Phlomis Umbrosa Extract
Also known as: Phlomis umbrosa, aerial parts extract, root extract, Phlomis umbrosa extract
Overview
*Phlomis umbrosa* is a herbal plant native to East Asia, widely acknowledged for its traditional use in Chinese medicine. The roots of this plant are incorporated in various herbal formulations aimed at addressing menopausal symptoms, promoting bone health, and potentially enhancing sleep quality. Key bioactive compounds identified in *Phlomis umbrosa* include shanzhiside methyl ester, chlorogenic acid, and caffeic acid, which are believed to underpin its therapeutic properties. Research on this extract has primarily involved animal studies, presenting promising results in areas such as bone density improvement and hormonal balance, especially in menopausal populations. However, human studies remain limited and results are less definitive, requiring more rigorous examination to establish its efficacy. The safety profile of *Phlomis umbrosa* appears positive based on historical usage, yet comprehensive assessments in human subjects are scant.
Benefits
[{"benefit":"Bone Health","strength_of_evidence":"Moderate based on animal studies","population":"Rodent models; may extend to menopausal women in human studies","findings":"Animal studies indicate significant improvement in bone density markers such as IGF-1 and BMP-2 levels."},{"benefit":"Menopausal Symptoms","strength_of_evidence":"Limited human studies","population":"Menopausal women","findings":"Reported reductions in menopausal discomforts through herbal mixtures containing *Phlomis umbrosa*."},{"benefit":"Sleep Quality","strength_of_evidence":"Indirect evidence suggests potential benefits","population":"Menopausal women when combined with other herbs","findings":"Some studies imply improvements in sleep quality when *Phlomis umbrosa* is part of mixed formulations."}]
How it works
*Phlomis umbrosa* is thought to function through multiple biological mechanisms. It potentially influences the modulation of insulin-like growth factor 1 (IGF-1) and bone morphogenetic protein 2 (BMP-2), which are critical for bone remodeling. Furthermore, the extract may possess estrogenic properties that can help mitigate menopausal symptoms by balancing hormone levels. These interactions primarily engage the endocrine system, though the complete array of molecular actions remains a subject of ongoing research.
Side effects
*Phlomis umbrosa* is generally regarded as safe based on traditional usage, but scientific literature on its adverse effects is limited. There are currently no well-documented side effects reported in more than 5% of users. Nonetheless, there is a potential risk for individuals with hormonal disorders or those undergoing hormonal therapies due to the extract’s estrogen-like properties. Caution is recommended for pregnant or breastfeeding women owing to the insufficient safety data available. Additionally, there has been scant investigation into drug interactions, particularly with medications affecting hormonal levels, necessitating careful consideration in individuals on such treatments.
Dosage
The optimal dosage of *Phlomis umbrosa* extract remains undefined, with available studies largely deriving data from animal models suggesting a dosage range of 100 mg/kg to 1000 mg/kg. These ranges do not provide concrete guidance for human use, highlighting the need for further research. There are no established recommendations for the timing of supplementation, and the extract is commonly used in conjunction with other herbs, which may alter effective dosage forms like capsules or powders. Information regarding absorption factors and safe upper limits is still lacking and requires further investigation.
FAQs
Is *Phlomis umbrosa* safe for long-term use?
While generally considered safe based on traditional use, more comprehensive safety data is needed for long-term consumption.
What is the best time to take *Phlomis umbrosa*?
There is no specific guidance on the optimal timing for supplementation.
What benefits can I expect from *Phlomis umbrosa*?
Potential benefits include improved bone health and alleviation of menopausal symptoms, although these are based on limited data.
Are there any interactions I should be aware of?
Caution is advised for individuals taking hormonal therapies due to possible interactions, although specific data is still being investigated.
