant blood pressure effects. While not well established, doses up to 3600 mg/day have been safely utilized in studies. Timing considerations suggest that AGE is best taken with meals to mitigate gastrointestinal side effects. The most common forms of AGE include capsules or tablets, and enhanced bioavailability is a result of the aging process. No specific cofactors are needed for absorption.
FAQs
Is Aged Garlic Bulb Extract safe to take?
AGE is generally safe for most individuals, but those on anticoagulants should use it cautiously.
When should I take Aged Garlic Bulb Extract?
It is advisable to take AGE with meals to minimize gastrointestinal discomfort.
How long does it take to see the benefits?
The benefits of AGE may typically be observed within weeks to months of consistent use.
Can Aged Garlic Bulb Extract replace treatments for cardiovascular diseases?
AGE is not a cure-all but can complement other treatments for cardiovascular health.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/39437887/ – This systematic review and meta-analysis of nine RCTs with 584 hypertensive patients found that AGE significantly reduces SBP and DBP, with more pronounced effects noted at higher doses.
- https://pubmed.ncbi.nlm.nih.gov/29576354/ – A randomized, double-blind, placebo-controlled trial with 51 adults demonstrated that AGE reduced inflammatory markers and enhanced immune cell distribution over six weeks.
- https://www.mdpi.com/2072-6643/16/11/1692 – This systematic review aggregate findings from multiple studies, indicating that garlic, including AGE, significantly improves lipid profiles and reduces inflammation, albeit with some heterogeneity among studies.
Supplements Containing Aged Garlic Bulb Extract
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