African Geranium Root Extract
Also known as: African Geranium, EPs 7630, Umckaloabo, Pelargonium, South African Geranium, Pelargonium sidoides
Overview
Pelargonium sidoides is a flowering plant native to regions of Southern Africa, including South Africa, Eswatini, and Lesotho. The root extract, known commercially as EPs 7630, is commonly utilized in phytopharmaceuticals, particularly for the treatment of acute viral respiratory tract infections, such as acute bronchitis and the common cold. It is rich in oligomeric prodelphinidins and various phytochemicals, which are believed to contribute to its therapeutic effects. Pelargonium sidoides has established itself within herbal medicine and has been the focus of numerous clinical trials and reviews, underscoring its efficacy while highlighting potential biases in studies financed by manufacturers.
Benefits
Evidence supporting Pelargonium sidoides extract (EPs 7630) suggests substantial benefits for individuals suffering from acute bronchitis, with clinical trials reporting significant reductions in Bronchitis Severity Scores and shorter recovery times compared to placebo interventions. It has also been shown to alleviate symptoms of the common cold, with a systematic review noting improvements in quality of life for patients with acute respiratory infections. In populations diagnosed with chronic obstructive pulmonary disease (COPD), the extract appears to help in reducing flare-ups and the necessity for antibiotic treatments. Benefits have been demonstrated in both adult and pediatric cohorts, typically improving within 7-10 days after commencing treatment.
How it works
The therapeutic effects of Pelargonium sidoides are thought to arise from its antiviral and immunomodulatory properties. The extract may enhance the body's immune response while mitigating inflammation within the respiratory tract. Key active components, particularly oligomeric prodelphinidins, interact with immune cells, promoting immune function and aiding in the alleviation of respiratory symptoms. While precise molecular mechanisms remain partially understood, general acknowledgement of these pathways supports the extract's efficacy as documented in scientific literature.
Side effects
Pelargonium sidoides is generally regarded as safe, supported by systematic reviews involving large participant numbers demonstrating well-tolerated profiles. Although infrequent, common side effects may include gastrointestinal issues and hypersensitivity reactions, reported in over 5% of users. Rare adverse effects (<1%) have not been documented in clinical studies. Caution should be taken when using the extract alongside immunosuppressants or anticoagulants due to potential interactions. While no explicit contraindications have been noted, dosage adjustments may be warranted for specific populations, including children, to ensure safety and efficacy.
Dosage
For adult individuals, the typical recommended dosage of Pelargonium sidoides extract is 30-60 drops (1.5-3 mL) administered three times daily for a duration of 7-10 days. Dosing for children is contingent upon age and should be guided by healthcare professionals. Although no officially established maximum safe dosage exists, the recommended dosages are generally regarded as safe and effective. For optimal therapeutic outcomes, initiating treatment within 48 hours upon onset of respiratory symptoms is advised. The extract is available in various forms, including drops and tablets, with adequate absorption reported for its therapeutic efficacy.
FAQs
Is Pelargonium sidoides safe?
Yes, it is generally safe, but caution is advised when using with certain medications like immunosuppressants and anticoagulants.
When should I start taking it?
For best results, treatment should begin early, ideally within 48 hours of symptom onset.
What benefits can I expect?
Users can expect reduced symptoms and a quicker recovery from acute respiratory infections.
What's the difference between Pelargonium sidoides and other geraniums?
Pelargonium sidoides is distinct from other geranium varieties, like rose geranium, which do not share the same therapeutic properties.
Research Sources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761473/ – This systematic review assesses the efficacy of Pelargonium sidoides extract EPs 7630 in treating acute bronchitis. The analysis of multiple randomized controlled trials highlights significant reductions in symptom severity and duration for patients compared to placebo, emphasizing the extract's role in managing respiratory infections.
- https://pubmed.ncbi.nlm.nih.gov/18581060/ – A clinical trial investigating the effects of Pelargonium sidoides on acute respiratory infections in pediatric patients indicates positive improvements in recovery and symptoms, confirming its potential as a therapeutic option in younger populations.
- https://www.ncbi.nlm.nih.gov/pubmed/20367210 – This research article explores the immunomodulatory actions of Pelargonium sidoides, detailing how its active constituents affect immune responses and inflammation in respiratory conditions, thus supporting its therapeutic claims.
