Sweet Wormwood Extract
Also known as: Sweet wormwood, Qinghao, Artemisia annua, Annual Wormwood, Chinese Wormwood, *Artemisia annua* L.
Overview
*Artemisia annua* is a herbaceous plant native to Asia, traditionally utilized in folk medicine and recognized for its potent antimalarial compound, artemisinin. The aerial parts of the plant are harvested and utilized in herbal extracts. Historically employed to treat fevers and malaria, it is now also explored for a range of applications, including antiviral, anti-inflammatory, and anticancer effects. Rich in bioactive compounds, such as artemisinin and flavonoids, the extract has gained attention in both traditional practices and modern research settings. Despite extensive studies demonstrating efficacy in malaria treatment and potential benefits for other conditions, further human trials are needed to substantiate its various uses and safety profile.
Benefits
Numerous evidence-based benefits are associated with *Artemisia annua* extract: - **Antimalarial Activity**: Artemisinin is highly effective against malaria, with studies showing significant reductions in parasite load and symptoms. - **Antiviral Effects**: Some extracts have demonstrated the ability to inhibit the replication of pathogens like SARS-CoV-2. - **Anti-inflammatory Properties**: Extracts modulate immune responses and pathway inhibition, potentially aiding ailments like arthritis. - **Anticancer Efficacy**: Evidence suggests benefits against various tumors and cancer types, affecting growth and metastasis. These findings are particularly relevant for individuals with predispositions to malaria, inflammatory disorders, or certain cancers.
How it works
The primary mechanism of action for *Artemisia annua* revolves around its bioactive components. Artemisinin generates reactive oxygen species that damage the membranes of malaria parasites. Additionally, extracts may inhibit viral replication by interfering with cellular processes, while the anti-inflammatory properties result from the modulation of immune pathways, including regulation of cytokine release and inhibition of enzymes involved in inflammation.
Side effects
Overall, *Artemisia annua* is considered safe, with historical use spanning over 2,000 years. Common side effects (>5%) include gastrointestinal disturbances such as nausea and vomiting. Uncommon effects (1-5%) encompass allergic reactions and skin rashes. Rare adverse effects (<1%) may involve hematological issues and neurological symptoms, especially at high doses. Caution is advised when used with anticoagulants or anticonvulsants, and it is contraindicated in pregnancy and breastfeeding due to insufficient safety data in these populations. Dosage adjustments may be necessary for children and the elderly due to potential variances in metabolism.
Dosage
For antimalarial purposes, typical doses of artemisinin range from 500 to 1000 mg per day. The effective dose can vary based on the condition; for example, a study indicated 100 mg/kg body weight for testicular dysfunction in rats. Safety thresholds suggest a maximum of 2000 mg per day for short-term uses, with prolonged usage requiring monitoring for side effects. Timing of dosage should align with the specific health challenges being addressed, particularly for acute conditions.
FAQs
Is *Artemisia annua* safe to use?
Generally safe for most individuals, but should be used under medical supervision, especially when combined with medications or in specific populations like pregnant women.
How should *Artemisia annua* be taken?
The intake method and timing depend on the condition; acute conditions like malaria require immediate high doses, while chronic conditions may necessitate prolonged treatment.
What benefits can I expect?
Expect rapid parasite load reductions in malaria treatment; anti-inflammatory and antiviral effects may take several weeks to manifest.
Is it effective only against malaria?
No, *Artemisia annua* has diverse potential applications, including against viral infections, inflammation, and various cancers.
Research Sources
- https://www.mdpi.com/2311-7524/9/6/629 – This in vitro study found that extracts of *Artemisia annua* inhibited the replication of SARS-CoV-2, showcasing its potential antiviral properties. However, more human trials are needed for conclusive evidence.
- https://pubmed.ncbi.nlm.nih.gov/37127141/ – This randomized controlled trial highlighted the use of *Artemisia annua* leaf extract in rats, demonstrating significant improvements in oxidative stress and hormonal balance, indicating potential benefits for testicular dysfunction.
- https://www.science.gov/topicpages/n/natural+medicine+research – This review summarized strong evidence for the health effects of *Artemisia annua*, highlighting its potential in managing various conditions including malaria and cancer while emphasizing the need for further research.
- https://www.mdpi.com/2304-8158/10/1/65 – This article provides an overview of the health benefits of edible Artemisia species, including potential activities against numerous diseases, reinforcing and summarizing existing literature.
- https://www.wpi.edu/news/early-research-finds-extracts-sweet-wormwood-plant-can-inhibit-covid-19-virus – The early findings indicated that extracts from sweet wormwood could inhibit the COVID-19 virus, suggesting significant antiviral potential, though further validation through human studies is needed.
Supplements Containing Sweet Wormwood Extract
GI Microb-X
Designs for Health
Wormwood Black Walnut Supreme
Gaia Herbs
Wormwood Black Walnut Supreme
Gaia Herbs
Microbiome Cleanse
Gaia Herbs
Core Para-V Blend
Energetix
Microbiome Cleanse
Gaia Herbs
ProEnt2 Plus
InterPlexus
Artemisia Trinity
Return Healthy
MicroDefense w/Oregano
Pure Encapsulations
Phytocidal
Ortho Molecular Products
MicroDefense w/Oregano
Pure Encapsulations